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Factor V Leiden Mutation PCR

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    Factor V Leiden is a genetic mutation that increases your chances of forming abnormal blood clots. It is an inherited disorder of blood clotting. If the history of factor V Leiden thrombophilia runs deep in your family, you are at a high risk of contracting it yourself. 

    Specifics of Factor V Leiden Mutation PCR Test

    The presence of factor V and prothrombin proteins in your body is essential for proper blood clot formation. In case of a bleeding injury, these proteins begin a hemostasis process to stop the bleeding.

    Factor V Leiden gene mutation occurs when your body produces excessive blood clots that can cause a blockage in blood vessels. People suffering from this inherited disorder are at a high risk of developing a form of blood clot called deep venous thrombosis (DVT).

    These clots generally occur in the legs, although they can also occur in other body parts such as the brain, liver, eyes, and kidneys.

    Since the mutation is associated with an increased risk of miscarriage, women are 2 or 3 times more likely to have multiple miscarriages during the 2nd or 3rd trimester.

    A few studies show that it could also involve the risk of pregnancy complications, including high BP, slow fetal growth, and placental abruption.

    The Factor V Leiden mutation PCR test is advised when your doctor suspects an inherited risk factor of blood clots. The test may also be suggested if a parent or sibling has a Factor V Leiden gene mutation.

    The test results indicate whether an individual has one or two copies of Factor V Leiden mutation. If there is one copy, the individual is heterozygous, and if there are two copies, the individual is homozygous.

    However, cases with homozygous mutation are rare amongst individuals. For people affected by the heterozygous mutation, there can be a mild to moderate increase in the production of thrombin within their bodies.

    Regular testing and diagnosing the mutation may help you identify the mutation and find appropriate treatment for it.

    Who Should Get Tested?

    It is recommended to get yourself tested if you have a family history of Factor V Leiden mutation. The risks of excessive clotting can vary from person to person. If you have previously suffered from blood clots, you are more likely at an increased risk of having another clot. The testing is specifically recommended if you are less than 50 years old, have unexplained blood clots, or have frequent episodes of deep venous thrombosis or venous thromboembolism.

    Medically reviewed by Dr. Soumya Bhattacharya, Haemotologist from Apollo Multispeciality Hospitals , Kolkata.

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    Unfortunately, there is no treatment for Factor V Leiden Mutation that can make the disorder disappear. However, there are ways in which you can reduce the chances of developing life-threatening blood clots. Medicines like anti-coagulants act like ‘blood-thinners’ and help prevent clotting. If you have frequent blood clotting, then you will need these medications. However, if you do not experience recurring blood clots, you may not need ‘blood-thinners’.
    Yes, you can pass on Factor V Leiden Mutation to your offspring. A child has a 50% chance of inheriting the Factor V Leiden gene if the parent has a heterozygous type. If the parent has a homozygous kind, the child will get the Factor V Leiden gene. Whether the child receives a homozygous or heterozygous type depends on the gene they inherit, i.e., Factor V or Factor V Leiden.
    If you have faced severe illnesses or casts and surgeries, you will have a higher risk of blood clots. Other conditions like diabetes can also increase the risk. Women are at a higher risk of developing blood clots during pregnancy. Women must consult their doctor before trying to get pregnant to know how to manage their blood clots during pregnancy better. Additionally, hormone or blood control pills increase the risk of blood clots. It is recommended for individuals to inform their healthcare providers or doctors about any medical conditions that they may suffer from.
    While there is no specific treatment to keep the blood clots away, you can always practice preventive measures to ensure they are under control. Keep your weight in check and if you are overweight or obese, consider losing some weight and staying within the range. Make physical activity an essential part of your life. Avoid smoking or consuming alcohol and take precautions when travelling long distances.

    Why should Apollo be your preferred healthcare partner?

    • 36 Years of legacy and credibility in the healthcare industry.
    • NABL certified multi-channel digital healthcare platform.
    • Affordable diagnostic solutions with timely and accurate test results.
    • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
    • An inventory of over 100+ laboratories, spread across the country, operating out of 50+ cities with 700+ collection centres, serving over 1800+ pin codes.

    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results

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