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Sifate 500mg Oral Suspension belongs to a gastrointestinal class of drugs called 'ulcer protectants' primarily used to prevent or treat peptic ulcers or gastrointestinal ulcers. A peptic ulcer is a sore on the stomach's lining or the first part of the small intestine (duodenum). Ulcer or sores of the stomach region is called gastric ulcer, while ulcer of the duodenum is known as duodenal ulcer.
Sifate 500mg Oral Suspension contains 'Sucralfate', which works by forming a protective barrier or coat over the ulcer so that digestive enzymes, acid and bile salts cannot further irritate the lining of the stomach and duodenum. This protects the ulcer from the stomach's acid, allowing it to heal.
Your doctor will advise you on how often you take Sifate 500mg Oral Suspension based on your medical condition. Some people may experience common side effects like constipation, dizziness, sleepiness, dry mouth, blurred vision, and diarrhoea. Most of these side effects of Sifate 500mg Oral Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Avoid taking any antacid like magnesium hydroxide or aluminium hydroxide within 30 minutes before or after taking Sifate 500mg Oral Suspension. If you are known to be allergic to Sifate 500mg Oral Suspension or active and inactive ingredients present on it, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Sifate 500mg Oral Suspension. Duodenal ulcer tends to be a recurrent disease. Try not to stop taking Sifate 500mg Oral Suspension of your own. Stopping a sudden intake of Sifate 500mg Oral Suspension will not influence the frequency or severity of future ulceration. Let your doctor know if you have any kidney problems. People with reduced kidney function may be more likely to experience side effects of aluminium accumulation with Sifate 500mg Oral Suspension. The dose adjustment is necessary for patients with kidney disease and elderly patients.
Sifate 500mg Oral Suspension is a class of an anti-ulcer drugs prescribed for treating or preventing the return of duodenal ulcers (ulcers located in the first part of the small intestines). Sifate 500mg Oral Suspension works by forming a protective barrier or coat over the ulcer to pepsin and bile and inhibits the diffusion of gastric acid. This protects the ulcer from the stomach's acid, allowing it to heal. Sifate 500mg Oral Suspension exhibits a cytoprotective effect and forms a viscous, adhesive barrier on the surface of the intact intestinal mucosa and the stomach. Sifate 500mg Oral Suspension stimulates the synthesis and release of gastric mucosal prostaglandins, bicarbonate, and the epidermal growth factor, which promotes healing.
You should avoid taking Sifate 500mg Oral Suspension if you are allergic to Sifate 500mg Oral Suspension or other ingredients present in it, have kidney disease, stomach/intestine problems (delayed gastric emptying), are pregnant or planning for pregnancy, and are a breastfeeding mother. Caution is required before giving Sifate 500mg Oral Suspension to elderly patients. Sifate 500mg Oral Suspension contains aluminium, which is normally removed by your kidney. Therefore, older adults and people with kidney problems may be at greater risk for developing high aluminium levels while using this drug with other products containing aluminium (e.g. antacids). The safety and effectiveness in children are not established; please consult your doctor before giving Sifate 500mg Oral Suspension to children.
Drug-Drug Interactions: Sifate 500mg Oral Suspension interacts with the anti-HIV drug (dolutegravir), vitamin D analogues (doxercalciferol, paricalcitol), antibiotic (ciprofloxacin, gemifloxacin, levofloxacin), antidiabetic (acarbose, metformin, glipizide, glimepiride, glyburide), antacid drug (magaldrate, aluminium hydroxide) blood thinner (warfarin).
Drug-Food Interactions: Drinking alcohol and nicotine (tobacco) with Sifate 500mg Oral Suspension may cause dehydration and elevate the level of stomach acid, thereby decreasing Sifate 500mg Oral Suspension efficacy.
Drug-Disease Interactions: Before taking Sifate 500mg Oral Suspension, inform your doctor if you have any kidney or liver disease as a dose of Sifate 500mg Oral Suspension needs to be adjusted.
Sifate 500mg Oral Suspension is prescribed for acute or short-term conditions of duodenal ulcer. Do not take Sifate 500mg Oral Suspension for more than eight weeks. If still, your duodenal ulcer persists, stop taking Sifate 500mg Oral Suspension and contact a doctor. Sifate 500mg Oral Suspension contains aluminium, so if you are a kidney patient, let your doctor know about this before taking Sifate 500mg Oral Suspension.
Duodenal ulcer: It is a sore that forms in the lining of the small intestine just beyond the stomach (duodenum). The stomach makes a strong acid that kills germs and helps you digest food. To protect themselves against this acid, duodenum cells make a barrier from mucus. If this barrier is damaged, an ulcer can form. The main cause of this barrier damage is infection with bacteria (H. pylori), medicines like NSAIDs or painkillers (aspirin, ibuprofen). If you have a duodenum ulcer, you might have symptoms like have pain in the stomach or abdomen (this might come and go and is relieved by taking an antacid), indigestion, nauseous, feeling full after taking a small amount of food, bloody or black stools.
Alcohol
Caution
Drinking alcohol with Sifate 500mg Oral Suspension may cause dehydration and elevate the level of stomach acid, thereby decreasing Sifate 500mg Oral Suspension efficacy.
Pregnancy
Safe if prescribed
Sifate 500mg Oral Suspension should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast Feeding
Caution
There is limited data on how Sifate 500mg Oral Suspension affects breastfeeding. Please consult your doctor, before taking Sifate 500mg Oral Suspension. Your doctor will weigh the benefits and any potential risks before prescribing them to you.
Driving
Caution
Sifate 500mg Oral Suspension decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Liver
Caution
Sifate 500mg Oral Suspension to be taken with caution if you had or have a history of liver disease/conditions. The dose may have to be adjusted by your doctor.
Kidney
Unsafe
Sifate 500mg Oral Suspension contains aluminium, which is normally excreted by your kidney. Therefore, people with kidney problems may be at greater risk of high aluminium toxicity in the body. The dose adjustment is necessary for patients with kidney disease.
Children
Caution
The safety and effectiveness of Sifate 500mg Oral Suspension in children have not been established. Please consult your doctor before giving Sifate 500mg Oral Suspension to children.
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