I was diagnosed with CML (chronic phase) in February and started Veenat 400 from March 6th, with my WBC counts remaining stable at around 5000 and my 6 month BCR ABL result being 0.953 percent. However, since July, I have been experiencing persistent mouth sores that have not improved with different remedies. My question is, what is the best way to manage this? Should I stop Veenat for a week and restart, switch to a second-generation drug, or temporarily move to a second generation drug and later return to the first generation one? My main concern is whether taking a break from Veenat will negatively affect my long term treatment goals and the possibility of achieving deep molecular remission at one year.

Answered by 1 Apollo Doctors

Dr Vasanthasree Nair

General Practitioner

MBBS
15+ Yrs

Consult Now

You have responded well to Veenat (Imatinib) with WBC stable and BCR ABL down to 0.953 percent that is a strong sign. Mouth sores are a known side effect and may worsen quality of life but usually do not need a full break. Option 2 or 3 (switching to 2nd gen TKIs) is preferable over stopping, to avoid resistance and relapse. Taking a temporary break should only be done under strict oncologist supervision.

Dr. Vasanthasree Suggests...

Take a CBC Test (Complete Blood Count) Test or Take a LFT (Liver Function) Test Test

Book CBC Test (Complete Blood Count) Test Book LFT (Liver Function) Test Test

Answered 10/09/2025

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