I'm dealing with some mild acanthosis nigricans on my hands and neck, and I'm really hoping to get some advice on the best medication available to help with this. What treatments are usually recommended for someone with my symptoms?

Dr Anshul Maheshwari

General Practitioner

• MBBS
• 5+ Yrs

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Acanthosis nigricans (AN) treatment focuses on addressing underlying causes and managing symptoms.

Topical Treatments

1. Retinoids: Derivatives of vitamin A, helping to reduce skin darkening and thickness.
2. Hydroquinone: Fades skin hyperpigmentation.
3. Salicylic acid: Exfoliates the skin, improving texture and tone.

Oral Medications

1. Metformin: For AN associated with insulin resistance or polycystic ovary syndrome (PCOS).
2. Insulin-sensitizing agents: Like pioglitazone, for improving insulin sensitivity.

Lifestyle Changes

1. Weight management: Maintaining a healthy weight can help improve insulin sensitivity and reduce AN symptoms.
2. Exercise regularly: Improves insulin sensitivity and overall health.
3. Balanced diet: Focus on whole, nutrient-dense foods to support overall health.

Natural Remedies

1. Tea tree oil: Has antimicrobial and anti-inflammatory properties, which may help soothe and calm the skin.
2. Aloe vera: May help reduce inflammation and promote skin

Answered 04/07/2025