I'm really worried about my syphilis tests. About two months ago, my TPHA level was 1320 and RPR was 12. My doctor put me on doxycycline, 100 mg twice a day for 21 days. After finishing the treatment, I tested again and my TPHA had increased to 1640, with the RPR still at 12. They then gave me a penicillin injection, 2.4 mu, and told me to get tested after another two weeks. This time, my results were TPHA 1640 again, but RPR went up to 14. I even did a test at a different lab and the TPHA was 12560 there. I'm scared and not sure what's going on. Can you help me understand these results?

Answered by 1 Apollo Doctors

Dr Dhankecha Dineshbhai

General Practitioner

MBBS
6+ Yrs

Consult Now

Your test results indicate a persistent syphilis infection, and the treatment outcomes are concerning; the increasing RPR titers (1:2 to 1:4) and varying TPHA results (1:320 to 1:640 to 1:2560) suggest that the infection may not be responding to the treatments administered; consult a specialist,

Dr. Dhankecha Suggests...

Consult a Infectious Disease specialist

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Answered 04/07/2025

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