apollo
  • Male
  • 35 Years
  • 05/06/2023

What causes congenital adrenal hyperplasia?

Doctor 1

Answered by 1 Apollo Doctors

The most common cause of congenital adrenal hyperplasia is a genetic mutation. This occurs when there is a change in the 21-hydroxylase enzyme. The adrenal gland needs 21-hydroxylase to make adequate amounts of hormones. If the body is deficit of 21-hydroxylase, which is also known as 21-hydroxylase deficiency, this can result in decreased cortisol production.

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Answered 24/07/2025

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