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Crohn's vs. Ulcerative Colitis Symptoms

Discover the similarities and differences between Crohn’s disease and ulcerative colitis and why adequate symptom recognition and management are vital for patients.

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Last updated on 3rd Jul, 2025

Inflammatory bowel disease (IBD) is a group of chronic disorders that leads to inflammation in the digestive tract. Crohn’s disease and ulcerative colitis are two basic types of IBD that affect the gastrointestinal (GI) tract in a very severe manner. While these two conditions have similarities, they also have their differences. They have similar signs and symptoms but manifest differently and involve different regions of the digestive system. An understanding of their differences and similarities is essential to diagnose, treat, and manage the two conditions well. 

Similarities in Symptoms

Though Crohn’s disease has different characteristics than ulcerative colitis, they exhibit similar symptoms and differentiating is tough. The following are some of the common symptoms they both share:

  • Common Gastrointestinal Symptoms

Both conditions lead to symptoms that affect the gastrointestinal tract, such as diarrhoea, abdominal pain, bloating, and blood or mucus passing in the faeces due to inflammation in the digestive tract.

  • Extra-intestinal Symptoms

Due to immunologic phenomena, other complaints, such as arthritis, rash, conjunctivitis, or anaemia, may be present in Crohn’s disease or ulcerative colitis.

  • Fatigue and Weight Loss

Patients with both Crohn’s disease and ulcerative colitis suffer from fatigue and weight loss as a result of chronic inflammation, malabsorption, and anaemia.

  • Fever and Night Sweats

Low-grade fever and sweating at night are other symptoms that the patients may have. They occur during flare-ups as part of the body’s inflammatory response.

Crohn's Disease-Specific Symptoms

Crohn’s disease is different from other inflammatory types of bowel disease because it has some specific symptoms. The following are considered specific and primary local gastrointestinal as well as systemic manifestations of Crohn’s disease:

1. Gastrointestinal Symptoms

In addition to abdominal pain and diarrhoea, Crohn’s disease can cause: 

  • Nausea,

  • Vomiting

  • Bloating

  • Some of the serious consequences include stricture formation, fistula formation, and malabsorption.

2. Systemic Symptoms

Systemic symptoms of Crohn's disease include: 

  • Fatigue

  • Fever

  • Weight loss

  • Anaemia

  • Complaints that are not related to the digestive tract include joint pains, skin rashes, and eye inflammation.

Ulcerative Colitis Specific Symptoms

Ulcerative colitis has individual characteristics that distinguish it from other types of IBD. The particular gastrointestinal and systemic signs of ulcerative colitis are: 

1. Gastrointestinal Symptoms

  • Persistent diarrhoea, often with blood or mucus

  • Abdominal cramping and discomfort

  • Urgency to have bowel movements

  • Rectal bleeding and ulcerations in the colon

  • Tenesmus (feeling of incomplete evacuation)

2. Systemic Symptoms

  • Fatigue and general weakness

  • Unexplained weight loss

  • Low-grade fever during flare-ups

  • Joint pain and swelling (extra-intestinal)

  • Skin rashes and eye inflammation (extra-intestinal)

Potential Complications

Crohn’s disease and ulcerative colitis pose certain complications, some of which are specific to each disease. Here is detailed information on complications related to each disease:

1. Complications Specific to Crohn's Disease

  • Fistulas and Abscesses: Crohn’s disease results in fistulas and abscesses and therefore causes infection.

  • Small Bowel Obstruction: Peritoneal adhesion may also lead to inflammation and scarring, blockage in the small intestines, and pain and vomiting. In serious cases of small bowel obstruction, surgery becomes important to help the patient recover.

  • Perforation of the Bowel: A high inflammation level can lead to bowel perforation. This is a health emergency that can be fatal, so individuals need to consult a doctor immediately. 

  • Malnutrition and Nutritional Deficiencies: Since the disease can impact any area of the gastrointestinal system, it interferes with food absorption, causing a deficiency in some essential nutrients. 

2. Complications Specific to Ulcerative Colitis

  • Toxic Megacolon: Profound inflammation can progress to an extensive dilation of the colon. It can cause the colon to rupture and lead to life-threatening situations.

  • Colon Cancer: Chronic inflammation in the colon with this disease increases the probability of colon cancer. That is why regular screening is very important for early diagnosis and timely intervention.

  • Severe Bleeding: This condition may lead to rectal bleeding due to the ulcers present in the colon and may need blood transfusion and surgery.

  • Electrolyte Imbalance: Since the patients suffer from diarrhoea and fluid stool, there may be an electrolyte imbalance, which will affect the functioning of the heart and other organs.

Diagnosis and Symptom Assessment

Correct diagnosis and repeated symptom monitoring are critical for treating and managing a patient with Crohn’s disease or ulcerative colitis. The diagnostic tests used and methods for monitoring disease progression are: 

1. Diagnostic Tests

  • Colonoscopy and Endoscopy: These are some important techniques used to inspect the colon and upper gastrointestinal tract for direct indication of inflammation, ulcers, or other symptoms.

  • Imaging Techniques: Plain X-rays, CT scans, and MRIs are employed to determine the severity of inflammation, look for complications, or exclude other conditions.

  • Blood Tests: Blood tests help to identify complete blood count for anaemia, inflammatory markers (C-reactive proteins), and infection indicators.

  • Stool Tests: Stool samples help diagnose infections, bloody diarrhoea, and inflammation in the digestive tract.

2. Monitoring Disease Progression

  • Regular Colonoscopies: Regular follow-up colonoscopies are required to monitor the activities of the disease and look for complications and endoscopic evidence of colon cancer in long-standing cases.

  • Symptom Tracking: The sufferers are advised to observe the frequency of diarrhoea, stomach ache, and weight loss to determine the severity of the disease.

  • Inflammatory Markers: A blood test checks for inflammatory markers or enzymes that can help to determine whether the condition is active or at a more quiescent stage.

  • Nutritional Assessments: Nutrient deficiencies pose serious risks and therefore, routine assessments of nutrient status should be done to identify any problem that may require changes to the treatment plan.

Importance of Symptom Recognition and Management

So, the proper assessment and treatment of symptoms play a significant role in enhancing the results of Crohn’s disease and ulcerative colitis. Effective symptom management stabilises performance, diminishes suffering during the day, and helps people become less emotionally stressed and gain more freedom to lead a vigorous life. Early detection is central in minimising serious side effects and extent of harm since early treatment lowers the chances of hospitalisation besides aiding the management of the ailment. By detecting symptoms early enough and ensuring proper treatment, the patients can enhance their quality of life and control the disease. 

Conclusion

Understanding the differences and similarities between Crohn’s disease and ulcerative colitis is crucial for accurate diagnosis, effective treatment, and long-term management. While both conditions share common symptoms, their distinct characteristics require tailored medical approaches. Early detection, symptom monitoring, and proactive management can help patients maintain a better quality of life and prevent serious complications associated with these chronic inflammatory bowel diseases.

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Dr Harish K C, Gastroenterology/gi Medicine Specialist

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Gastroenterology/gi Medicine Specialist

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Bangalore

Manipal Hospital, Bangalore

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