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Understanding Autophagy in Fasting.

Know about autophagy in fasting, how fasting triggers, types and benefits of autophagy and more.

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Written by Dr. Siri Nallapu

Reviewed by Dr. J T Hema Pratima MBBS

Last updated on 31st Jul, 2025

Introduction 

Have you ever wondered why fasting is often linked to better health? One of the key reasons is autophagy, a natural process in your body that helps clean out damaged cells and regenerate new, healthy ones. If you're curious about how fasting can boost autophagy and improve your well-being, this article is for you!

What is Autophagy?

Autophagy (pronounced aw-TAH-fuh-jee) is your body’s way of cleaning house. The word comes from Greek, meaning "self-eating," but don’t worry—it’s a good thing! It’s a process where your cells break down and recycle old, damaged, or unnecessary components to make way for fresh, healthy ones.

Think of it like a spring cleaning for your cells—removing junk, repairing damage, and keeping everything running smoothly.

How Does Fasting Trigger Autophagy?

Your body switches into autophagy mode when it’s not busy digesting food. When you fast (stop eating for a certain period), your insulin levels drop, and your cells start looking for alternative energy sources. This triggers autophagy, where they recycle damaged proteins and cellular waste to generate energy.

Consult a general practitioner for the best advice

Dr. Tanmaya Kumar Sahu, General Physician/ Internal Medicine Specialist

Dr. Tanmaya Kumar Sahu

General Physician/ Internal Medicine Specialist

12 Years • MBBS, MD ( Internal Medicine )

Bhubaneswar

Apollo Hospitals Old Sainik School Road, Bhubaneswar

800

800

No Booking Fees

Types of Fasting That Boost Autophagy:

Various types of fasting to boost autophagy:

  1. Intermittent Fasting (IF): Eating within a specific window (e.g., 16:8—fast for 16 hours, eat in an 8-hour window).

  2. Extended Fasting: Fasting for 24 hours or more (under medical supervision if needed).

  3. Water Fasting: Consuming only water for a set period.

Health Benefits of Autophagy

Autophagy isn’t just about cellular cleanup—it has several health benefits:

1. Supports Longevity: Helps slow down ageing by removing damaged cells.

2. Boosts Immunity: Clears out harmful bacteria and viruses.

3. Protects Against Diseases: May reduce the risk of Alzheimer’s, cancer, and diabetes.

4. Improves Metabolism: Helps regulate blood sugar and fat breakdown.

5. Enhances Brain Function: Supports neuron health and cognitive function.

Signs Autophagy is Happening

While you can’t "feel" autophagy directly, some signs may indicate it’s working:

  1. Increased energy levels

  2. Better mental clarity

  3. Reduced inflammation

  4. Improved digestion

How to Maximise Autophagy Through Fasting

If you want to enhance autophagy, here are some simple tips:

1. Start with Intermittent Fasting

  • Begin with a 12-hour fast (e.g., stop eating at 8 PM, eat again at 8 AM).

  • Gradually increase to 14-16 hours.

2. Stay Hydrated

Drink plenty of water, herbal teas, or black coffee (no sugar).

3. Eat Nutrient-Dense Foods

After fasting, focus on whole foods like vegetables, lean proteins, and healthy fats.

4. Exercise Moderately

Light exercise (walking, yoga) can help stimulate autophagy.

5. Get Enough Sleep

Quality sleep supports cellular repair and autophagy.

Who Should Be Cautious with Fasting?

While fasting is beneficial for many, it may not be suitable for:

  • Pregnant or breastfeeding women

  • People with diabetes (consult a doctor first)

  • Those with a history of eating disorders

  • Individuals on certain medications

If you have any health concerns, it’s best to consult a doctor before starting a fasting routine.

When to Seek Medical Advice

If you experience dizziness, extreme fatigue, or other unusual symptoms while fasting, stop and seek medical advice.

Final Thoughts

Autophagy is a powerful natural process that helps keep your body healthy and resilient. By incorporating fasting into your lifestyle wisely, you can support cellular repair, improve energy, and enhance overall well-being.

Consult a general practitioner for the best advice

Dr. Tanmaya Kumar Sahu, General Physician/ Internal Medicine Specialist

Dr. Tanmaya Kumar Sahu

General Physician/ Internal Medicine Specialist

12 Years • MBBS, MD ( Internal Medicine )

Bhubaneswar

Apollo Hospitals Old Sainik School Road, Bhubaneswar

800

800

No Booking Fees

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Dr. Suvadeep Sen, Critical Care Specialist

Dr. Suvadeep Sen

Critical Care Specialist

12 Years • MBBS, MD, FNB (CRITICAL CARE MEDICINE), EDIC

Mumbai

Apollo Hospitals CBD Belapur, Mumbai

2300

200 Cashback

2300

No Booking Fees

Dr. Tanmaya Kumar Sahu, General Physician/ Internal Medicine Specialist

Dr. Tanmaya Kumar Sahu

General Physician/ Internal Medicine Specialist

12 Years • MBBS, MD ( Internal Medicine )

Bhubaneswar

Apollo Hospitals Old Sainik School Road, Bhubaneswar

800

800

No Booking Fees

Dr. Minakshi Dutta, General Practitioner

Dr. Minakshi Dutta

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Bengaluru

Trini Healthcare Clinic | Healing, Health & Happiness, Bengaluru

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Dr. Yamini Miglani, General Practitioner

Dr. Yamini Miglani

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AAKASH MEDSQUARE, New Delhi

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