Normal Creatinine Clearance Explained
Know what is creatinine clearance, causes of it, symptoms and how to improve the creatinine clearance through management and tips.
Written by Dr. Mohammed Kamran
Reviewed by Dr. Dhankecha Mayank Dineshbhai MBBS
Last updated on 25th Jul, 2025
Introduction
When it comes to kidney health, one term you might hear from your doctor is "creatinine clearance." While it may sound complex, understanding what it means can help you take better care of your kidneys. In this article, we’ll break down what normal creatinine clearance is, why it matters, and how you can maintain healthy kidney function.
What Is Creatinine Clearance?
Creatinine is a waste product produced by your muscles during normal activity. Your kidneys filter creatinine from your blood and remove it through urine. Creatinine clearance is a test that measures how well your kidneys are working by checking how efficiently they remove creatinine from your blood.
A normal creatinine clearance rate means your kidneys are functioning well and effectively filtering waste.
What Is a Normal Creatinine Clearance Range?
The normal range for creatinine clearance varies slightly based on age, gender, and muscle mass, but generally:
For adult men: 90–140 mL/min
For adult women: 80–125 mL/min
For older adults: Slightly lower due to natural ageing
If your creatinine clearance is within this range, your kidneys are likely working properly. If it’s too low, it could indicate kidney dysfunction.
Why Is Creatinine Clearance Important?
Your kidneys play a crucial role in:
Filtering waste and toxins from your blood
Balancing fluids and electrolytes
Regulating blood pressure
If your creatinine clearance is abnormal, it may signal kidney disease, dehydration, or other health issues. Early detection helps in managing kidney health before complications arise.
Symptoms of Abnormal Creatinine Clearance
If your kidneys aren’t filtering well, you may experience:
Fatigue or weakness
Swelling in legs, ankles, or face (oedema)
Changes in urination (frequent or reduced urine output)
High blood pressure
Nausea or loss of appetite
If you notice these symptoms, consult a doctor for further evaluation.
Consult a Top nephrologist for the best advice
What Causes Low Creatinine Clearance?
Several factors can affect kidney function, including:
Chronic kidney disease (CKD)
Diabetes or high blood pressure (leading causes of kidney damage)
Dehydration
Urinary tract blockages (kidney stones, enlarged prostate)
Certain medications (NSAIDs, some antibiotics)
How to Maintain a Healthy Creatinine Clearance
1. Stay Hydrated
Drinking enough water helps your kidneys flush out toxins. Aim for 8–10 glasses a day, unless your doctor advises otherwise.
2. Eat a Kidney-Friendly Diet
Reduce sodium (avoid processed foods, excess salt)
Limit protein (too much can strain the kidneys)
Eat more fruits & vegetables (rich in antioxidants)
3. Control Blood Pressure & Blood Sugar
High BP and diabetes are major risk factors for kidney disease. Regular check-ups and medication adherence can help.
4. Avoid Overuse of Painkillers
Excessive use of NSAIDs (like ibuprofen) can harm the kidneys. Use them only when necessary.
5. Exercise Regularly
Moderate physical activity supports overall kidney and heart health.
When Should You Get Tested?
Your doctor may recommend a creatinine clearance test if:
You have diabetes or high blood pressure
You experience kidney-related symptoms
You’re on medications that affect kidney function
Final Thoughts
A normal creatinine clearance is a good sign that your kidneys are functioning well. However, if your levels are abnormal, early intervention can help prevent further damage. Simple lifestyle changes—like staying hydrated, eating right, and managing chronic conditions—can go a long way in protecting your kidney health.
Consult a Top nephrologist for the best advice
Consult a Top nephrologist for the best advice
Dr. S Bipin Kumar
Nephrologist
13 Years • MBBS, MD General Medicine, DM, Nephrology
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SG KIDNEY CARE, Rajamahendravaram
Dr. Govardhan Gupta
Nephrologist
15 Years • MBBS, DNB General Medicine, DrNB Nephrology
Mumbai
Oscar Superspeciality Hospital, Mumbai
Dr. Luvdeep Dogra
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10 Years • MBBS, MD, DM (NEPHORLOGY)
Jaipur
Dr Dogras Health Clinic, Jaipur
Dr. Anantha Rao
Nephrologist
7 Years • MBBS, DNB (General Medicine), DNB (Nephrology)
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Aakash hospital and KIMS hospital, Kurnool
Dr. Siddharth Herur
Nephrologist
4 Years • MBBS, MD General Medicine, DM Nephrology
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Medicover hospital and Gurudatta poly clinic, Kurnool
