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Uncommon Symptoms of B12 Deficiency Explained

know the uncommon B12 symptoms, who is at risk and how to manage and prevent the B12 deficiency and more.

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Written by Dr. D Bhanu Prakash

Reviewed by Dr. Siri Nallapu MBBS

Last updated on 31st Jul, 2025

Introduction 

Vitamin B12 is a crucial nutrient that keeps our nerves, blood cells, and DNA healthy. While fatigue, weakness, and numbness are well-known signs of B12 deficiency, there are some unusual symptoms that often go unnoticed. If left untreated, a B12 deficiency can lead to serious health problems. Let’s explore these uncommon signs and understand how to manage them effectively.

What Is Vitamin B12 Deficiency?

Vitamin B12 (cobalamin) is essential for nerve function, red blood cell production, and DNA synthesis. Our body doesn’t make B12 naturally, so we rely on food (meat, dairy, eggs) or supplements. A deficiency occurs when:

  • The body doesn’t absorb enough B12 (due to conditions like pernicious anemia or gut disorders).

  • Dietary intake is insufficient (common in vegetarians/vegans).

  • Certain medications (like metformin or acid reducers) interfere with absorption.

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Uncommon Symptoms of B12 Deficiency

Most people associate B12 deficiency with tiredness or tingling hands and feet. However, some lesser-known symptoms may surprise you:

1. Brain Fog & Memory Problems

  •  Difficulty concentrating, forgetfulness, or confusion.

  •  Often mistaken for early dementia or aging.

2. Mood Swings & Depression

  • B12 helps produce serotonin (the "happy hormone").

  • Low levels can cause irritability, anxiety, or depression.

3. Strange Sensations (Pins & Needles or Burning Feet)

Nerve damage from B12 deficiency may cause tingling, burning, or electric shock-like sensations.

4. Glossitis (Sore, Red Tongue)

  •  A swollen, smooth, or beefy-red tongue.

  •  May cause pain while eating or speaking.

 5. Vision Problems

 Blurred or double vision due to optic nerve damage.

 6. Balance Issues & Dizziness

 Poor coordination, stumbling, or feeling lightheaded.

7.  Pale or Yellowish Skin

Lack of healthy red blood cells can lead to jaundice-like discoloration.

8. Heart Palpitations

Low B12 affects red blood cell production, leading to irregular heartbeats.

9. Unexplained Weight Loss

Digestive issues from B12 deficiency may reduce appetite.

10. Mouth Ulcers & Cracks at Corners of Mouth

Persistent sores or angular cheilitis (cracked lips).

Who Is at Risk?

Certain groups are more prone to B12 deficiency:

  •  Vegetarians/Vegans (B12 is mainly found in animal products).

  •  Older Adults (stomach acid decreases with age, reducing absorption).

  •  People with Gut Disorders (Crohn’s disease, celiac disease, or gastric bypass surgery).

  •  Long-term Medication Users (acid reducers, metformin).

How to Manage & Prevent B12 Deficiency

1. Dietary Sources

  • Animal-based: Meat, fish, eggs, dairy.

  • Fortified foods: Plant-based milk, cereals (for vegetarians/vegans).

2. Supplements

  • Oral B12 tablets or sublingual (under-the-tongue) drops.

  •  Injections (if absorption is poor—consult a doctor).

3. Regular Testing

  •  A simple blood test can check B12 levels.

  •  If symptoms persist, further tests (like MMA or homocysteine levels) may be needed.

4. Lifestyle Adjustments

  • Reduce alcohol (it affects B12 absorption).

  • Manage gut health (probiotics may help).

When to See a Doctor?

If you experience any unusual symptoms, especially if you’re in a high-risk group, consult a doctor. Untreated B12 deficiency can lead to:

  • Permanent nerve damage

  • Severe anemia

  • Increased risk of heart disease

Final Thoughts

Vitamin B12 deficiency is more common than we think, and its symptoms aren’t always obvious. If you’re feeling unusually tired, forgetful, or experiencing strange nerve sensations, it’s worth getting checked. With the right diet, supplements, and medical guidance, you can restore your B12 levels and feel your best again.

Consult Top Nutritionists

Dr. Bhukya Pavan Kalyan, General Physician

Dr. Bhukya Pavan Kalyan

General Physician

5 Years • MBBS DNB Paediatrics

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Dr Sumanth R, General Physician

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Consult Top Specialists for Personalised Tips

Dr. Bhukya Pavan Kalyan, General Physician

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General Physician

5 Years • MBBS DNB Paediatrics

Bengaluru

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Dr. Ramalinga Reddy, General Physician

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Dr Sumanth R, General Physician

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Ms. Lakshmi Tejasvi, Clinical Nutritionist

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Consult Top Nutritionists

Dr. Bhukya Pavan Kalyan, General Physician

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General Physician

5 Years • MBBS DNB Paediatrics

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

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Dr. Ramalinga Reddy, General Physician

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Dt. Ila Sharma, Clinical Nutritionist

Dt. Ila Sharma

Clinical Nutritionist

18 Years • Master in food & Nutrition

Gurugram

VIPUL GREENS - SOCIETY CLINIC, Gurugram

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Dr Sumanth R, General Physician

Dr Sumanth R

General Physician

2 Years • MBBS

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

400

60 Cashback

Ms. Lakshmi Tejasvi, Clinical Nutritionist

Ms. Lakshmi Tejasvi

Clinical Nutritionist

14 Years • M.Sc - Clinical Nutrition

Hyderabad

Vibgyor Nutri, Hyderabad

750

No Booking Fees

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