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Understanding Amyotrophic Lateral Sclerosis

Learn about Amyotrophic Lateral Sclerosis (ALS), its symptoms, causes, effects on daily life, and available treatment options to better understand and manage this progressive neurological condition.

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Written by Dr. M L Ezhilarasan

Reviewed by Dr. Md Yusuf Shareef MBBS

Last updated on 28th Aug, 2025

amyotrophic lateral sclerosis

Introduction

Amyotrophic Lateral Sclerosis (ALS), often referred to as Lou Gehrig's disease, is a rare but serious neurological condition that affects the nerve cells responsible for controlling voluntary muscle movements. Over time, ALS leads to muscle weakness, difficulty speaking and swallowing, and eventually, breathing problems. While there is currently no cure for ALS, understanding the condition, its symptoms, and available treatments can help patients and their families manage it better.

What is ALS?

ALS is a progressive neurodegenerative disease that damages motor neurons, the nerve cells in the brain and spinal cord that control muscle movement. As these neurons deteriorate, the brain loses its ability to initiate and control muscle movement, leading to muscle weakness, paralysis, and, in later stages, difficulty breathing.

Consult a Neurologist for the best advice

Dr. Avinash Gupta, Neurologist

Dr. Avinash Gupta

Neurologist

12 Years • MBBS, DNB - Neurology

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

82%

(150+ Patients)

800

800

Dr. Joydeep Biswas, Neurologist

Dr. Joydeep Biswas

Neurologist

15 Years • MBBS, DNB General Medicine, DNB Neurology

Barasat

Diab-Eat-Ease, Barasat

900

Dr. Uddalak Chakraborty, Neurologist

Dr. Uddalak Chakraborty

Neurologist

8 Years • MBBS, MD(GENL.MED.),DM(NEUROLOGY)

Kolkata

MCR SUPER SPECIALITY POLY CLINIC & PATHOLOGY, Kolkata

recommendation

81%

(25+ Patients)

1200

1150

Dr. Aditendraditya Singh Bhati, Neurosurgeon

Dr. Aditendraditya Singh Bhati

Neurosurgeon

21 Years • MBBS(2004), DNB Neurosurgery(2014); MNAMS; Fellow Skull Base Endoscopy (Italy), Fellow Extended Skull Base ( Weill Cornell, USA), Fellow ZAP-X Radiosurgery. Member of American Association of Neurological Surgeons

Delhi

Apollo Hospitals Indraprastha, Delhi

recommendation

85%

(100+ Patients)

1200

1500

Symptoms of ALS

The symptoms of ALS vary from person to person, but they generally worsen over time. Common early signs include:

  • Muscle weakness – Often starting in the hands, arms, legs, or feet.
  • Difficulty walking – Tripping, stumbling, or dragging one foot.
  • Slurred speech – Trouble speaking clearly or swallowing.
  • Muscle cramps and twitching – Especially in the arms, shoulders, or tongue.
  • Difficulty with fine motor skills – Such as buttoning a shirt or holding objects.

As the disease progresses, symptoms may include:

  • Severe muscle atrophy (shrinking).
  • Difficulty breathing due to weakened respiratory muscles.
  • Loss of the ability to speak, eat, or move independently.

Causes and Risk Factors

The exact cause of ALS is still unknown, but researchers believe a combination of genetic and environmental factors may contribute. Some known risk factors include:

  • Genetics – About 5-10% of ALS cases are inherited (familial ALS).
  • Age – Most people diagnosed with ALS are between 40 and 70 years old.
  • Gender – Men are slightly more likely to develop ALS than women.
  • Smoking and environmental toxins – Some studies suggest a link between smoking, heavy metal exposure, and ALS.

How ALS Affects Daily Life

Living with ALS can be challenging, both physically and emotionally. As muscle control declines, everyday activities like walking, eating, and speaking become difficult. Many patients require assistive devices such as wheelchairs, speech-generating devices, or feeding tubes. Despite these challenges, many people with ALS maintain a good quality of life with the right support and care.

Managing ALS: Treatment and Support

While there is no cure for ALS, treatments can help manage symptoms and improve quality of life. Some key approaches include:

Medical Treatments

  • Medications – Drugs like Riluzole and Edaravone may slow disease progression.
  • Physical therapy – Helps maintain muscle strength and mobility.
  • Speech therapy – Assists with communication and swallowing difficulties.
  • Respiratory support – Breathing devices like ventilators may be needed in later stages.

Lifestyle and Home Care

  • Healthy diet – Soft or liquid foods may be necessary if swallowing is difficult.
  • Exercise – Gentle activities like stretching can help maintain flexibility.
  • Emotional support – Counseling or support groups can help patients and families cope.

When to See a Doctor

If you or a loved one experience persistent muscle weakness, difficulty speaking, or unexplained twitching, it’s important to consult a neurologist. Early diagnosis can help in managing symptoms more effectively.

Final Thoughts

ALS is a challenging condition, but with the right medical care, support, and lifestyle adjustments, patients can maintain a meaningful life. If you or someone you know is experiencing symptoms, don’t hesitate to seek medical advice. Early intervention can make a significant difference in managing the disease.

Consult a Neurologist for the best advice

Dr. Avinash Gupta, Neurologist

Dr. Avinash Gupta

Neurologist

12 Years • MBBS, DNB - Neurology

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

82%

(150+ Patients)

800

800

Dr. Joydeep Biswas, Neurologist

Dr. Joydeep Biswas

Neurologist

15 Years • MBBS, DNB General Medicine, DNB Neurology

Barasat

Diab-Eat-Ease, Barasat

900

Dr. Uddalak Chakraborty, Neurologist

Dr. Uddalak Chakraborty

Neurologist

8 Years • MBBS, MD(GENL.MED.),DM(NEUROLOGY)

Kolkata

MCR SUPER SPECIALITY POLY CLINIC & PATHOLOGY, Kolkata

recommendation

81%

(25+ Patients)

1200

1150

Dr. Aditendraditya Singh Bhati, Neurosurgeon

Dr. Aditendraditya Singh Bhati

Neurosurgeon

21 Years • MBBS(2004), DNB Neurosurgery(2014); MNAMS; Fellow Skull Base Endoscopy (Italy), Fellow Extended Skull Base ( Weill Cornell, USA), Fellow ZAP-X Radiosurgery. Member of American Association of Neurological Surgeons

Delhi

Apollo Hospitals Indraprastha, Delhi

recommendation

85%

(100+ Patients)

1200

1500

Consult a Neurologist for the best advice

Dr. Avinash Gupta, Neurologist

Dr. Avinash Gupta

Neurologist

12 Years • MBBS, DNB - Neurology

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

82%

(150+ Patients)

800

800

Dr. Aleti Venkat Reddy, Neurologist

Dr. Aleti Venkat Reddy

Neurologist

14 Years • MBBS, MD (GEN MEDICINE), DM NEUROLOGY, FEAN

Secunderabad

Apollo Hospitals Secunderabad, Secunderabad

900

Dr. Joydeep Biswas, Neurologist

Dr. Joydeep Biswas

Neurologist

15 Years • MBBS, DNB General Medicine, DNB Neurology

Barasat

Diab-Eat-Ease, Barasat

900

Dr. Uddalak Chakraborty, Neurologist

Dr. Uddalak Chakraborty

Neurologist

8 Years • MBBS, MD(GENL.MED.),DM(NEUROLOGY)

Kolkata

MCR SUPER SPECIALITY POLY CLINIC & PATHOLOGY, Kolkata

recommendation

81%

(25+ Patients)

1200

1150

Dr. Aditendraditya Singh Bhati, Neurosurgeon

Dr. Aditendraditya Singh Bhati

Neurosurgeon

21 Years • MBBS(2004), DNB Neurosurgery(2014); MNAMS; Fellow Skull Base Endoscopy (Italy), Fellow Extended Skull Base ( Weill Cornell, USA), Fellow ZAP-X Radiosurgery. Member of American Association of Neurological Surgeons

Delhi

Apollo Hospitals Indraprastha, Delhi

recommendation

85%

(100+ Patients)

1200

1500

Consult a Neurologist for the best advice

Dr. Avinash Gupta, Neurologist

Dr. Avinash Gupta

Neurologist

12 Years • MBBS, DNB - Neurology

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

82%

(150+ Patients)

800

800

Dr. Aleti Venkat Reddy, Neurologist

Dr. Aleti Venkat Reddy

Neurologist

14 Years • MBBS, MD (GEN MEDICINE), DM NEUROLOGY, FEAN

Secunderabad

Apollo Hospitals Secunderabad, Secunderabad

900

Dr. Joydeep Biswas, Neurologist

Dr. Joydeep Biswas

Neurologist

15 Years • MBBS, DNB General Medicine, DNB Neurology

Barasat

Diab-Eat-Ease, Barasat

900

Dr. Uddalak Chakraborty, Neurologist

Dr. Uddalak Chakraborty

Neurologist

8 Years • MBBS, MD(GENL.MED.),DM(NEUROLOGY)

Kolkata

MCR SUPER SPECIALITY POLY CLINIC & PATHOLOGY, Kolkata

recommendation

81%

(25+ Patients)

1200

1150

Dr. Aditendraditya Singh Bhati, Neurosurgeon

Dr. Aditendraditya Singh Bhati

Neurosurgeon

21 Years • MBBS(2004), DNB Neurosurgery(2014); MNAMS; Fellow Skull Base Endoscopy (Italy), Fellow Extended Skull Base ( Weill Cornell, USA), Fellow ZAP-X Radiosurgery. Member of American Association of Neurological Surgeons

Delhi

Apollo Hospitals Indraprastha, Delhi

recommendation

85%

(100+ Patients)

1200

1500

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