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Anti-inflammatory Drugs and NSAIDs Overview

Learn about anti-inflammatory drugs and NSAIDs, how they work, their common uses, potential side effects, and important considerations for safe and effective pain and inflammation relief.

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Written by Dr. Md Yusuf Shareef

Reviewed by Dr. M L Ezhilarasan MBBS

Last updated on 3rd Sep, 2025

Anti-inflammatory Drugs and NSAIDs

If you’ve ever had a headache, joint pain, or swelling, chances are you’ve taken an anti-inflammatory medication like ibuprofen or aspirin. These drugs, known as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), are commonly used to relieve pain, reduce inflammation, and lower fever. But how do they work, and when should you use them? Let’s break it down in simple terms.

What Are Anti-inflammatory Drugs and NSAIDs?

Anti-inflammatory drugs help reduce inflammation (swelling, redness, and pain) in the body. NSAIDs are a specific type of anti-inflammatory medication that also helps with pain and fever. Some common NSAIDs include:

  • Ibuprofen (Advil, Motrin)
  • Naproxen (Aleve)
  • Aspirin (Bayer, Disprin)
  • Diclofenac (Voltaren)

There’s also another type called steroidal anti-inflammatory drugs (like prednisone), which are stronger and usually prescribed for severe conditions.

How Do NSAIDs Work?

When you get injured or have an illness, your body produces chemicals called prostaglandins, which cause pain, 
swelling, and fever. NSAIDs block an enzyme called COX (cyclooxygenase), which reduces prostaglandin production. 
This helps:

  • Relieve pain (headaches, muscle aches, menstrual cramps)
  • Reduce swelling (arthritis, sprains)
  • Lower fever (during infections)

Common Uses of NSAIDs

NSAIDs are often used for:

  • Muscle and joint pain (arthritis, back pain, sports injuries)
  • Headaches and migraines
  • Menstrual cramps
  • Fever
  • Minor injuries (sprains, strains)

Consult Top Specialists

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

450

No Booking Fees

Dr. Anand Ravi, General Physician

Dr. Anand Ravi

General Physician

2 Years • MBBS

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

400

Dr Syed Mateen Pasha, General Physician

Dr Syed Mateen Pasha

General Physician

2 Years • MBBS

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

400

Dr. D Bhanu Prakash, General Practitioner

Dr. D Bhanu Prakash

General Practitioner

10 Years • MBBS, AFIH, Advanced certificate in critical care medicine, Fellowship in critical care medicine

Hyderabad

Apollo 24|7 Clinic, Hyderabad

690

Dr. Sandhya Chandel, General Physician/ Internal Medicine Specialist

Dr. Sandhya Chandel

General Physician/ Internal Medicine Specialist

16 Years • MBBS, MD (Int. Med.), IDCCM

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

94%

(125+ Patients)

700

700

No Booking Fees

Potential Side Effects of NSAIDs

While NSAIDs are helpful, they can sometimes cause side effects, especially if taken for a long time or in high doses. Possible risks include:

  • Stomach problems: Heartburn, ulcers, or stomach bleeding
  • Kidney issues: Reduced kidney function in some cases
  • High blood pressure: May worsen hypertension
  • Heart risks: Long-term use may increase heart attack/stroke risk

Who Should Be Cautious with NSAIDs?

  • People with stomach ulcers or bleeding disorders
  • Those with kidney or heart disease
  • Elderly patients (higher risk of side effects)
  • Pregnant women (especially in the third trimester)

Always check with your doctor before taking NSAIDs if you have any chronic health conditions.

Tips for Safe Use of NSAIDs

To minimise risks, follow these guidelines:

  • Take the lowest effective dose: Don’t exceed the recommended amount.
  • Avoid long-term use: Unless prescribed by a doctor.
  • Take with food or milk: Reduces stomach irritation.
  • Stay hydrated: Helps protect kidneys.
  • Don’t mix with alcohol: Increases stomach bleeding risk.

Natural Ways to Reduce Inflammation

If you want to reduce reliance on NSAIDs, try these natural anti-inflammatory approaches:

  • Eat anti-inflammatory foods: Turmeric, ginger, fatty fish (salmon), leafy greens, berries.
  • Stay hydrated: Helps flush out toxins.
  • Exercise regularly: Reduces chronic inflammation.
  • Get enough sleep: Poor sleep increases inflammation.
  • Manage stress: Yoga, meditation, deep breathing help.

When to See a Doctor?

Consult a healthcare provider if:

  • Pain or swelling doesn’t improve after a few days.
  • You experience severe stomach pain, black stools (sign of bleeding), or unusual swelling.
  • You have high blood pressure, heart disease, or kidney problems.

Need Expert Advice?

If you’re unsure about using NSAIDs or need personalised guidance, you can consult a doctor online or book a lab test through Apollo 24|7 for a safe and convenient healthcare experience.

Conclusion

NSAIDs are helpful for short-term pain and inflammation, but they should be used wisely. Always follow dosage instructions, be aware of side effects, and consider natural alternatives when possible. If in doubt, your doctor can help you choose the safest option for your health.

Consult Top Specialists

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

450

No Booking Fees

Dr. Anand Ravi, General Physician

Dr. Anand Ravi

General Physician

2 Years • MBBS

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

400

Dr Syed Mateen Pasha, General Physician

Dr Syed Mateen Pasha

General Physician

2 Years • MBBS

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

400

Dr. D Bhanu Prakash, General Practitioner

Dr. D Bhanu Prakash

General Practitioner

10 Years • MBBS, AFIH, Advanced certificate in critical care medicine, Fellowship in critical care medicine

Hyderabad

Apollo 24|7 Clinic, Hyderabad

690

Dr. Sandhya Chandel, General Physician/ Internal Medicine Specialist

Dr. Sandhya Chandel

General Physician/ Internal Medicine Specialist

16 Years • MBBS, MD (Int. Med.), IDCCM

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

94%

(125+ Patients)

700

700

No Booking Fees

 

Consult Top Specialists

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

450

No Booking Fees

Dr. Anand Ravi, General Physician

Dr. Anand Ravi

General Physician

2 Years • MBBS

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

400

Dr Syed Mateen Pasha, General Physician

Dr Syed Mateen Pasha

General Physician

2 Years • MBBS

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

400

Dr. D Bhanu Prakash, General Practitioner

Dr. D Bhanu Prakash

General Practitioner

10 Years • MBBS, AFIH, Advanced certificate in critical care medicine, Fellowship in critical care medicine

Hyderabad

Apollo 24|7 Clinic, Hyderabad

690

Dr. Sandhya Chandel, General Physician/ Internal Medicine Specialist

Dr. Sandhya Chandel

General Physician/ Internal Medicine Specialist

16 Years • MBBS, MD (Int. Med.), IDCCM

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

94%

(125+ Patients)

700

700

No Booking Fees

Consult Top Specialists

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

450

No Booking Fees

Dr. Anand Ravi, General Physician

Dr. Anand Ravi

General Physician

2 Years • MBBS

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

400

Dr Syed Mateen Pasha, General Physician

Dr Syed Mateen Pasha

General Physician

2 Years • MBBS

Bengaluru

PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru

400

Dr. D Bhanu Prakash, General Practitioner

Dr. D Bhanu Prakash

General Practitioner

10 Years • MBBS, AFIH, Advanced certificate in critical care medicine, Fellowship in critical care medicine

Hyderabad

Apollo 24|7 Clinic, Hyderabad

690

Dr. Sandhya Chandel, General Physician/ Internal Medicine Specialist

Dr. Sandhya Chandel

General Physician/ Internal Medicine Specialist

16 Years • MBBS, MD (Int. Med.), IDCCM

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

94%

(125+ Patients)

700

700

No Booking Fees

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