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Kidney Cancer: Signs and Diagnosis

Learn about kidney cancer, including its early signs, symptoms, and diagnostic methods to ensure timely detection and effective treatment.

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Written by Dr. Dhankecha Mayank Dineshbhai

Reviewed by Dr. Shaik Abdul Kalam MD (Physician)

Last updated on 15th Sep, 2025

Introduction

Noticing something unusual with your health can be worrying, especially when it involves a vital organ like your kidneys. Kidney cancer, often silent in its early stages, can present with subtle signs that are easy to dismiss. This guide will walk you through the potential symptoms of kidney cancer and demystify the diagnostic process. Understanding these signs is the first step toward proactive health management. We'll cover everything from the well-known indicators to the less obvious systemic signals your body might send. More importantly, we'll clarify when it's crucial to seek professional medical advice. If you experience persistent symptoms like blood in your urine or unexplained pain, consulting a doctor online with Apollo24|7 for an initial evaluation can provide timely guidance and peace of mind.

Understanding Kidney Cancer: A Brief Overview

Gaining a clear understanding of kidney cancer is the first step toward early detection and effective treatment.

What are the Kidneys and What Do They Do?

Your two kidneys are bean-shaped organs, each about the size of a fist, located behind your abdominal organs on either side of your spine. They are your body's master filtration system, removing waste products and excess fluids from the blood to form urine. They also play a critical role in regulating blood pressure, producing red blood cells, and maintaining mineral balance.

Types of Kidney Cancer

While several types of cancer can affect the kidney, the most common by far is renal cell carcinoma (RCC), accounting for about 90% of cases. RCC begins in the lining of the kidney's tubules. Other, rarer types include transitional cell carcinoma (which starts in the renal pelvis), Wilms' tumour (a childhood kidney cancer), and renal sarcoma.

Consult a Urologist for the best advice

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Dr. Kunal Kumar Mehar

Urologist

10 Years • Mbbs, Ms, Mch

Bengaluru

Apollo Medical Center, Marathahalli, Bengaluru

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No Booking Fees

Dr. Vivekanand Hiremath, Urologist

Dr. Vivekanand Hiremath

Urologist

13 Years • MBBS. M S(General Surgery), M ch urology

Bengaluru

Apollo Clinic, Sarjapur Road, Bengaluru

recommendation

93%

(25+ Patients)

700

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No Booking Fees

Dr. Mohammed Rehan Khan, Urologist

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Early Signs and Symptoms of Kidney Cancer

Early-stage kidney cancer is often called a "silent disease" because it frequently causes no obvious signs. Many tumours are found incidentally during imaging tests for other issues, like abdominal pain or trauma. However, as the tumour grows, symptoms can develop.

The "Classic Triad" of Symptoms

The three classic signs of kidney cancer are haematuria, flank pain, and a palpable mass. However, it's rare for all three to appear simultaneously, especially in early-stage disease.

Haematuria (Blood in the Urine)

This is one of the most common symptoms of kidney tumour. The blood may be visible, turning the urine pink, red, or cola-colored (gross haematuria), or it may be microscopic, only detectable through a lab test. It's important to note that blood in the urine can come and go, which might lead someone to delay seeing a doctor. It is never a symptom to ignore.

Flank Pain

A persistent dull ache or a sharp pain in the side or lower back, below the ribs, can be a sign. This kidney cancer back pain is typically on one side and doesn't go away with changes in position or rest.

A palpable Abdominal Mass

In some cases, a lump or mass can be felt in the side or abdomen. However, due to the kidney's deep location, this is often a sign of a larger tumour and may not be detectable until the cancer is more advanced.

Paraneoplastic Syndromes: The Body's Indirect Signals

Kidney cancer is unique in that it can cause paraneoplastic syndromes, symptoms not caused by the tumour itself but by hormones or other substances the cancer cells produce. These can include:

  • High blood pressure (hypertension)

  • Night sweats

  • Fever

  • Unexplained weight loss

  • Loss of appetite

  • High calcium levels in the blood (hypercalcaemia), which can cause nausea, vomiting, and confusion.

Non-Specific General Symptoms

Many people experience general fatigue, a feeling of poor health, and persistent anaemia (low red blood cell count), which can cause tiredness and shortness of breath.

When to See a Doctor: Connecting Symptoms to Action

You should consult a doctor if you experience any persistent symptoms, especially:

  • Visible blood in your urine, even if it's just once.

  • Persistent pain in your back or side that doesn't seem related to an injury.

  • Unintentional weight loss.

  • Extreme fatigue that doesn't improve with rest.

If symptoms like blood in urine persist beyond a day or are recurrent, it is essential to seek a professional opinion. You can consult a doctor online with Apollo24|7 to discuss your symptoms and determine if further in-person investigation is needed.

How is Kidney Cancer Diagnosed? A Step-by-Step Guide

The kidney cancer diagnosis process involves several steps to confirm the presence of a tumour, identify its type, and determine its stage.

Initial Consultation and Physical Examination

Your doctor will discuss your medical history, risk factors, and symptoms. A physical exam may be conducted to check for a mass, swelling, or other signs, though small tumours are rarely felt.

Imaging Tests: The Eyes Inside Your Body

Imaging is the cornerstone of diagnosing a renal mass.

Computed Tomography (CT) Scan

This is the most important test for identifying and characterising a kidney tumour. A CT scan with contrast dye can show the size, shape, and location of a tumour and reveal if it has spread to nearby lymph nodes or organs. It's highly accurate for confirming the presence of a mass that is likely cancer.

Magnetic Resonance Imaging (MRI)

An MRI may be used if a patient cannot have a CT contrast dye (due to allergy or kidney issues) or to get a more detailed look at blood vessels around the tumour. It is particularly useful for examining blood flow and clarifying complex cases.

Ultrasound

This test uses sound waves to create images of the kidneys. It can help determine if a mass is a fluid-filled cyst (usually benign) or a solid tumour (which could be cancerous). It's often a first-line imaging test.

Biopsy: Confirming the Diagnosis

In a biopsy, a thin needle is guided into the tumour (often using CT or ultrasound imaging) to remove a small sample of tissue. A pathologist then examines the cells under a microscope to confirm the diagnosis of renal cell carcinoma and determine its grade (how aggressive the cells look). While not always needed before surgery, biopsies are crucial for planning treatment, especially for smaller tumours.

Additional Tests: Staging and Spread

Once cancer is confirmed, further tests like chest X-rays, bone scans, or additional CT scans may be done to see if the cancer has spread (metastasised), a process known as staging. Blood tests to check overall kidney function (creatinine, GFR) and overall health are also standard.

What Happens After Diagnosis? Understanding Staging

After c

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onfirmation, your cancer will be assigned a stage (I through IV) based on the TNM system:

  • T (tumour): Size and extent of the main tumour.

  • N (Node): Whether it has spread to nearby lymph nodes.

  • M (Metastasis): Whether it has spread to distant organs.

Staging is critical as it directly guides treatment decisions. Early-stage (I and II) cancers are confined to the kidney and have a very high cure rate with surgery. Apollo24|7 offers convenient home collection for tests like creatinine and other pre-operative blood work to help prepare for next steps.

Conclusion

Recognising the potential signs of kidney cancer is a powerful tool for your health. While symptoms like blood in the urine, flank pain, and unexplained weight loss are red flags, remember that early-stage disease often has none. This underscores the importance of paying attention to your body and not dismissing persistent changes. The diagnosis process, involving advanced imaging and sometimes a biopsy, is highly effective at identifying and characterising kidney cancer. If caught early, kidney cancer is often treatable and potentially curable. The most important takeaway is to act promptly. If you have any concerns or experience any of the symptoms discussed, don't hesitate to seek medical advice. Early detection and a clear understanding of your diagnosis are the first steps toward effective treatment and a positive outcome.

Consult a Urologist for the best advice

Dr. Kunal Kumar Mehar, Urologist

Dr. Kunal Kumar Mehar

Urologist

10 Years • Mbbs, Ms, Mch

Bengaluru

Apollo Medical Center, Marathahalli, Bengaluru

1000

1200

No Booking Fees

Dr. Vivekanand Hiremath, Urologist

Dr. Vivekanand Hiremath

Urologist

13 Years • MBBS. M S(General Surgery), M ch urology

Bengaluru

Apollo Clinic, Sarjapur Road, Bengaluru

recommendation

93%

(25+ Patients)

700

1000

No Booking Fees

Dr. Mohammed Rehan Khan, Urologist

Dr. Mohammed Rehan Khan

Urologist

8 Years • MBBS, MS (General Surgery), Mch (Urology)

Barasat

Diab-Eat-Ease, Barasat

700

Consult a Urologist for the best advice

Dr Karthik Maripeddi, Urologist

Dr Karthik Maripeddi

Urologist

13 Years • MBBS MS FMAS MCh URO(OSM)

Hyderguda

Apollo Hospitals Hyderguda, Hyderguda

1000

No Booking Fees

Dr. Kunal Kumar Mehar, Urologist

Dr. Kunal Kumar Mehar

Urologist

10 Years • Mbbs, Ms, Mch

Bengaluru

Apollo Medical Center, Marathahalli, Bengaluru

1000

1200

No Booking Fees

Dr. Pavan Kumar S K, Urologist

Dr. Pavan Kumar S K

Urologist

11 Years • MBBS, MS , Mch( Urology) DNB (Urology)

Bengaluru

Apollo Clinic, JP nagar, Bengaluru

1000

Dr. Vivekanand Hiremath, Urologist

Dr. Vivekanand Hiremath

Urologist

13 Years • MBBS. M S(General Surgery), M ch urology

Bengaluru

Apollo Clinic, Sarjapur Road, Bengaluru

recommendation

93%

(25+ Patients)

700

1000

No Booking Fees

Dr. Mohammed Rehan Khan, Urologist

Dr. Mohammed Rehan Khan

Urologist

8 Years • MBBS, MS (General Surgery), Mch (Urology)

Barasat

Diab-Eat-Ease, Barasat

700

Get Your Health Assessed

259(₹648)60% off

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