Myasthenia Gravis Overview and Treatment Options
Myasthenia Gravis (MG) is a rare autoimmune disorder that causes muscle weakness and fatigue. Learn about its symptoms, causes, diagnosis, treatment options, and lifestyle tips for better management.
Written by Dr. Rohinipriyanka Pondugula
Reviewed by Dr. D Bhanu Prakash MBBS, AFIH, Advanced certificate in critical care medicine, Fellowship in critical care medicine
Last updated on 3rd Sep, 2025
Living with a chronic condition can be challenging, but understanding it better can help you manage it effectively. Myasthenia Gravis (MG) is one such condition that affects muscle strength and movement. If you or a loved one has been diagnosed with MG, this article will help you understand the condition, its symptoms, causes, and available treatment options.
What is Myasthenia Gravis?
Myasthenia Gravis is a rare autoimmune disorder that weakens the muscles, making them tire easily with activity. The name itself means "grave muscle weakness," but with proper treatment, most people with MG can lead active lives.
In MG, the immune system mistakenly attacks the communication points between nerves and muscles (called neuromuscular junctions). This disrupts signals from the brain to the muscles, leading to muscle weakness that worsens with use and improves with rest.
Symptoms of Myasthenia Gravis
The symptoms of MG vary from person to person but often include:
Drooping eyelids (ptosis) – One or both eyelids may sag.
Double vision (diplopia) – Due to weakened eye muscles.
Difficulty speaking or swallowing – Speech may become slurred, and swallowing may be hard.
Weakness in arms, legs, or neck – Makes it hard to lift objects, walk, or hold up the head.
Shortness of breath – In severe cases, chest muscles weaken, affecting breathing.
Symptoms tend to worsen with activity and improve after rest. They may also fluctuate throughout the day.
Causes and Risk Factors
MG occurs when the immune system produces antibodies that block or destroy acetylcholine receptors (needed for muscle contraction). While the exact cause is unknown, certain factors increase the risk:
Thymus gland abnormalities – Many MG patients have an enlarged thymus gland or thymoma (a tumor).
Autoimmune conditions – Other autoimmune disorders (like rheumatoid arthritis or lupus) may increase risk.
Age and gender – Women under 40 and men over 60 are more commonly affected.
How is Myasthenia Gravis Diagnosed?
If you experience muscle weakness that improves with rest, your doctor may recommend:
1. Blood tests – To check for acetylcholine receptor antibodies.
2. Electromyography (EMG) – Measures electrical activity in muscles.
3. Edrophonium (Tensilon) test – A medication temporarily improves muscle strength in MG patients.
4. Imaging tests (CT/MRI) – To check for thymus abnormalities.
Early diagnosis helps in managing symptoms effectively.
Treatment Options for Myasthenia Gravis
While there’s no cure for MG, treatments can help control symptoms and improve quality of life. Options include:
1. Medications
Cholinesterase inhibitors (e.g., Pyridostigmine) – Help improve nerve-muscle communication.
Immunosuppressants (e.g., Prednisone, Azathioprine) – Reduce abnormal immune responses.
Monoclonal antibodies (e.g., Rituximab, Eculizumab) – Target specific immune cells.
2. Thymectomy (Surgery)
Removing the thymus gland can improve symptoms, especially in patients with thymoma.
3. Plasma Exchange (Plasmapheresis)
Removes harmful antibodies from the blood, providing short-term relief.
4. Intravenous Immunoglobulin (IVIG)
Boosts healthy antibodies to suppress the immune attack.
Lifestyle Tips for Managing Myasthenia Gravis
Along with medical treatment, these lifestyle changes can help:
Conserve energy – Take frequent breaks to avoid muscle fatigue.
Eat soft foods – If swallowing is difficult, opt for easy-to-chew meals.
Avoid stress and infections – They can worsen symptoms.
Exercise gently – Light activities like walking or yoga help maintain strength.
Follow doctor’s advice – Take medications on time and attend follow-ups.
When to Seek Emergency Help?
A myasthenic crisis (severe muscle weakness affecting breathing) is a medical emergency. If you experience:
Severe breathing difficulty
Extreme trouble swallowing
Sudden worsening of weakness
Seek immediate medical attention.
Living Well with Myasthenia Gravis
With proper treatment and self-care, most MG patients can lead fulfilling lives. If you suspect symptoms, consult a neurologist for early diagnosis and management.
Need Expert Advice?
If you or someone you know is experiencing muscle weakness, Apollo 24|7 offers consultations with experienced neurologists. You can book an appointment or schedule tests easily through the Apollo 24|7 app or website.
Consult a Specialist for Personalised Advice
Consult a Specialist for Personalised Advice
Dr. Mohamed Azeem
General Physician/ Internal Medicine Specialist
2 Years • MBBS,MD(Internal Medicine) CCEBDM
Karaikudi
Apollo Hospitals Karaikudi, Karaikudi
Dr. Sandhya Chandel
General Physician/ Internal Medicine Specialist
16 Years • MBBS, MD (Int. Med.), IDCCM
Bilaspur
Apollo Hospitals Seepat Road, Bilaspur
(125+ Patients)
Dr Aakash Andgi
General Physician/ Internal Medicine Specialist
9 Years • MBBS MD
Bengaluru
Apollo Clinic, JP nagar, Bengaluru
Dr Syed Mateen Pasha
General Physician
2 Years • MBBS
Bengaluru
PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru
Dr. Anand Ravi
General Physician
2 Years • MBBS
Bengaluru
PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru
