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Your Essential Guide to Restless Legs Syndrome

Discover everything you need to know about Restless Legs Syndrome (RLS) – causes, symptoms, diagnosis, treatments, and practical coping strategies for better sleep and relief.

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Written by Dr. D Bhanu Prakash

Reviewed by Dr. Siri Nallapu MBBS

Last updated on 12th Sep, 2025

Your Essential Guide to Restless Legs Syndrome

Introduction

That uncontrollable urge to move your legs, especially at night when you're trying to relax. A creeping, crawling, or throbbing sensation that only subsides with movement. If this sounds familiar, you might be experiencing Restless Legs Syndrome (RLS), a common but often misunderstood neurological condition. Far from being a simple case of "fidgeting," RLS can severely disrupt sleep, impact daily life, and cause significant distress. This guide is designed to answer all your burning questions about syndrome FAQs restless legs. We'll delve into the causes, symptoms, and most importantly, the practical strategies and treatments that can help you reclaim peaceful nights and calm legs. Whether you're seeking answers for yourself or a loved one, consider this your comprehensive resource for understanding and managing RLS.

What Exactly is Restless Legs Syndrome (RLS)?

Restless Legs Syndrome (RLS), also known as Willis-Ekbom Disease, is a sensorimotor neurological disorder characterised by an overwhelming and often irresistible urge to move the legs. It’s not just a feeling of restlessness; it’s a specific medical condition with defined diagnostic criteria. The sensations are typically worse during periods of inactivity and in the evening or night, creating a cruel paradox where the time you need to be most still is when your body protests the most. The relief upon movement is usually immediate but, frustratingly, often temporary. Understanding that RLS is a legitimate medical issue, not a psychological one, is the first step toward effective management.

The Core Symptoms: More Than Just an Urge to Move

The hallmark symptoms of restless legs syndrome are universally recognised by those who have it:

  • An Urge to Move: The primary symptom is a compelling need to move the legs, often accompanied by uncomfortable sensations.
  • Unpleasant Sensations: People describe these feelings as crawling, creeping, pulling, itching, throbbing, aching, or electric. It's important to note that some individuals have the urge to move without the obvious sensations.
  • Worsening at Rest: Symptoms begin or intensify when sitting or lying down for an extended period, like watching a film or flying on a plane.
  • Relief with Movement: Walking, stretching, jiggling the legs, or simply shifting position provides partial or total relief while the activity continues.
  • Evening Worsening: A clear circadian pattern exists where symptoms are significantly more pronounced in the evening and night.

Who is at Risk? Understanding RLS Demographics

RLS does not discriminate, but it does have preferences. It affects both sexes but is more common in women. While it can begin at any age, RLS and age are linked, with severity often increasing with older age. However, many adults diagnosed later in life recall symptoms dating back to childhood, often mislabelled as "growing pains." There is also a strong genetic component; approximately half of those with RLS have a family history of the condition.

Unravelling the Causes: Why Do People Get RLS?

The exact cause of RLS is still a subject of research, but it's closely linked to how the brain uses dopamine, a neurotransmitter involved in controlling muscle movement. Experts categorise RLS into two types.

Consult an Neurologist doctor for the best advice

Dr. H Rahul, Neurologist

Dr. H Rahul

Neurologist

10 Years • MBBS, MD(Gen. Med.), DM(Neuro)

Secunderabad

Apollo Hospitals Secunderabad, Secunderabad

recommendation

98%

(100+ Patients)

900

No Booking Fees

Dr. Prabash P R, Neurologist

Dr. Prabash P R

Neurologist

16 Years • MBBS, MD, DM

Chennai

Apollo Speciality Hospitals Vanagaram, Chennai

recommendation

89%

(75+ Patients)

1000

No Booking Fees

Dr. Satish Bawri, Neurologist

Dr. Satish Bawri

Neurologist

7 Years • MBBS:MD(Med.);DM(Neuro)

Guwahati

Apollo Hospitals G S Road, Guwahati

recommendation

85%

(75+ Patients)

800

No Booking Fees

Dr. Mutiki Ramesh Babu	, Neurologist

Dr. Mutiki Ramesh Babu

Neurologist

7 Years • MD, DNB

Visakhapatnam

Apollo Hospital Visakhapatanam, Visakhapatnam

recommendation

93%

(100+ Patients)

700

600

No Booking Fees

Primary RLS: The Genetic Link

Primary RLS is idiopathic, meaning it has no known underlying cause. It is often familial, with symptoms starting before age 40 and gradually worsening over time. Research has identified specific gene variants associated with an increased risk of developing this form of RLS.

Secondary RLS: Underlying Conditions and Triggers

Secondary RLS is caused by another medical condition or factor. Addressing the root cause can often alleviate the RLS symptoms. Common triggers include:

  • Iron Deficiency (Low Ferritin): This is one of the most significant and treatable causes.
  • End-Stage Renal Disease and Dialysis
  • Peripheral Neuropathy
  • Spinal Cord Conditions
  • Pregnancy (especially in the third trimester)
  • Certain Medications: Such as anti-nausea drugs, antipsychotics, and some antidepressants.

The Iron Connection: A Key Player in RLS

Brain iron deficiency is a central theory in RLS pathophysiology. Iron is a co-factor for tyrosine hydroxylase, a rate-limiting enzyme in dopamine production. Low iron stores in the brain, even if blood tests show borderline normal levels, can disrupt dopamine signalling and trigger RLS symptoms. This is why checking ferritin levels is a critical part of the diagnostic process.

Medications and Substances That Can Worsen RLS

Be aware that certain substances can exacerbate symptoms. These include caffeine, alcohol, and nicotine. Furthermore, as mentioned, some prescription medications, particularly sedating antihistamines (found in many cold and sleep aids) and antidepressants, can trigger or worsen RLS. If your symptoms began after starting a new medication, discuss this with your doctor.

How is Restless Legs Syndrome Diagnosed?

There is no single test for RLS. Diagnosis is primarily clinical, based on your reported symptoms and medical history.

The Essential Diagnostic Criteria

A doctor will use five essential criteria for diagnosis:

  1. An urge to move the legs, usually with uncomfortable sensations.
  2. The urge begins or worsens during periods of rest or inactivity.
  3. The urge is partially or totally relieved by movement.
  4. The urge is worse in the evening or night than during the day.
  5. These features are not solely accounted for by another medical or behavioural condition.

Tests Your Doctor Might Recommend

While there's no confirmatory test, doctors use tests to rule out other conditions and check for secondary causes. This includes:

  • Blood Tests: Specifically to check ferritin levels (a measure of iron stores). Apollo24|7 offers convenient home collection for tests like ferritin, vitamin D, or HbA1c, making it easier to check these levels without a clinic visit.
  • Neurological Exam: To rule out peripheral neuropathy.
  • Sleep Study (Polysomnography): This is not for diagnosing RLS itself but to check for Periodic Limb Movement Disorder (PLMD), which occurs in about 80% of people with RLS and can further disrupt sleep.

Effective Strategies for Managing and Treating RLS

Treatment is highly personalised, focusing on relieving symptoms and addressing any underlying causes.

Lifestyle Changes and Home Remedies for Immediate Relief

For mild RLS, home remedies for RLS can be remarkably effective:

  • Regular, Moderate Exercise: Daily activity like walking or swimming helps, but avoid intense workouts close to bedtime.
  • Leg Massages and Stretching: Regular calf and hamstring stretches can pre-emptively calm symptoms.
  • Heat and Cold Therapy: A warm bath or a cold compress applied to the legs can alter sensations and provide relief.
  • Establish a Sleep Routine: A cool, dark, and quiet bedroom and a consistent sleep schedule are crucial.
  • Mind Caffeine and Alcohol: Try eliminating them, especially in the afternoon and evening, to see if symptoms improve.

Medical Treatments: From Iron Supplements to Prescription Drugs

If lifestyle changes aren't enough, medical options are available:

  1. Iron Supplementation: If tests show low ferritin levels, your doctor will recommend iron supplements.
  2. Prescription Medications:
  • Dopaminergic Agents (e.g., Pramipexole, Ropinirole): These are often first-line treatments but can cause "augmentation" (symptoms worsening over time).
  • Alpha-2-delta Ligands (e.g., Gabapentin, Pregabalin): These are now commonly preferred as first-line as they are effective and have a lower risk of augmentation.
  • Benzodiazepines: Used sparingly for sleep but not for primary RLS symptoms due to risk of dependency.
  • Opioids: Reserved for severe, refractory cases due to their addiction potential.

If your condition does not improve after trying these methods, book a physical visit to a doctor with Apollo24|7 for further evaluation and to discuss these prescription options.

Living with RLS: Long-Term Outlook and Coping Mechanisms

RLS is often a lifelong condition, but it doesn't have to control your life. Symptoms may wax and wane, and periods of remission are possible.

The Impact of RLS on Sleep and Mental Health

The chronic sleep deprivation caused by RLS can lead to daytime fatigue, difficulty concentrating, mood swings, anxiety, and depression. Acknowledging this impact is vital. Treating the RLS often improves sleep, which in turn boosts mental well-being.

Tips for Travelling and Sitting for Long Periods

This is a major challenge for those with RLS. Plan ahead:

  • Choose an aisle seat on planes or in theatres to allow for easy movement.
  • Schedule breaks on road trips to get out and stretch.
  • Perform seated exercises like ankle rotations and leg extensions.
  • Stay hydrated and avoid caffeine during the journey.

Conclusion

Living with Restless Legs Syndrome can feel like a lonely and frustrating battle, especially during the quiet of the night. However, as this guide has shown, RLS is a recognised medical condition with a clear set of symptoms, known triggers, and a growing number of effective management strategies. From understanding the crucial role of iron to implementing simple home remedies for RLS and knowing when to seek medical help, you are now equipped with knowledge. Remember, you don't have to just "live with it." Taking proactive steps, tracking your symptoms, and partnering with a knowledgeable healthcare provider are the keys to breaking the cycle of restless nights. If symptoms persist beyond two weeks, consult a doctor online with Apollo24|7 for further evaluation and to create a personalised plan that brings you the calm and rest you deserve.

Consult an Neurologist doctor for the best advice

Dr. H Rahul, Neurologist

Dr. H Rahul

Neurologist

10 Years • MBBS, MD(Gen. Med.), DM(Neuro)

Secunderabad

Apollo Hospitals Secunderabad, Secunderabad

recommendation

98%

(100+ Patients)

900

No Booking Fees

Dr. Prabash P R, Neurologist

Dr. Prabash P R

Neurologist

16 Years • MBBS, MD, DM

Chennai

Apollo Speciality Hospitals Vanagaram, Chennai

recommendation

89%

(75+ Patients)

1000

No Booking Fees

Dr. Satish Bawri, Neurologist

Dr. Satish Bawri

Neurologist

7 Years • MBBS:MD(Med.);DM(Neuro)

Guwahati

Apollo Hospitals G S Road, Guwahati

recommendation

85%

(75+ Patients)

800

No Booking Fees

Dr. Mutiki Ramesh Babu	, Neurologist

Dr. Mutiki Ramesh Babu

Neurologist

7 Years • MD, DNB

Visakhapatnam

Apollo Hospital Visakhapatanam, Visakhapatnam

recommendation

93%

(100+ Patients)

700

600

No Booking Fees

Consult an Neurologist doctor for the best advice

Dr. H Rahul, Neurologist

Dr. H Rahul

Neurologist

10 Years • MBBS, MD(Gen. Med.), DM(Neuro)

Secunderabad

Apollo Hospitals Secunderabad, Secunderabad

recommendation

98%

(100+ Patients)

900

No Booking Fees

Dr. J C Rasmi Reddy, Neurologist

Dr. J C Rasmi Reddy

Neurologist

5 Years • M.B.B.S, M.D, DrNb in Neurology

Nellore

Apollo Speciality Hospitals, Nellore

600

600

No Booking Fees

Dr. Prabash P R, Neurologist

Dr. Prabash P R

Neurologist

16 Years • MBBS, MD, DM

Chennai

Apollo Speciality Hospitals Vanagaram, Chennai

recommendation

89%

(75+ Patients)

1000

No Booking Fees

Dr. Satish Bawri, Neurologist

Dr. Satish Bawri

Neurologist

7 Years • MBBS:MD(Med.);DM(Neuro)

Guwahati

Apollo Hospitals G S Road, Guwahati

recommendation

85%

(75+ Patients)

800

No Booking Fees

Dr. Mutiki Ramesh Babu	, Neurologist

Dr. Mutiki Ramesh Babu

Neurologist

7 Years • MD, DNB

Visakhapatnam

Apollo Hospital Visakhapatanam, Visakhapatnam

recommendation

93%

(100+ Patients)

700

600

No Booking Fees

Consult an Neurologist doctor for the best advice

Dr. H Rahul, Neurologist

Dr. H Rahul

Neurologist

10 Years • MBBS, MD(Gen. Med.), DM(Neuro)

Secunderabad

Apollo Hospitals Secunderabad, Secunderabad

recommendation

98%

(100+ Patients)

900

No Booking Fees

Dr. J C Rasmi Reddy, Neurologist

Dr. J C Rasmi Reddy

Neurologist

5 Years • M.B.B.S, M.D, DrNb in Neurology

Nellore

Apollo Speciality Hospitals, Nellore

600

600

No Booking Fees

Dr. Prabash P R, Neurologist

Dr. Prabash P R

Neurologist

16 Years • MBBS, MD, DM

Chennai

Apollo Speciality Hospitals Vanagaram, Chennai

recommendation

89%

(75+ Patients)

1000

No Booking Fees

Dr. Satish Bawri, Neurologist

Dr. Satish Bawri

Neurologist

7 Years • MBBS:MD(Med.);DM(Neuro)

Guwahati

Apollo Hospitals G S Road, Guwahati

recommendation

85%

(75+ Patients)

800

No Booking Fees

Dr. Mutiki Ramesh Babu	, Neurologist

Dr. Mutiki Ramesh Babu

Neurologist

7 Years • MD, DNB

Visakhapatnam

Apollo Hospital Visakhapatanam, Visakhapatnam

recommendation

93%

(100+ Patients)

700

600

No Booking Fees

Frequently Asked Questions

Can restless legs syndrome be cured?

There is no definitive cure for primary (genetic) RLS. However, symptoms can be managed very effectively with lifestyle changes and medication. Secondary RLS often improves significantly or resolves completely once the underlying cause (like iron deficiency) is treated.

What is the difference between RLS and periodic limb movement disorder (PLMD)?

RLS occurs while you are awake and involves conscious, voluntary movement to relieve discomfort. PLMD occurs during sleep and involves involuntary, rhythmic jerking of the legs every 20-40 seconds. While they are related and often co-exist, they are distinct conditions.

Are there any new treatments for RLS on the horizon?

Yes, research is ongoing. Recent advancements include a deeper understanding of the role of iron in the brain and the development of newer alpha-2-delta ligands (like gabapentin enacarbil) which are proving to be effective first-line treatments with fewer side effects than traditional dopaminergic drugs.

Does RLS only affect the legs?

Primarily, yes. However, in more severe cases, the uncomfortable sensations and urge to move can also affect the arms, torso, or even phantom limbs in amputees.

I'm pregnant and my RLS is worse. Is this normal?

Yes, RLS during pregnancy is very common, especially in the third trimester. It's often linked to folate or iron deficiency. Symptoms usually resolve within a few weeks after delivery. Always discuss management options with your obstetrician to ensure they are safe for pregnancy.