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Causes of Vaginal Cancer Explained

Gain a clear understanding of the causes of vaginal cancer, including the strong link to HPV infection, age, and other risk factors. Learn about prevention strategies and the importance of early detection for this rare gynecological cancer.

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Written by Dr. Mohammed Kamran

Reviewed by Dr. M L Ezhilarasan MBBS

Last updated on 19th Aug, 2025

Vaginal Cancer

Vaginal cancer is a rare but serious condition that affects women, usually later in life. Understanding its causes can help in early detection and prevention. If you or someone you know is concerned about vaginal cancer, this article will explain the possible causes, risk factors, and ways to reduce your risk.

What Is Vaginal Cancer?

Vaginal cancer occurs when abnormal cells grow uncontrollably in the vagina, the muscular tube connecting the uterus to the outer genitals. While it is uncommon, knowing the causes can help in early diagnosis and better treatment outcomes.

Main Causes of Vaginal Cancer

The exact cause of vaginal cancer is not always clear, but certain factors increase the risk. Here are the most common causes and risk factors:

1. Human Papillomavirus (HPV) Infection

HPV is the most significant risk factor for vaginal cancer. This sexually transmitted virus can cause changes in vaginal cells, leading to cancer over time. Getting vaccinated against HPV and regular screenings (like Pap smears) can help prevent it.

2. Age

Vaginal cancer is more common in women over 60. As women age, their risk increases, especially if other risk factors are present.

3. History of Cervical Cancer or Precancerous Conditions

Women who have had cervical cancer or precancerous changes in the cervix (like cervical dysplasia) are at higher risk of developing vaginal cancer. This may be due to shared risk factors like HPV.

4. Smoking

Smoking weakens the immune system and increases the risk of HPVrelated cancers, including vaginal cancer. Quitting smoking can significantly lower this risk.

5. Exposure to Diethylstilbestrol (DES) in the Womb

DES was a drug given to some pregnant women between 1940 and 1971 to prevent miscarriages. Women whose mothers took DES have a higher risk of a rare type of vaginal cancer called clear cell adenocarcinoma.

6. Weakened Immune System

Conditions like HIV/AIDS or medications that suppress immunity (such as after an organ transplant) can increase the risk of vaginal cancer.

7. Chronic Vaginal Irritation

Long-term irritation from vaginal pessaries (devices used for pelvic organ prolapse) or other factors may slightly increase the risk, though this is rare.

Consult Top Oncologist

Dr Sunita Samleti, Oncologist

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Apollo Hospitals Health City Unit, Chinagadila

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Dr. Gopal Kumar, Head, Neck and Thyroid Cancer Surgeon

Dr. Gopal Kumar

Head, Neck and Thyroid Cancer Surgeon

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Delhi

Apollo Hospitals Indraprastha, Delhi

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How Does Vaginal Cancer Affect Health?

If left untreated, vaginal cancer can spread to nearby tissues like the bladder, rectum, or lymph nodes. Early symptoms may include:

  • Unusual vaginal bleeding (after menopause or between periods)
  • Watery or foul-smelling vaginal discharge
  • Pain during sex
  • Pelvic pain or a lump in the vagina
  • Frequent urination or pain while urinating

If you experience any of these symptoms, consult a doctor for evaluation.

How Can You Reduce Your Risk?

While not all cases can be prevented, you can lower your risk by:

  • Getting the HPV vaccine (recommended for girls and boys aged 9–26)
  • Regular Pap smears and pelvic exams to detect early changes
  • Quitting smoking to improve immune function
  • Practicing safe sex to reduce HPV exposure
  • Maintaining good vaginal hygiene without harsh chemicals

When to See a Doctor?

If you notice unusual symptoms like abnormal bleeding, persistent pain, or unusual discharge, do not ignore them. Early detection improves treatment success.

Need Help? Book a Consultation Today

If you have concerns about vaginal cancer or need screening, Apollo 24|7 offers expert consultations and diagnostic tests. You can easily book an appointment online for personalized care.

Final Thoughts

Vaginal cancer is rare but understanding its causes helps in prevention and early detection. By managing risk factors like HPV, smoking, and regular checkups, you can take proactive steps toward better health. Always consult a doctor if you notice any unusual symptoms—your health matters!

Would you like to schedule a screening or talk to a specialist? Visit Apollo 24|7 for trusted medical advice and care. Stay informed, stay healthy!

Consult Top Oncologist

Dr Sunita Samleti, Oncologist

Dr Sunita Samleti

Oncologist

18 Years • M.D. (Pathology)- TN Medical College, Mumbai University, Mumbai, Mar 2005 M.B.B.S. Grant Medical College, Mumbai University, Mumbai, Oct 1999

Chinagadila

Apollo Hospitals Health City Unit, Chinagadila

600

60 Cashback

600

Dr Gowshikk Rajkumar, Oncologist

Dr Gowshikk Rajkumar

Oncologist

10 Years • MBBS, DMRT, DNB in Radiation oncology

Bengaluru

Apollo Clinic, JP nagar, Bengaluru

900

135 Cashback

900

No Booking Fees

Dr. Gopal Kumar, Head, Neck and Thyroid Cancer Surgeon

Dr. Gopal Kumar

Head, Neck and Thyroid Cancer Surgeon

15 Years • MBBS, MS , FARHNS ( Seoul, South Korea ), FGOLF ( MSKCC, New York )

Delhi

Apollo Hospitals Indraprastha, Delhi

recommendation

89%

(25+ Patients)

1500

150 Cashback

2000

No Booking Fees

Consult Top Oncologist

Dr Sunita Samleti, Oncologist

Dr Sunita Samleti

Oncologist

18 Years • M.D. (Pathology)- TN Medical College, Mumbai University, Mumbai, Mar 2005 M.B.B.S. Grant Medical College, Mumbai University, Mumbai, Oct 1999

Chinagadila

Apollo Hospitals Health City Unit, Chinagadila

600

60 Cashback

600

Dr.sanchayan Mandal, Oncologist

Dr.sanchayan Mandal

Oncologist

17 Years • MBBS, DrNB( MEDICAL ONCOLOGY), DNB (RADIOTHERAPY),ECMO. PDCR. ASCO

Kolkata

Dr. Sanchayan Mandal Oncology Clinic, Kolkata

1500

1500

No Booking Fees

Dr. Sanchayan Mandal, Oncologist

Dr. Sanchayan Mandal

Oncologist

17 Years • MBBS, DNB Raditherapy, DrNB Medical Oncology

East Midnapore

VIVEKANANDA SEBA SADAN, East Midnapore

1500

Dr Gowshikk Rajkumar, Oncologist

Dr Gowshikk Rajkumar

Oncologist

10 Years • MBBS, DMRT, DNB in Radiation oncology

Bengaluru

Apollo Clinic, JP nagar, Bengaluru

900

135 Cashback

900

No Booking Fees

Dr. Gopal Kumar, Head, Neck and Thyroid Cancer Surgeon

Dr. Gopal Kumar

Head, Neck and Thyroid Cancer Surgeon

15 Years • MBBS, MS , FARHNS ( Seoul, South Korea ), FGOLF ( MSKCC, New York )

Delhi

Apollo Hospitals Indraprastha, Delhi

recommendation

89%

(25+ Patients)

1500

150 Cashback

2000

No Booking Fees

Consult Top Oncologist

Dr Sunita Samleti, Oncologist

Dr Sunita Samleti

Oncologist

18 Years • M.D. (Pathology)- TN Medical College, Mumbai University, Mumbai, Mar 2005 M.B.B.S. Grant Medical College, Mumbai University, Mumbai, Oct 1999

Chinagadila

Apollo Hospitals Health City Unit, Chinagadila

600

60 Cashback

600

Dr.sanchayan Mandal, Oncologist

Dr.sanchayan Mandal

Oncologist

17 Years • MBBS, DrNB( MEDICAL ONCOLOGY), DNB (RADIOTHERAPY),ECMO. PDCR. ASCO

Kolkata

Dr. Sanchayan Mandal Oncology Clinic, Kolkata

1500

1500

No Booking Fees

Dr. Sanchayan Mandal, Oncologist

Dr. Sanchayan Mandal

Oncologist

17 Years • MBBS, DNB Raditherapy, DrNB Medical Oncology

East Midnapore

VIVEKANANDA SEBA SADAN, East Midnapore

1500

Dr Gowshikk Rajkumar, Oncologist

Dr Gowshikk Rajkumar

Oncologist

10 Years • MBBS, DMRT, DNB in Radiation oncology

Bengaluru

Apollo Clinic, JP nagar, Bengaluru

900

135 Cashback

900

No Booking Fees

Dr. Gopal Kumar, Head, Neck and Thyroid Cancer Surgeon

Dr. Gopal Kumar

Head, Neck and Thyroid Cancer Surgeon

15 Years • MBBS, MS , FARHNS ( Seoul, South Korea ), FGOLF ( MSKCC, New York )

Delhi

Apollo Hospitals Indraprastha, Delhi

recommendation

89%

(25+ Patients)

1500

150 Cashback

2000

No Booking Fees

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