Can HBsAg positive become negative?

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Dr Kareemulla Shaik

General Practitioner

MBBS
0+ Yrs

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yes due to production of AntiHbsAg, and considered as resolved Hepatitis B although its very rare

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Answered 04/07/2025

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For your question about whether someone who is HBsAg positive can become negative, here are the key points to understand:

HBsAg (Hepatitis B surface antigen) positivity indicates the presence of the hepatitis B virus in the blood.
Immune Clearance: a. Many adults, especially those who acquire hepatitis B later in life, can clear the virus naturally. b. This process can take months to years, resulting in HBsAg becoming negative.
Chronic Hepatitis B: a. Some individuals may develop chronic hepatitis B, where HBsAg remains positive for more than 6 months. b. Regular monitoring by a healthcare provider is crucial to assess liver health and viral status.
Treatment: a. Options are available if the infection is chronic or causing liver damage.

Consult a healthcare professional for personalized advice and follow-up testing. They can guide you on prognosis, monitoring, and treatment if needed.

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