Insulin helps blood sugar enter the body's cells so it can be used for energy. Insulin also signals the liver to store blood sugar for later use.
If your cells become too resistant to insulin, it leads to elevated blood glucose levels (hyperglycemia), which, over time, leads to prediabetes and Type 2 diabetes.
Insulin is transcribed and expressed in the beta-cells of the pancreas, from whence it is exported through the portal circulation to the liver
In type 2 diabetes, the pancreas makes insulin, but the cells don't respond to it as they should. This is called insulin resistance. When glucose can't get into cells, the blood sugar level rises.