What are elevated hemoglobin and hemocrit?
Both the hemoglobin and the hematocrit are based on whole blood and are therefore dependent on plasma volume. If a patient is severely dehydrated, the hemoglobin and hematocrit will appear higher than if the patient had sufficient water. However, if the patient is fluid overloaded, they will be lower than their actual level.
Polycythemia vera result in sideroblastic anemia because the marrow can no longer produce blood cells resulting in low levels of healthy functioning red blood cells causing anemia, platelets (thrombocytopenia) and white blood cells (leukopenia).
When the red blood cell count reaches a critical number, the flowability of the blood decreases leading to restricted blood circulation. This causes a blue coloration of the skin (cyanosis).
Thrombocytopenia could be due to an increased platelet aggregation and adhesion caused by hyperviscosity. The marrow can no longer produces blood cells resulting in low levels of healthy, functioning red blood cells which causes anemia, platelets (thrombocytopenia) and white blood cells (leukopenia).
Research has shown that people with Polycythemia tend to have higher levels of mast cells in their blood. Mast cells are involved in the immune system's allergic response. They release histamines, which cause allergic symptoms, including itching skin