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    blood sample




    Age group

    Above 10 years

    Chronic lymphocytic leukaemia (CLL) is a white blood cancer with a slow progression. Since lymphocytes are responsible for fighting infections in a body, this condition significantly affects the body’s immunity. Despite having an abnormally high number of lymphocytes in your body, the system does not work properly.

    A chronic leukaemia test is necessary to detect the condition and make therapeutic interventions. 
    The lymphocyte development majorly occurs in the bone marrow. Also, most adults or middle-aged people are prone to this condition. One cannot rely on symptoms for CLL diagnosis because it has slow progression and remains asymptomatic for years.

    A CD23 marker test is a reliable diagnostic technique for CLL diagnosis that looks for a unique cell surface protein. This test differentiates between chronic lymphocytic leukaemia and other types of leukaemia.

    Apollo 24|7 offers a chronic leukaemia test for the suspected candidates to confirm their condition. While chronic leukaemia may not show severe symptoms, early diagnosis helps ease the symptoms and leaves a better scope for treatments.

    The essential CLL diagnosis depends on a CD23 test which forms the cluster of differentiation (CD). One can go for a CD23 marker test after observing the following symptoms in their bodies:

    • Swelling in the lymph node such as the neck, groin, armpit, or stomach 
    • Difficulty in breathing 
    • Feeling bloated and frequent stomach pain episodes
    • Enlargement of the spleen
    • Fatigue 
    • Night sweats
    • Frequent fever due to infections
    • Unexplained loss of weight and appetite

    The primary techniques used in the chronic leukaemia test include flow cytometry or western blotting. 
    Flow cytometry is a technique used to check for the properties of the cells. They are programmed to flow across a thin sheet-like fluid channel in this procedure. While flowing, the waves pass through them, and scattered rays are observed using optical devices.

    The kind of scattering determines several factors about the cell. These factors include cell size, structure, DNA content, intracellular proteins, gene expression, and transient signalling.

    On the other hand, the western blotting technique identifies a specific protein in the cell lysate using antibodies. Since the antibodies are particular, they bind to only a specific sequence of amino acids. 
    Further steps include separating the proteins using the SDS-PAGE technique, transferring the protein from the membrane, immunoblotting, and detecting the surface markers.

    Even though both the techniques are accurate, western blotting is more prone to manual errors because it is a lengthy technique. Additionally, it requires manual sample preparation and experiments that may not be entirely accurate.

    However, a flow cytometry technique depends mainly on the fluorescence marking of the surface antigen and detection using a computerised system. This makes the entire process reliable because the experiment has fewer manual interventions.

    Thus, to help your doctor analyse the CD23 test results accurately, you need to discuss the following things with them:

    • Frequency of infections
    • Changes in the immune system response
    • Respiratory function
    • Ongoing medications
    • Healing process after a recent minor or major injury
    • Pattern of weight loss

    Apart from this, you can also observe the pattern of lymph node swelling and other minor symptoms in your body to understand the intensity of your condition. 

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    CD23 marker test not only indicates the presence of a CLL but also helps diagnose mantle cell leukaemia. The latter is an aggressive form of the disease that may deteriorate the quality of a patient’s life. Hence, if you have lymphoma symptoms and the CLL diagnosis is negative, you can detect the presence of MCL.
    After obtaining the test results, the doctor analyses the following factors: Correlate symptoms with the diagnosis Assess the candidate’s medical history Determine the aggressiveness and stage of the disease The progression of the disease Create a protocol for the treatment and suggest respective therapies
    Even though the condition seems daunting, one does not have to panic about it. The symptoms of CLL are slow and progress eventually. But, with suitable therapies and treatments, you can quickly improve the quality of your life and live well for years.
    CLL is not a severe disease, and you can manage the condition by adopting the following habits:  Manage nausea by taking anti-nausea drugs and therapeutic massages Do more physical exercise to remain active and maintain the stamina of the body Elevate your mood by doing slow exercises like walking and yoga when you feel fatigued Practice self-care by going for spa therapy, steam bath, and community program sessions
    After confirming the presence of chronic lymphocytic leukaemia through a CD23 test, you may be eligible for one of the following treatment plans:  Chemotherapy Radiation therapy Surgery Stem cell therapy Immunotherapy It is important to remember that the therapy of choice depends on the intensity or stage of the disease.

    Why should Apollo be your preferred healthcare partner?

    • 40 Years of legacy and credibility in the healthcare industry.
    • NABL certified multi-channel digital healthcare platform.
    • Affordable diagnostic solutions with timely and accurate test results.
    • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
    • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results