SM/RNP

Mixed connective tissue disease (MCTD) is an uncommon autoimmune disease in which your body’s immune system attacks the cells, considering them a foreign substance. This condition shows signs of several disorders. Cold and numb fingers, swollen hands, and joint pain are some early indicators of this disease.

MCTD symptoms have an association with the following health conditions:

• Scleroderma
• Systemic lupus erythematosus (SLE)
• Primary lupus
• Polymyositis

If you suffer from MCTD, there is a presence of SM and RNP antigens in the blood. The Smith (SM) antibodies are specific for SLE. On the other hand, ribonucleoproteins (RNPs) are antibodies associated with connective tissue disease.

Your doctor may suggest testing for RNP antibodies and detection of SM antibodies if you have the following MCTD symptoms:

• Fatigue
• Fever
• Muscle weakness
• Inflammation of joints

The presence of SM antibody is considered a marker and observed in 20% of SLE patients. The testing for RNP antibodies is observed in 45% of SLE patients. Hence, the combination of SM/RNP antibodies is vital for patients who test positive in an antinuclear antibody test. You are at an increased risk of MCTD  if you are a woman under the age of 50. However, mixed connective tissue disease can happen in people of any age group.

It is crucial to undergo antigen detection to control the symptoms of this condition. Delay in testing can prolong the initialisation of treatment, leading to the following complications:

• Pulmonary hypertension
• Heart disease
• Anaemia
• Hearing loss
• Damage to the nerves
• Impact on the digestive tract

If you notice the common symptoms, your doctor can suggest an SM RNP Test. This medical assessment is a simple blood test that analyses ribonucleoprotein and SM antibodies. Generally, there is no need for special preparations, such as fasting, to undergo the SM RNP Test. After testing, your doctor can evaluate the reports and characterise MCTD by high levels of ribonucleoprotein antibodies. However, a positive RNP result is not considered a marker in the blood test.

The treatment for MCTD depends on the following two factors:

• The severity of the condition
• Organs facing the impact

Your doctor can prescribe non-steroidal anti-inflammatory drugs for MCTD. These medicines can provide symptomatic relief as the cure for this condition is not yet established.

Undergoing a reliable antigen detection test is crucial to controlling the symptoms. Apollo 24|7 offers this assessment at reasonable rates and time.  
 

Frequently asked questions

Is it possible to have lupus disease with negative anti-SM results?

Most people with lupus have a positive antinuclear antibody (ANA) result. However, in rare cases, a negative result does not rule out the possibility of this condition entirely. The occurrence of such a scenario is uncommon. Hence, choosing a reliable lab becomes crucial to increase the chances of getting accurate reports.

What are the different types of lupus?

There are four main types of lupus — systemic lupus erythematosus (SLE), drug-induced lupus, cutaneous lupus, and neonatal lupus. This chronic disease can cause inflammation in various parts of the body. SLE, the most common type, needs a diagnosis of SM antibody to confirm its presence.

Can mixed connective tissue disease lead to weight gain?

Mixed connective tissue disease can lead to issues like cataracts, high blood pressure, and mood swings. In addition, MCTD can also cause weight gain as one of the side effects. Hence, it is vital to undergo a blood test and follow your doctor’s suggestions to control such ill effects.

Which organs does MCTD affect?

MCTD can affect organs like the skin, kidneys, joints, blood vessels, heart, and brain. Young women under the age of 50 are more likely to face this condition. As there is no established cure for this disease, it is vital to appear for an SM RNP Test at the earliest.

Which vitamins and minerals are good for connective tissue?

Vitamin D, C, copper, and calcium are effective in connective tissue recovery. Hence, you should take these supplements after a discussion with your family physician.

What are the common markers for autoimmune disorders?

Antinuclear antibodies are vital markers for various autoimmune conditions. Also, specific markers like an SM antibody are associated with diseases like systemic lupus erythematosus. It is crucial to identify these markers to initiate appropriate and customised treatment depending on your health condition.