Healthcare Essentials

Dolo 650: The Most Sought-After Medicine During the Pandemic

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After the COVID-19 pandemic struck India, Dolo 650 became one of the most prescribed medications. Dolo 650 is an over-the-counter medication used to relieve mild to moderate pain and fever. Let us address some of the frequently asked questions about this all-purpose tablet. 

What is the composition of Dolo 650?

Dolo 650 contains 650 milligrams (mg) of acetaminophen, which is popularly known as paracetamol. 

What are the uses of Dolo 650?

Dolo 650 can be used to reduce fever and relieve different types of pain including pain in the body, head, muscle, back, ear, joints, and oral cavity. Dolo 650 temporarily blocks the release of chemical messengers from the brain that regulate pain and body temperature. 

What is the difference between Dolo 650 and Paracetamol 650?

Dolo 650 containing 650 milligrams (mg) of paracetamol was introduced by Micro Labs Limited in 1973 when most of the other brands were selling paracetamol with 500 mg salt. However, both paracetamol 650 and Dolo 650 contain 650 mg of acetaminophen as a salt. Therefore, both can be used to relieve pain and fever.  

Can Dolo 650 be used on an empty stomach?

Dolo 650 can be taken with or without having a meal. However, doctors advise people to consume food before taking the medicine to avoid gastric problems. 

Can Dolo 650 be used along with alcohol?

Dolo 650 should never be consumed along with alcohol as it increases the risk of developing liver toxicity, which is potentially fatal.

Can Dolo 650 be given to kids?

Dolo 650 has a high dose of paracetamol, therefore it should not be given to children below the age of 12 years. Paracetamol available in the form of syrups, containing low doses of acetaminophen, can be given to children depending on their weight or age, whenever needed. 

What precautions should be taken before using Dolo 650?

While Dolo 650 is considered safe for use, it can be contraindicated in some conditions. Some of these conditions include:

  • Pregnancy: While Dolo 650 is considered safe for use during pregnancy, one must consult a doctor to determine the appropriate doses.
  • Lactation: Dolo 650 can pass on to the child through the mother’s milk while breastfeeding. Therefore, one must consult a doctor before consuming Dolo 650 during lactation.
  • Liver disease: People diagnosed with liver disease should consult a doctor before consuming Dolo 650 as higher doses of the medication can result in liver toxicity.
  • Other medications: Dolo 650 should not be consumed with medications that already contain paracetamol as it can result in toxicity. Dolo 650 should be avoided if the person is already taking blood thinners or medications for epilepsy and fungal infection. 

Are there any side effects of the Dolo 650? 

Dolo 650 rarely causes side effects if taken in the right doses. However, some people may develop an allergic reaction to the medication. One must consult a doctor immediately if they experience symptoms such as:

  • Swelling in the mouth, lips, tongue, face, or throat
  • Dizziness and drowsiness 
  • Itchy, red rashes or blisters on the skin
  • Difficulty in breathing or talking
  • Sudden wheezing (whistling sound on breathing)
  • Low blood pressure
  • Irregular heartbeat
  • Tightness in the chest

Prolonged use or consumption of a high dosage of Dolo 650 can result in liver damage, low platelet count, and low white blood cell count (the immune cells of the body).


Dolo 650 is considered a go-to medication to reduce pain and body temperature. However, pregnant women or those diagnosed with liver or kidney disease must consult their doctor before consuming it. While Dolo 650 rarely shows any side effects, people who develop any kind of allergic reaction on consuming the medication must avoid its use. 

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