Calprotectin Stool Test Overview
Learn about the calprotectin stool test, why it’s done, how to prepare, and what results mean. Understand its role in diagnosing IBD vs IBS and managing gut inflammation.


If you’ve been experiencing persistent stomach pain, diarrhea, or other digestive issues, your doctor may recommend a calprotectin stool test. This simple, non-invasive test helps determine whether inflammation in your intestines is due to conditions like inflammatory bowel disease (IBD) or something less serious, such as irritable bowel syndrome (IBS).
In this article, we’ll explain:
- What the calprotectin stool test is
- Why it’s done
- How to prepare for it
- What the results mean
How you can manage gut inflammation
What Is a Calprotectin Stool Test?
The calprotectin stool test measures the amount of calprotectin—a protein released by white blood cells—in your stool. When there’s inflammation in the intestines, more white blood cells are activated, leading to higher calprotectin levels in your stool.
This test helps doctors distinguish between:
- Inflammatory bowel diseases (IBD) like Crohn’s disease or ulcerative colitis
- Non-inflammatory conditions like IBS
- Unlike invasive procedures like colonoscopies, this test only requires a stool sample, making it a convenient first step in diagnosing gut-related issues.
Why Is This Test Done?
Your doctor may recommend this test if you have symptoms such as:
- Persistent diarrhea
- Abdominal pain or cramping
- Blood or mucus in stool
- Unexplained weight loss
- Fatigue
- Since these symptoms can occur in both IBD and IBS, the calprotectin test helps determine if further testing (like a colonoscopy) is needed.
How to Prepare for the Test?
The good news? No special preparation is needed! Unlike blood tests that require fasting, you can eat and drink normally before giving a stool sample. However, your doctor may advise you to:
- Avoid NSAIDs (like ibuprofen) a few days before the test, as they can increase inflammation.
- Inform your doctor if you’re taking steroids or other anti-inflammatory medications, as they may affect results.
How Is the Sample Collected?
1. You’ll receive a sterile container from the lab.
2. Collect a small stool sample (usually about the size of a walnut).
3. Avoid mixing urine or toilet water with the sample.
4. Seal the container and return it to the lab as soon as possible (some samples need refrigeration).
Consult a Specialist for Personalised Advice
Understanding Your Test Results
Results are usually given in micrograms per gram (µg/g) of stool. Here’s what they mean:
What If Levels Are High?
- Further testing (colonoscopy, endoscopy, or imaging) may be needed to confirm Crohn’s disease or ulcerative colitis.
- Your doctor may prescribe anti-inflammatory medications or dietary changes.
What If Levels Are Normal?
- Symptoms may be due to IBS, infections, or food intolerances.
- Your doctor may recommend dietary adjustments or stress management techniques.
How to Manage Gut Inflammation?
If your test indicates inflammation, here are some ways to support gut health:
1. Dietary Changes
Eat anti-inflammatory foods:
- Fiber-rich foods (oats, bananas, sweet potatoes)
- Probiotics (yogurt, kefir, fermented foods)
- Omega-3 fatty acids (salmon, flaxseeds, walnuts)
Avoid trigger foods:
- Spicy, fried, or processed foods
- Dairy (if lactose intolerant)
- Gluten (if sensitive)
2. Stay Hydrated
Drink plenty of water, herbal teas, or electrolyte solutions to prevent dehydration from diarrhea.
3. Manage Stress
Stress can worsen gut symptoms. Try yoga, meditation, or deep breathing exercises.
4. Follow Medical Advice
If diagnosed with IBD, take prescribed medications (like steroids or biologics) as directed.
Regular follow-ups with your doctor are important.
When to See a Doctor?
Consult a healthcare provider if you experience:
- Blood in stool
- Severe abdominal pain
- Unexplained weight loss
- Persistent diarrhea (lasting weeks)
- Early diagnosis and treatment can help manage conditions like IBD effectively.
Book a Calprotectin Stool Test with Apollo 24|7
If you’re experiencing digestive discomfort, the calprotectin stool test can be a helpful first step. Apollo 24|7 offers easy at-home sample collection and fast, accurate results.
How to Book?
1. Visit Apollo 24|7 or download the app.
2. Search for “Calprotectin Stool Test”.
3. Schedule a test at your convenience.
Get Your Health Assessed
Final Thoughts
Digestive issues can be frustrating, but the calprotectin stool test provides valuable insights into gut health. Whether your symptoms are due to inflammation or a milder condition, early testing can guide the right treatment.
If you’re unsure about your symptoms, don’t hesitate to consult a doctor and get tested.
Consult a Specialist for Personalised Advice