Myeloperoxidase (MPO) Test Overview and Uses
Discover the myeloperoxidase (MPO) test, its purpose, procedure, and role in diagnosing autoimmune conditions and assessing inflammation-related disorders.
Written by Dr. M L Ezhilarasan
Reviewed by Dr. Shaik Abdul Kalam MD (Physician)
Last updated on 1st Sep, 2025
If you or a loved one has been advised to take a Myeloperoxidase (MPO) Test, you might be wondering what it is and why it’s needed. This simple blood test helps doctors assess inflammation in the body, particularly in the arteries, which can be linked to heart disease.
In this article, we’ll explain what the MPO test is, why it’s done, how it helps in diagnosing health conditions, what to expect during the test, tips for managing heart health.
What is the Myeloperoxidase (MPO) Test?
The MPO test measures the level of an enzyme called myeloperoxidase in your blood. This enzyme is produced by white blood cells (particularly neutrophils) and plays a role in fighting infections. However, high levels of MPO can indicate inflammation in the arteries, which may increase the risk of heart disease, heart attack, or stroke.
Consult a Top Cardiologist
Why is the MPO Test Done?
Doctors may recommend this test if:
- You have symptoms of heart disease (chest pain, shortness of breath).
- You have a family history of heart problems.
- You’ve had a previous heart attack or stroke.
- You have risk factors like high cholesterol, diabetes, or high blood pressure.
The test helps assess inflammation in blood vessels, which is not detected by routine cholesterol tests.
How Does MPO Affect Your Health?
High MPO levels suggest:
- Increased inflammation in the arteries.
- Higher risk of plaque buildup, which can block blood flow.
- Possible heart disease or stroke risk.
Unlike cholesterol tests, which measure fat deposits, the MPO test detects active inflammation, helping doctors take preventive steps before serious heart problems develop.
What to Expect During the Test?
The MPO test is a simple blood test:
- A healthcare professional will clean your arm and insert a small needle.
- A small blood sample will be collected in a tube.
- The sample is sent to a lab for analysis.
- Results are usually available within a few days.
There’s no special preparation needed, but check with your doctor if fasting is required.
Understanding Your MPO Test Results
- Normal MPO Levels: Indicate low inflammation in arteries.
- High MPO Levels: May suggest increased heart disease risk.
Your doctor will interpret the results along with other tests (like cholesterol, CRP, or ECG) to determine the next steps.
How to Manage High MPO Levels?
If your MPO levels are high, your doctor may recommend:
1. Lifestyle Changes
- Heart-Healthy Diet: Eat more fruits, vegetables, whole grains, and lean proteins. Reduce processed foods, sugar, and saturated fats.
- Regular Exercise: Aim for 30 minutes of moderate activity (walking, swimming) daily.
- Quit Smoking: Smoking increases inflammation and heart disease risk.
- Manage Stress: Practice yoga, meditation, or deep breathing exercises.
2. Medications (if needed)
- Statins (to lower cholesterol)
- Anti-inflammatory drugs (if necessary)
3. Regular Check-ups
- Monitor blood pressure, cholesterol, and blood sugar levels.
- Follow up with your doctor for repeat tests if needed.
When to See a Doctor?
If you experience:
- Chest pain or discomfort
- Shortness of breath
- Unexplained fatigue
- Family history of heart disease
Consult a doctor immediately. Early detection can prevent serious complications.
Book a Heart Health Check-Up Today
If you’re concerned about heart health or have risk factors, consider scheduling an MPO test or a full cardiac evaluation. Apollo 24|7 offers easy online appointments with expert cardiologists and lab tests from the comfort of your home.
Final Thoughts
The MPO test is a valuable tool for assessing heart disease risk by detecting inflammation in arteries. While high levels can be concerning, early detection and lifestyle changes can significantly improve heart health.
Consult a Top Cardiologist