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Endometrial Cancer Treatment Without Hysterectomy

Wondering if endometrial cancer can be treated without a hysterectomy? Learn about fertility-sparing options, hormone therapy, and non-surgical treatments available today.

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Last updated on 21st Jul, 2025

Endometrial Cancer

Introduction

Endometrial cancer is a type of cancer that affects the lining of the uterus (endometrium). While a hysterectomy—surgical removal of the uterus—is a common treatment, some women may want or need alternatives, especially those who wish to preserve their fertility or avoid major surgery.

If you or a loved one has been diagnosed with endometrial cancer and are exploring treatment options beyond a hysterectomy, this guide will help you understand the possibilities, risks, and benefits.

Understanding Endometrial Cancer

Endometrial cancer occurs when abnormal cells grow uncontrollably in the uterine lining. It is the most common type of uterine cancer and is often detected early because it causes noticeable symptoms like:

  • Abnormal vaginal bleeding, especially after menopause
  • Pelvic pain
  • Unusual discharge
  • Pain during intercourse

Early detection improves treatment success, so if you experience any of these symptoms, consult a doctor immediately.

Who Can Consider Treatment Without Hysterectomy?

Not all patients are candidates for non-hysterectomy treatments. Doctors may consider these options for:

  • Young women who wish to preserve fertility
  • Patients with early-stage, low-grade cancer
  • Those with high surgical risks due to other health conditions

Your doctor will evaluate your cancer stage, grade, and overall health before recommending alternatives.

Consult Top Specialists for Personalised Care

Dr. Rani Bhat, Gynaecological Oncologist

Dr. Rani Bhat

Gynaecological Oncologist

20 Years • MBBS, MS (Obs & Gyn), MRCOG (UK), Fellowship in Gynae-Oncology (Singapore) Fellowship in Gynae-Oncology & Robotic Surgery (Hong Kong) Diploma in Gynaecological Operative Endoscopy (France)

Bengaluru

Apollo Hospitals Bannerghatta Road, Bengaluru

recommendation

100%

(25+ Patients)

1000

Dr. Rupashree Dasgupta. Gynaecological Oncology, Gynaecological Oncology & Robotic Surgery

Dr. Rupashree Dasgupta. Gynaecological Oncology

Gynaecological Oncology & Robotic Surgery

26 Years • MD(Gold Medalist, CMC Vellore), DGO(Gold Medalist, CMC Vellore),DNB, MRCOG(London), MBBS(FOGSI Gold Medalist in Gynaecology).Specialist in Advanced Laparoscopic & Robotic Surgery, UICC Fellowship in Gynae Oncosurgery(BARTS Cancer Institute, LONDON), da Vinci certified training as ROBOTIC CONSOLE Surgeon(USA), Fellowship Gynae Oncosurgery(TMC, Kolkata)

Kolkata

Apollo Multispeciality Hospitals , Kolkata, Kolkata

recommendation

89%

(350+ Patients)

1500

1500

No Booking Fees

Dr. Sai Lakshmi Daayana, Gynaecological Oncologist

Dr. Sai Lakshmi Daayana

Gynaecological Oncologist

18 Years • MBBS, MRCOG

Hyderabad

Apollo Hospitals Jubilee Hills, Hyderabad

recommendation

93%

(200+ Patients)

700

70 Cashback

1000

No Booking Fees

Dr. Swati Shah, Surgical Oncologist

Dr. Swati Shah

Surgical Oncologist

15 Years • DNB Surgical Oncology, certified Robotic Cancer Surgeon

Ahmedabad

Apollo Hospitals Gandhinagar, Ahmedabad

recommendation

93%

(25+ Patients)

1500

150 Cashback

1600

No Booking Fees

Dr Bhawna Garg, Gynaecological Oncologist

Dr Bhawna Garg

Gynaecological Oncologist

26 Years • MBBS, MS, (PGI MS ROHTAK) FELLOWSHIP GYNECOLOGY ONCOLOGY, (CANCER INSTITUTE CHENNAI)

Delhi

Apollo Hospitals Indraprastha, Delhi

1000

150 Cashback

1500

No Booking Fees

Non-Surgical Treatment Options

There are several medical treatments available for eligible patients with early or specific types of endometrial cancer.

1. Hormone Therapy

For women with early-stage, hormone-sensitive endometrial cancer, hormone therapy may help shrink or control cancer growth. Common options include:

  • Progestin Therapy: Taken orally or via hormone-releasing intrauterine devices (IUDs) like Mirena®.
  • Gonadotropin-Releasing Hormone (GnRH) Agonists: Help reduce oestrogen levels and slow cancer growth.

Pros:

  • Non-invasive and fertility-sparing
  • Can be administered at home with regular follow-ups

Cons:

  • Requires frequent monitoring through biopsies and scans
  • Not suitable for high-grade or fast-growing cancers

2. Targeted Drug Therapy & Immunotherapy

For advanced cases, newer treatments like:

  • PARP inhibitors: For patients with specific genetic mutations.
  • Immunotherapy (e.g. Pembrolizumab): Stimulates the immune system to fight cancer cells, especially for mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) tumours.

These drugs help the immune system fight cancer cells without removing the uterus.
Pros:

  • Non-surgical option for selected cases
  • May work when other treatments fail

Cons:

  • Not suitable for all patients
  • Can cause fatigue, skin rash, or immune-related side effects
  • Expensive and not widely accessible in all settings

3. Radiation Therapy

If surgery isn’t an option, radiation can destroy cancer cells. Types include:

  • Brachytherapy: Internal radiation delivered close to the tumour site.
  • External Beam Radiation: A targeted beam directed from outside the body.

Pros:

  • No need for uterus removal
  • Effective in controlling localised cancer

Cons:

  • May affect fertility
  • Can cause temporary fatigue, bowel irritation, or vaginal discomfort

Lifestyle & Supportive Care

While medical treatment is essential, lifestyle changes can improve outcomes:

  • Healthy Diet: Focus on fruits, vegetables, and whole grains.
  • Exercise: Helps maintain a healthy weight, as obesity is a risk factor.
  • Regular Check-ups: Essential for monitoring recurrence.

When to Consider a Hysterectomy

While non-surgical options exist, a hysterectomy may still be the best choice for:

  • High-grade or advanced cancers
  • Cases where hormone therapy fails
  • Postmenopausal women not concerned with fertility

Discuss all risks and benefits with your oncologist.

If you’ve been diagnosed with endometrial cancer and want to explore fertility-sparing or non-surgical treatments, Apollo24|7 can connect you with expert oncologists for personalised care.

Book a consultation today to discuss the best treatment plan for your needs.

Final Thoughts

Endometrial cancer treatment without a hysterectomy is possible for select patients. Early detection, close monitoring, and the right medical approach can help manage the disease while preserving quality of life. Always consult a specialist to determine the best path for you.

If you're exploring your options, Apollo 24|7 can help you connect with leading oncologists for personalised treatment plans and supportive care throughout your journey.

Consult Top Gynaecological Oncologists

Dr. Rani Bhat, Gynaecological Oncologist

Dr. Rani Bhat

Gynaecological Oncologist

20 Years • MBBS, MS (Obs & Gyn), MRCOG (UK), Fellowship in Gynae-Oncology (Singapore) Fellowship in Gynae-Oncology & Robotic Surgery (Hong Kong) Diploma in Gynaecological Operative Endoscopy (France)

Bengaluru

Apollo Hospitals Bannerghatta Road, Bengaluru

recommendation

100%

(25+ Patients)

1000

Dr. Rupashree Dasgupta. Gynaecological Oncology, Gynaecological Oncology & Robotic Surgery

Dr. Rupashree Dasgupta. Gynaecological Oncology

Gynaecological Oncology & Robotic Surgery

26 Years • MD(Gold Medalist, CMC Vellore), DGO(Gold Medalist, CMC Vellore),DNB, MRCOG(London), MBBS(FOGSI Gold Medalist in Gynaecology).Specialist in Advanced Laparoscopic & Robotic Surgery, UICC Fellowship in Gynae Oncosurgery(BARTS Cancer Institute, LONDON), da Vinci certified training as ROBOTIC CONSOLE Surgeon(USA), Fellowship Gynae Oncosurgery(TMC, Kolkata)

Kolkata

Apollo Multispeciality Hospitals , Kolkata, Kolkata

recommendation

89%

(350+ Patients)

1500

1500

No Booking Fees

Dr. Sai Lakshmi Daayana, Gynaecological Oncologist

Dr. Sai Lakshmi Daayana

Gynaecological Oncologist

18 Years • MBBS, MRCOG

Hyderabad

Apollo Hospitals Jubilee Hills, Hyderabad

recommendation

93%

(200+ Patients)

700

70 Cashback

1000

No Booking Fees

Dr. Swati Shah, Surgical Oncologist

Dr. Swati Shah

Surgical Oncologist

15 Years • DNB Surgical Oncology, certified Robotic Cancer Surgeon

Ahmedabad

Apollo Hospitals Gandhinagar, Ahmedabad

recommendation

93%

(25+ Patients)

1500

150 Cashback

1600

No Booking Fees

Dr Bhawna Garg, Gynaecological Oncologist

Dr Bhawna Garg

Gynaecological Oncologist

26 Years • MBBS, MS, (PGI MS ROHTAK) FELLOWSHIP GYNECOLOGY ONCOLOGY, (CANCER INSTITUTE CHENNAI)

Delhi

Apollo Hospitals Indraprastha, Delhi

1000

150 Cashback

1500

No Booking Fees

Consult Top Gynaecological Oncologists

Dr. Rani Bhat, Gynaecological Oncologist

Dr. Rani Bhat

Gynaecological Oncologist

20 Years • MBBS, MS (Obs & Gyn), MRCOG (UK), Fellowship in Gynae-Oncology (Singapore) Fellowship in Gynae-Oncology & Robotic Surgery (Hong Kong) Diploma in Gynaecological Operative Endoscopy (France)

Bengaluru

Apollo Hospitals Bannerghatta Road, Bengaluru

recommendation

100%

(25+ Patients)

1000

Dr. Rupashree Dasgupta. Gynaecological Oncology, Gynaecological Oncology & Robotic Surgery

Dr. Rupashree Dasgupta. Gynaecological Oncology

Gynaecological Oncology & Robotic Surgery

26 Years • MD(Gold Medalist, CMC Vellore), DGO(Gold Medalist, CMC Vellore),DNB, MRCOG(London), MBBS(FOGSI Gold Medalist in Gynaecology).Specialist in Advanced Laparoscopic & Robotic Surgery, UICC Fellowship in Gynae Oncosurgery(BARTS Cancer Institute, LONDON), da Vinci certified training as ROBOTIC CONSOLE Surgeon(USA), Fellowship Gynae Oncosurgery(TMC, Kolkata)

Kolkata

Apollo Multispeciality Hospitals , Kolkata, Kolkata

recommendation

89%

(350+ Patients)

1500

1500

No Booking Fees

Dr. Sai Lakshmi Daayana, Gynaecological Oncologist

Dr. Sai Lakshmi Daayana

Gynaecological Oncologist

18 Years • MBBS, MRCOG

Hyderabad

Apollo Hospitals Jubilee Hills, Hyderabad

recommendation

93%

(200+ Patients)

700

70 Cashback

1000

No Booking Fees

Dr. Swati Shah, Surgical Oncologist

Dr. Swati Shah

Surgical Oncologist

15 Years • DNB Surgical Oncology, certified Robotic Cancer Surgeon

Ahmedabad

Apollo Hospitals Gandhinagar, Ahmedabad

recommendation

93%

(25+ Patients)

1500

150 Cashback

1600

No Booking Fees

Dr Bhawna Garg, Gynaecological Oncologist

Dr Bhawna Garg

Gynaecological Oncologist

26 Years • MBBS, MS, (PGI MS ROHTAK) FELLOWSHIP GYNECOLOGY ONCOLOGY, (CANCER INSTITUTE CHENNAI)

Delhi

Apollo Hospitals Indraprastha, Delhi

1000

150 Cashback

1500

No Booking Fees

Consult Top Specialists for Personalised Care

Dr. Rani Bhat, Gynaecological Oncologist

Dr. Rani Bhat

Gynaecological Oncologist

20 Years • MBBS, MS (Obs & Gyn), MRCOG (UK), Fellowship in Gynae-Oncology (Singapore) Fellowship in Gynae-Oncology & Robotic Surgery (Hong Kong) Diploma in Gynaecological Operative Endoscopy (France)

Bengaluru

Apollo Hospitals Bannerghatta Road, Bengaluru

recommendation

100%

(25+ Patients)

1000

Dr. Rupashree Dasgupta. Gynaecological Oncology, Gynaecological Oncology & Robotic Surgery

Dr. Rupashree Dasgupta. Gynaecological Oncology

Gynaecological Oncology & Robotic Surgery

26 Years • MD(Gold Medalist, CMC Vellore), DGO(Gold Medalist, CMC Vellore),DNB, MRCOG(London), MBBS(FOGSI Gold Medalist in Gynaecology).Specialist in Advanced Laparoscopic & Robotic Surgery, UICC Fellowship in Gynae Oncosurgery(BARTS Cancer Institute, LONDON), da Vinci certified training as ROBOTIC CONSOLE Surgeon(USA), Fellowship Gynae Oncosurgery(TMC, Kolkata)

Kolkata

Apollo Multispeciality Hospitals , Kolkata, Kolkata

recommendation

89%

(350+ Patients)

1500

1500

No Booking Fees

Dr. Sai Lakshmi Daayana, Gynaecological Oncologist

Dr. Sai Lakshmi Daayana

Gynaecological Oncologist

18 Years • MBBS, MRCOG

Hyderabad

Apollo Hospitals Jubilee Hills, Hyderabad

recommendation

93%

(200+ Patients)

700

70 Cashback

1000

No Booking Fees

Dr. Swati Shah, Surgical Oncologist

Dr. Swati Shah

Surgical Oncologist

15 Years • DNB Surgical Oncology, certified Robotic Cancer Surgeon

Ahmedabad

Apollo Hospitals Gandhinagar, Ahmedabad

recommendation

93%

(25+ Patients)

1500

150 Cashback

1600

No Booking Fees

Dr Bhawna Garg, Gynaecological Oncologist

Dr Bhawna Garg

Gynaecological Oncologist

26 Years • MBBS, MS, (PGI MS ROHTAK) FELLOWSHIP GYNECOLOGY ONCOLOGY, (CANCER INSTITUTE CHENNAI)

Delhi

Apollo Hospitals Indraprastha, Delhi

1000

150 Cashback

1500

No Booking Fees

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