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Understanding Malaria and Laboratory Diagnosis

Gain a clear understanding of malaria, including its symptoms, diagnostic tests, and who should get tested. Learn about effective treatment options and essential prevention strategies to protect against this mosquito-borne disease.

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Written by Dr. Siri Nallapu

Reviewed by Dr. Vasanthasree Nair MBBS

Last updated on 25th Aug, 2025

Malaria

Introduction

Malaria is a serious and sometimes life-threatening disease caused by parasites that are transmitted to humans through the bites of infected female Anopheles mosquitoes. It is a major health concern in tropical and subtropical regions, affecting millions of people every year. Early diagnosis and treatment are crucial to prevent severe complications.

In this article, we’ll discuss what malaria is, its symptoms, causes, and how it is diagnosed through laboratory tests. We’ll also share some practical tips for prevention and when to seek medical help.

What is Malaria?

Malaria is an infectious disease caused by Plasmodium parasites, with five species known to infect humans:

  1.  Plasmodium falciparum (most dangerous)
  2.  Plasmodium vivax
  3.  Plasmodium malariae
  4.  Plasmodium ovale
  5.  Plasmodium knowlesi (rare)

When an infected mosquito bites a person, the parasites enter the bloodstream and travel to the liver, where they multiply. Later, they infect red blood cells, leading to symptoms like fever, chills, and fatigue.

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Symptoms of Malaria

Symptoms usually appear 10–15 days after the mosquito bite but can take longer in some cases. Common signs include:

  • High fever with chills and sweating
  • Headache and body aches
  • Fatigue and weakness
  • Nausea and vomiting
  • Muscle pain
  • Jaundice (yellowing of skin and eyes in severe cases)

In severe malaria (often caused by P. falciparum), complications like organ failure, seizures, or coma can occur, requiring immediate medical attention.

How is Malaria Diagnosed?

Since malaria symptoms can resemble other illnesses like flu or dengue, laboratory testing is essential for accurate diagnosis. The main diagnostic methods include:

1. Microscopic Blood Smear Test (Gold Standard)

  • A drop of blood is examined under a microscope to detect malaria parasites.
  • Helps identify the parasite species and determine infection severity.

2. Rapid Diagnostic Tests (RDTs)

  • Quick and simple blood tests that detect malaria proteins (antigens).
  • Results are available in 15–20 minutes.

3. Polymerase Chain Reaction (PCR) Test

  • Highly accurate but takes longer.
  • Used when other tests are inconclusive.

4. Other Tests

  • Complete Blood Count (CBC) – Checks for anemia or low platelets.
  • Liver and Kidney Function Tests – Assess organ damage in severe cases.

Early diagnosis ensures timely treatment and prevents complications.

Get Your Health Assessed

Who Should Get Tested?

You should consider malaria testing if:

  • You live in or have recently traveled to a malaria-prone area.
  • You experience fever, chills, or flu-like symptoms after mosquito exposure.
  • You have unexplained anemia or fatigue.

Treatment and Prevention

Managing malaria effectively requires prompt treatment and proactive prevention strategies to avoid complications and further spread.

Treatment

  • Antimalarial medications (e.g., chloroquine, artemisinin-based therapy) are prescribed based on the parasite type.
  • Severe cases may require hospitalization.

Prevention Tips

  • Use mosquito nets (preferably insecticide-treated).
  • Apply insect repellent (containing DEET or picaridin).
  • Wear long-sleeved clothing in mosquito-prone areas.
  • Take antimalarial prophylaxis if traveling to high-risk regions (consult a doctor).
  • Eliminate stagnant water (mosquito breeding sites).

When to See a Doctor?

Seek medical help immediately if you experience:

  • High fever with shivering
  • Severe headache or confusion
  • Difficulty breathing
  • Persistent vomiting

Early treatment can save lives!

Final Thoughts

Malaria is a preventable and treatable disease, but timely diagnosis is key. If you or a loved one shows symptoms, don’t delay testing.

Consult a Top General Physician for the best advice

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

68 Cashback

450

No Booking Fees

Dr. Aakash Garg, Gastroenterology/gi Medicine Specialist

Dr. Aakash Garg

Gastroenterology/gi Medicine Specialist

12 Years • MBBS, DNB (Medicine), DrNB (Gastroentrology).

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

98%

(125+ Patients)

800

40 Cashback

800

No Booking Fees

Dr. Thirupathy K S, General Physician/ Internal Medicine Specialist

Dr. Thirupathy K S

General Physician/ Internal Medicine Specialist

11 Years • MD

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

recommendation

96%

(75+ Patients)

500

No Booking Fees

Dr. Rajib Ghose, General Physician/ Internal Medicine Specialist

Dr. Rajib Ghose

General Physician/ Internal Medicine Specialist

26 Years • MBBS

Kolkata

B Ghose Foundation Doctor's Chamber, Kolkata

recommendation

92%

(25+ Patients)

1063

850

Dr. Rajib Ghose, General Practitioner

Dr. Rajib Ghose

General Practitioner

25 Years • MBBS

East Midnapore

VIVEKANANDA SEBA SADAN, East Midnapore

950

850

Consult a Top General Physician for the best advice

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

68 Cashback

450

No Booking Fees

Dr. Aakash Garg, Gastroenterology/gi Medicine Specialist

Dr. Aakash Garg

Gastroenterology/gi Medicine Specialist

12 Years • MBBS, DNB (Medicine), DrNB (Gastroentrology).

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

98%

(125+ Patients)

800

40 Cashback

800

No Booking Fees

Dr. Thirupathy K S, General Physician/ Internal Medicine Specialist

Dr. Thirupathy K S

General Physician/ Internal Medicine Specialist

11 Years • MD

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

recommendation

96%

(75+ Patients)

500

No Booking Fees

Dr. Rajib Ghose, General Physician/ Internal Medicine Specialist

Dr. Rajib Ghose

General Physician/ Internal Medicine Specialist

26 Years • MBBS

Kolkata

B Ghose Foundation Doctor's Chamber, Kolkata

recommendation

92%

(25+ Patients)

1063

850

Dr. Rajib Ghose, General Practitioner

Dr. Rajib Ghose

General Practitioner

25 Years • MBBS

East Midnapore

VIVEKANANDA SEBA SADAN, East Midnapore

950

850

Consult a Top General Physician for the best advice

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

68 Cashback

450

No Booking Fees

Dr. Aakash Garg, Gastroenterology/gi Medicine Specialist

Dr. Aakash Garg

Gastroenterology/gi Medicine Specialist

12 Years • MBBS, DNB (Medicine), DrNB (Gastroentrology).

Bilaspur

Apollo Hospitals Seepat Road, Bilaspur

recommendation

98%

(125+ Patients)

800

40 Cashback

800

No Booking Fees

Dr. Thirupathy K S, General Physician/ Internal Medicine Specialist

Dr. Thirupathy K S

General Physician/ Internal Medicine Specialist

11 Years • MD

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

recommendation

96%

(75+ Patients)

500

No Booking Fees

Dr. Rajib Ghose, General Physician/ Internal Medicine Specialist

Dr. Rajib Ghose

General Physician/ Internal Medicine Specialist

26 Years • MBBS

Kolkata

B Ghose Foundation Doctor's Chamber, Kolkata

recommendation

92%

(25+ Patients)

1063

850

Dr. Rajib Ghose, General Practitioner

Dr. Rajib Ghose

General Practitioner

25 Years • MBBS

East Midnapore

VIVEKANANDA SEBA SADAN, East Midnapore

950

850

Get Your Health Assessed

870(₹2175)60% off

395(₹988)60% off

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