HLA-B27 Test Overview and Information
Discover the HLA-B27 test, its purpose, procedure, and role in diagnosing autoimmune conditions like ankylosing spondylitis and other inflammatory disorders.
If you or a loved one has been experiencing joint pain, stiffness, or inflammation, your doctor may have recommended an HLA-B27 test. This simple blood test can help diagnose certain autoimmune conditions, particularly those affecting the spine and joints.
In this article, we’ll explain what the HLA-B27 test is, why it’s important, and how it can help in diagnosing and managing certain health conditions.
What is the HLA-B27 Test?
The HLA-B27 test checks for the presence of a specific protein called Human Leukocyte Antigen B27 (HLA-B27) on the surface of your white blood cells. This protein is part of your immune system and plays a role in how your body responds to infections and diseases.
While having the HLA-B27 gene doesn’t always mean you’ll develop an autoimmune disease, it is associated with certain inflammatory conditions, such as:
- Ankylosing Spondylitis (a type of arthritis affecting the spine)
- Reactive Arthritis (joint pain triggered by infections)
- Psoriatic Arthritis (arthritis linked with psoriasis)
- Juvenile Rheumatoid Arthritis (arthritis in children)
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Why is the HLA-B27 Test Done?
Your doctor may recommend this test if you have symptoms like:
- Chronic back pain and stiffness (especially in the morning)
- Swollen, painful joints
- Eye inflammation (uveitis)
- Skin rashes (psoriasis)
- Digestive issues (linked with inflammatory bowel disease)
The test helps confirm or rule out autoimmune conditions associated with HLA-B27.
How is the Test Performed?
The HLA-B27 test is a simple blood test. A healthcare professional will:
1. Clean the area (usually your arm) with an antiseptic.
2. Insert a small needle to draw a blood sample.
3. Send the sample to a lab for analysis.
No special preparation is needed, and you can resume normal activities afterward.
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Understanding Your Test Results
Below are the interpretation of the test results,
- Positive Result: Means HLA-B27 is present in your blood. This doesn’t always mean you have an autoimmune disease, but it increases the likelihood.
- Negative Result: Means HLA-B27 is not detected. However, some people with autoimmune conditions may still test negative.
Your doctor will interpret the results along with your symptoms and other tests to make a diagnosis.
What If You Test Positive for HLA-B27?
A positive result doesn’t guarantee you’ll develop an autoimmune disease, but it does mean you may be at higher risk. Here’s what you can do:
1. Monitor Symptoms
- Keep track of joint pain, stiffness, or swelling.
- Report any new symptoms (eye redness, skin rashes) to your doctor.
2. Stay Active
- Gentle exercises (yoga, swimming, walking) can help maintain joint flexibility.
- Avoid prolonged sitting or inactivity.
3. Eat an Anti-Inflammatory Diet
- Include fruits, vegetables, whole grains, and omega-3-rich foods (like fish, flaxseeds).
- Reduce processed foods, sugar, and excessive red meat.
4. Manage Stress
- Stress can worsen inflammation and practice relaxation techniques like meditation.
5. Regular Check-ups
- Follow up with a rheumatologist if needed.
When to See a Doctor?
If you experience:
- Persistent joint pain or stiffness
- Swelling in the knees, ankles, or lower back
- Eye redness or vision changes
- Unexplained rashes or digestive issues
Consult a doctor for further evaluation. Early diagnosis can help manage symptoms better.
Book an HLA-B27 Test with Apollo 24|7
If your doctor has recommended an HLA-B27 test, you can easily schedule a blood test through Apollo 24|7.
Final Thoughts
The HLA-B27 test is a helpful tool in diagnosing autoimmune conditions, especially those affecting joints and the spine. While a positive result doesn’t always mean you’ll develop a disease, it’s important to stay aware of symptoms and maintain a healthy lifestyle. If you have concerns about joint pain or related symptoms, talk to your doctor and consider getting tested. Early detection and proper care can make a big difference in managing your health.
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Dr. Sandhya Chandel
General Physician/ Internal Medicine Specialist
16 Years • MBBS, MD (Int. Med.), IDCCM
Bilaspur
Apollo Hospitals Seepat Road, Bilaspur
(125+ Patients)
Dr. Dhanraj K
General Physician/ Internal Medicine Specialist
25 Years • MBBS, MD Internal Medicine - Osmania Medical College, Hyderabad
Hyderabad
Apollo Hospitals Jubilee Hills, Hyderabad
(375+ Patients)
Dr. Anand Ravi
General Physician
2 Years • MBBS
Bengaluru
PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru
Dr Syed Mateen Pasha
General Physician
2 Years • MBBS
Bengaluru
PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru
Dr. Mohamed Azeem
General Physician/ Internal Medicine Specialist
2 Years • MBBS,MD(Internal Medicine) CCEBDM
Karaikudi
Apollo Hospitals Karaikudi, Karaikudi
Consult a Top Specialist
Dr. Sandhya Chandel
General Physician/ Internal Medicine Specialist
16 Years • MBBS, MD (Int. Med.), IDCCM
Bilaspur
Apollo Hospitals Seepat Road, Bilaspur
(125+ Patients)
Dr. Dhanraj K
General Physician/ Internal Medicine Specialist
25 Years • MBBS, MD Internal Medicine - Osmania Medical College, Hyderabad
Hyderabad
Apollo Hospitals Jubilee Hills, Hyderabad
(375+ Patients)
Dr. Anand Ravi
General Physician
2 Years • MBBS
Bengaluru
PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru
Dr Syed Mateen Pasha
General Physician
2 Years • MBBS
Bengaluru
PRESTIGE SHANTHINIKETAN - SOCIETY CLINIC, Bengaluru
Dr. Mohamed Azeem
General Physician/ Internal Medicine Specialist
2 Years • MBBS,MD(Internal Medicine) CCEBDM
Karaikudi
Apollo Hospitals Karaikudi, Karaikudi
Get Your Health Assessed
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