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Understanding the Stages of Sepsis

Understand the stages of sepsis, from early infection to severe complications. Learn how prompt recognition and treatment can improve outcomes and support recovery during this critical condition

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Written by Dr. J T Hema Pratima

Reviewed by Dr. Siri Nallapu MBBS

Last updated on 21st Aug, 2025

Understanding the Stages of Sepsis

Sepsis is a serious medical condition that occurs when the body’s response to an infection spirals out of control, leading to widespread inflammation and potential organ failure. It can be life-threatening if not treated promptly. Understanding the stages of sepsis can help you recognise the symptoms early and seek medical attention in time.

What is Sepsis?

Sepsis is not an infection itself but rather the body’s extreme reaction to an infection—bacterial, viral, or fungal. When the immune system overreacts, it can damage tissues and organs, leading to severe complications.

Sepsis progresses in three main stages:

1. Sepsis
2. Severe Sepsis
3. Septic Shock

Each stage has distinct symptoms and requires urgent medical care.

Stage 1: Sepsis

Sepsis begins when an infection triggers a strong immune response. Common infections that can lead to sepsis include:

  •  Pneumonia
  • Urinary tract infections (UTIs)
  • Skin infections
  • Abdominal infections (like appendicitis)

Symptoms of Sepsis

Look out for these signs, especially if you have an ongoing infection:

  • Fever (above 101°F or below 96.8°F)
  • Fast heart rate (more than 90 beats per minute)
  • Rapid breathing (more than 20 breaths per minute)
  • Confusion or disorientation
  • Extreme fatigue

If you notice these symptoms, seek medical help immediately. Early treatment can prevent progression to severe sepsis.

Consult Top Specialists

Dr. Chethan T L, General Physician/ Internal Medicine Specialist

Dr. Chethan T L

General Physician/ Internal Medicine Specialist

5 Years • MBBS, MD, DNB (General Medicine)

Bengaluru

Apollo Medical Center, Marathahalli, Bengaluru

550

83 Cashback

Dr. Rajib Ghose, General Practitioner

Dr. Rajib Ghose

General Practitioner

25 Years • MBBS

East Midnapore

VIVEKANANDA SEBA SADAN, East Midnapore

950

850

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

68 Cashback

450

No Booking Fees

Dr. Sunil Nigam, General Physician/ Internal Medicine Specialist

Dr. Sunil Nigam

General Physician/ Internal Medicine Specialist

48 Years • MBBS, MD ( General Medicine)

New Delhi

VIVA VISION, New Delhi

1000

Stage 2: Severe Sepsis

If sepsis is not treated, it can progress to severe sepsis, where organ dysfunction begins. This means one or more organs (like the kidneys, heart, or lungs) start failing.

  • Symptoms of Severe Sepsis
  • Difficulty breathing (due to lung failure)
  • Low urine output (kidney failure)
  • Sudden confusion or dizziness (brain dysfunction)
  • Severe abdominal pain
  • Abnormal blood clotting (leading to bruising or bleeding)

At this stage, hospitalisation is critical. Doctors may administer IV antibiotics, fluids, and oxygen support.

Stage 3: Septic Shock

The most dangerous stage is septic shock, where blood pressure drops dangerously low, and organs fail despite treatment. This can be fatal if not managed urgently.

Symptoms of Septic Shock

  • Extremely low blood pressure (not improving with fluids)
  • Cold, clammy skin
  • Loss of consciousness
  • Difficulty staying awake

Septic shock requires intensive care, including medications to stabilise blood pressure and life support if needed.

Who is at Risk?

While anyone can develop sepsis, some people are at higher risk:

  • Older adults (65+)
  • Infants and young children
  • People with weakened immune systems (diabetes, cancer, HIV)
  • Those with chronic illnesses (kidney disease, lung disease)
  • Recent surgery or hospitalisation patients

How to Prevent Sepsis?

Here’s how you can prevent sepsis:

1. Treat Infections Early: Don’t ignore infections; seek medical help.
2. Practice Good Hygiene: Wash hands regularly, keep wounds clean.
3. Stay Up-to-Date on Vaccinations: Flu, pneumonia, and other vaccines help prevent infections.
4. Manage Chronic Conditions: Keep diabetes, heart disease, etc., under control.
5. Know the Signs: Early recognition saves lives.

When to See a Doctor?

If you or a loved one has an infection and develops:
 

  • High fever with chills
  • Extreme weakness or confusion
  • Difficulty breathing
  • Low urine output

Do not wait—seek emergency care immediately.

How Apollo 24|7 Can Help?

If you suspect sepsis or have recurring infections, consult a doctor right away. Apollo 24|7 offers:

  • Expert consultations with specialists
  • Lab tests to detect infections early
  • Emergency care support

You can book a consultation or schedule tests through the Apollo 24|7 app or website for quick and reliable healthcare.

Conclusion

Sepsis is a medical emergency, and recognising its stages can save lives. Stay vigilant, act fast, and prioritise early treatment. If you have any concerns about infections or sepsis symptoms, don’t hesitate to reach out to a healthcare provider.

Consult Top Specialists

Dr. Chethan T L, General Physician/ Internal Medicine Specialist

Dr. Chethan T L

General Physician/ Internal Medicine Specialist

5 Years • MBBS, MD, DNB (General Medicine)

Bengaluru

Apollo Medical Center, Marathahalli, Bengaluru

550

83 Cashback

Dr. Rajib Ghose, General Practitioner

Dr. Rajib Ghose

General Practitioner

25 Years • MBBS

East Midnapore

VIVEKANANDA SEBA SADAN, East Midnapore

950

850

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

68 Cashback

450

No Booking Fees

Dr. Sunil Nigam, General Physician/ Internal Medicine Specialist

Dr. Sunil Nigam

General Physician/ Internal Medicine Specialist

48 Years • MBBS, MD ( General Medicine)

New Delhi

VIVA VISION, New Delhi

1000

Consult Top Specialists

Dr. Swathi Reddy Perugu, General Physician/ Internal Medicine Specialist

Dr. Swathi Reddy Perugu

General Physician/ Internal Medicine Specialist

7 Years • MBBS, MD (General Medicine)

Hyderabad

Health plus, Hyderabad

625

Dr. Chethan T L, General Physician/ Internal Medicine Specialist

Dr. Chethan T L

General Physician/ Internal Medicine Specialist

5 Years • MBBS, MD, DNB (General Medicine)

Bengaluru

Apollo Medical Center, Marathahalli, Bengaluru

550

83 Cashback

Dr. Rajib Ghose, General Practitioner

Dr. Rajib Ghose

General Practitioner

25 Years • MBBS

East Midnapore

VIVEKANANDA SEBA SADAN, East Midnapore

950

850

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

68 Cashback

450

No Booking Fees

Dr. Sunil Nigam, General Physician/ Internal Medicine Specialist

Dr. Sunil Nigam

General Physician/ Internal Medicine Specialist

48 Years • MBBS, MD ( General Medicine)

New Delhi

VIVA VISION, New Delhi

1000

Consult Top Specialists

Dr. Swathi Reddy Perugu, General Physician/ Internal Medicine Specialist

Dr. Swathi Reddy Perugu

General Physician/ Internal Medicine Specialist

7 Years • MBBS, MD (General Medicine)

Hyderabad

Health plus, Hyderabad

625

Dr. Chethan T L, General Physician/ Internal Medicine Specialist

Dr. Chethan T L

General Physician/ Internal Medicine Specialist

5 Years • MBBS, MD, DNB (General Medicine)

Bengaluru

Apollo Medical Center, Marathahalli, Bengaluru

550

83 Cashback

Dr. Rajib Ghose, General Practitioner

Dr. Rajib Ghose

General Practitioner

25 Years • MBBS

East Midnapore

VIVEKANANDA SEBA SADAN, East Midnapore

950

850

Dr. Mohamed Azeem, General Physician/ Internal Medicine Specialist

Dr. Mohamed Azeem

General Physician/ Internal Medicine Specialist

2 Years • MBBS,MD(Internal Medicine) CCEBDM

Karaikudi

Apollo Hospitals Karaikudi, Karaikudi

450

68 Cashback

450

No Booking Fees

Dr. Sunil Nigam, General Physician/ Internal Medicine Specialist

Dr. Sunil Nigam

General Physician/ Internal Medicine Specialist

48 Years • MBBS, MD ( General Medicine)

New Delhi

VIVA VISION, New Delhi

1000

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