Thrombophilia During Pregnancy: Overview and Management
Learn about thrombophilia during pregnancy, its symptoms, causes, risks, and safe management strategies. Discover how early detection and care can ensure a healthy pregnancy.
Written by Dr. D Bhanu Prakash
Reviewed by Dr. Rohinipriyanka Pondugula MBBS
Last updated on 28th Aug, 2025
Pregnancy is a beautiful journey, but it can also bring certain health challenges. One such condition that expecting mothers should be aware of is thrombophilia, a blood disorder that increases the risk of developing blood clots. While it may sound concerning, with proper awareness and care, thrombophilia can be managed effectively during pregnancy.
This article will help you understand what thrombophilia is, its symptoms, causes, and how it can affect pregnancy. We’ll also share practical tips for managing the condition and ensuring a healthy pregnancy.
What is Thrombophilia?
Thrombophilia is a condition where the blood has an increased tendency to form clots. While blood clotting is a natural process that prevents excessive bleeding, thrombophilia can lead to abnormal clotting, which may block blood vessels.
During pregnancy, the risk of blood clots naturally increases due to hormonal changes and reduced blood flow in the legs. If a woman has thrombophilia, this risk becomes even higher, potentially leading to complications like:
- Deep Vein Thrombosis (DVT) – A clot in the deep veins, usually in the legs.
- Pulmonary Embolism (PE) – A life-threatening condition where a clot travels to the lungs.
- Miscarriage or stillbirth – Due to clots affecting the placenta.
Symptoms of Thrombophilia During Pregnancy
Many women with thrombophilia may not experience symptoms until a clot forms. However, some warning signs include:
- Swelling, pain, or redness in the legs (possible DVT).
- Shortness of breath or chest pain (possible PE).
- Recurrent miscarriages (especially in the second or third trimester).
- High blood pressure or preeclampsia-like symptoms.
If you notice any of these symptoms, consult your doctor immediately. Early detection can prevent serious complications.
Causes and Risk Factors
Thrombophilia can be inherited (genetic) or acquired (developed later in life).
1. Inherited Thrombophilia
- Factor V Leiden mutation – The most common genetic cause.
- Prothrombin gene mutation – Increases clotting risk.
- Protein C or S deficiency – Natural anticoagulants that are low or missing.
2. Acquired Thrombophilia
- Antiphospholipid syndrome (APS) – An autoimmune disorder that increases clotting.
- Prolonged immobility (e.g., bed rest).
- Obesity, smoking, or certain medications.
If you have a family history of blood clots or previous pregnancy complications, your doctor may recommend testing for thrombophilia.
How Thrombophilia Affects Pregnancy
Pregnancy already increases clotting risk due to:
- Higher estrogen levels – Makes blood thicker.
- Pressure on veins – Reduced blood flow in the legs.
- Placental clotting – Can restrict oxygen and nutrients to the baby.
Consult a Gynecologist for the best advice
Women with thrombophilia are at higher risk for:
- Miscarriage or stillbirth (if clots block placental blood flow).
- Preeclampsia (high blood pressure affecting the placenta).
- Premature birth or low birth weight.
The good news? With proper care, most women with thrombophilia have healthy pregnancies!
Managing Thrombophilia During Pregnancy
1. Medical Management
- Blood thinners (Anticoagulants) – Like low-molecular-weight heparin (LMWH) injections, which are safe during pregnancy.
- Aspirin (in some cases) – Helps prevent clotting in mild cases.
- Regular monitoring – Blood tests and ultrasounds to check baby’s growth and blood flow.
2. Lifestyle Adjustments
- Stay active – Gentle walks improve circulation.
- Wear compression stockings – Helps prevent leg clots.
- Stay hydrated – Reduces blood thickness.
- Avoid long periods of sitting – Take breaks if traveling.
3. Diet Tips
- Eat foods rich in omega-3 (like fish, flaxseeds) – Supports blood flow.
- Limit processed foods – High salt can increase swelling.
- Stay hydrated – Water helps prevent clots.
When to Seek Help?
If you:
- Have a family history of blood clots.
- Experienced recurrent miscarriages.
- Notice swelling, pain, or breathing difficulties.
Consult a doctor immediately. Early intervention can make a big difference!
Can You Get Tested for Thrombophilia?
Yes! If you have risk factors, your doctor may recommend:
- Blood tests (to check clotting factors).
- Genetic testing (for inherited conditions).
- Ultrasound (Doppler) – To check for existing clots.
At Apollo 24|7, you can easily book a consultation or lab test to assess your risk. Early detection ensures better care!
Final Thoughts
Thrombophilia during pregnancy requires extra care, but it doesn’t mean you can’t have a healthy baby. With proper medical supervision, lifestyle adjustments, and timely interventions, most women manage well.
If you suspect any symptoms or have a history of clotting disorders, don’t hesitate to reach out to your healthcare provider.
Consult a Gynecologist for the best advice
Consult a Gynecologist for the best advice
Dr. Mona Yadav
Obstetrician and Gynaecologist
19 Years • MBBS, MD (Obstetrics & Gynaecology)
Dombivli
Nulife multispeciality, Dombivli
Dr. Parul Sharma
Obstetrician and Gynaecologist
8 Years • MBBS, MS (Obstetrics & Gynaecology)
New Delhi
THE DOCTORS NESST, New Delhi
Dr. Asha Rani Singh
Obstetrician and Gynaecologist
24 Years • MBBS DGO
Delhi
Dr Asha Rani Singh Clinic, Delhi
Dr. K Anusha
Obstetrician and Gynaecologist
4 Years • MBBS, DGO
Yemmiganur
SRINIVASAA HOSPITAL, Yemmiganur
Dr. Sridevi Matta
Obstetrician and Gynaecologist
28 Years • MS ( OBG ), DGO, DNB Obstetrics & Gynaecology
Chinagadila
Apollo Hospitals Health City Unit, Chinagadila
(175+ Patients)
Consult a Gynecologist for the best advice
Dr. Mona Yadav
Obstetrician and Gynaecologist
19 Years • MBBS, MD (Obstetrics & Gynaecology)
Dombivli
Nulife multispeciality, Dombivli
Dr. Parul Sharma
Obstetrician and Gynaecologist
8 Years • MBBS, MS (Obstetrics & Gynaecology)
New Delhi
THE DOCTORS NESST, New Delhi
Dr. Asha Rani Singh
Obstetrician and Gynaecologist
24 Years • MBBS DGO
Delhi
Dr Asha Rani Singh Clinic, Delhi
Dr. K Anusha
Obstetrician and Gynaecologist
4 Years • MBBS, DGO
Yemmiganur
SRINIVASAA HOSPITAL, Yemmiganur
Dr. Sridevi Matta
Obstetrician and Gynaecologist
28 Years • MS ( OBG ), DGO, DNB Obstetrics & Gynaecology
Chinagadila
Apollo Hospitals Health City Unit, Chinagadila
(175+ Patients)
