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Anca Test in Sector 50, Gurgaon

Also Known as Anca Profile (MPO & PR3)

No preparation required

MRP 6875 60% off
2750

testsTest(s) Included (2)

  • Anca Test

    2 tests included

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About

blood sample
SAMPLE TYPE

BLOOD

Gender
GENDER

Both

users
AGE GROUP

7 years & above

The ANCA Profile test checks your blood for Antineutrophil Cytoplasmic Antibodies (ANCAs). Your immune system produces proteins called antibodies to fight external invaders like germs and viruses.

However, ANCAs mistakenly target healthy neutrophils, a kind of white blood cells that can lead to Autoimmune Vasculitis.

Blood vessel swelling and inflammation are brought on by Autoimmune Vasculitis. Blood vascular inflammation can result in significant medical issues depending on which physiological systems and blood vessels are impacted.

ANCA exists in two primary varieties. Each one focuses on a distinct protein found within white blood cells:

  • pANCA, which goes after the MPO (Myeloperoxidase) protein  
  • cANCA, which attacks the PR3 (Proteinase 3) protein

Whether you possess one or both kinds of antibodies is determined by the ANCA Profile test offered by Apollo 24|7. The package includes two tests, one for pANCA and the other for cANCA. This can assist your doctor in identifying and treating your illness.

The most popular method for determining if you have Autoimmune Vasculitis is to undergo an ANCA Profile test. This condition exists in various forms. Each variety affects various blood vessels and regions of the body, but they all result in blood vessel enlargement and inflammation. The following are examples of Autoimmune Vasculitis:

  • GPA: Wegener's disease, popularly known as Granulomatosis with Polyangiitis (GPA). It can have an impact on the kidneys, lungs, and sinuses 
  • MPA: Miniature polyangiitis (MPA) is a condition that may impact the neurological system, skin, lungs, kidneys, and other body organs 
  • EGPA: Formerly known as Churg-Strauss syndrome, Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a condition that typically affects the lungs and the skin 
  • PAN: Polyarteritis Nodosa is a condition that frequently impacts the central nervous system, kidneys, heart, and skin

If you exhibit signs of Autoimmune Vasculitis, your doctor might recommend an ANCA Profile test. These signs include:

  • Fever  
  • Exhaustion  
  • Aches in the joints or muscles
  • Weight loss

Your symptoms may also impact one or more particular body organs. Organs frequently impacted, and the indications they bring on are as follows:

  • Eyes: Redness, haziness, and blindness 
  • Ears: Tinnitus (ringing sound in the ears), loss of hearing 
  • Sinuses: Runny nose, bleeding from the nose, and sinus pain 
  • Skin: Rashes, blisters, or ulcers, a particular kind of deep sore that heals slowly or keeps recurring 
  • Lungs: Coughing, breathing issues, and chest pain 
  • Kidneys: Frothy urine and blood in the urine, which are symptoms of urine protein contamination 
  • Nervous system: Stinging and numbness in different body parts

A tiny needle will be used to extract a blood specimen from a vein in the arm during the ANCA Profile test. Following the insertion of the needle, a minute quantity of blood will be collected in a vial or test tube. When the needle is inserted, you can feel a little discomfort. 
 

faqFrequently Asked Questions (FAQs)

What does an ANCA Profile test with PR3 and MPO entail?

You are prescribed an ANCA Profile test and tests for MPO and PR3 if your signs and symptoms point to Systemic Autoimmune Vasculitis. Early indications of the illness could include fever, weariness, weight loss, muscle or joint ache, and night sweats.

What does ANCA positivity indicate?

You might have Autoimmune Vasculitis if the results of your ANCA test are positive. It can also indicate whether pANCAs and cANCAs were discovered. This can assist in identifying the kind of vasculitis you suffer. A biopsy may be required to verify the diagnosis regardless of the type of antibodies discovered.

Is ANCA potentially fatal?

The intricate nature of ANCA vasculitis treatment necessitates the involvement of experts in the affected organs. Different body regions can sustain injury when autoantibodies (ANCAs) target them. Scarring may result from blood vessel inflammation, particularly if it persists for an extended period.

What results in High PR3?

Several factors, including increased or decreased synthesis or elimination, inflammatory activity, and mononuclear or neutrophil cell leakage or degranulation, could account for elevated PR3 levels in vasculitis patients.

How is Autoimmune Vasculitis treated?

Glucocorticoids are typically used to treat Autoimmune Vasculitis. Prednisolone is one of the glucocorticoids that has anti-inflammatory properties. They can lessen immune system damage by lowering inflammation. These are the most widely used remedies for ANCA vasculitis and are frequently combined with other treatments to bring on and sustain remission.

What does MPO inflammation entail?

MPO is an inflammatory enzyme produced by white blood cells that assess the disease activity on the arterial wall's luminal side. MPO is secreted by invading macrophages into the inflamed or injured arterial wall, where it accumulates.

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