apollo

Anti-Dsg-I (Pemphigus Foliaceus) in Pragathi Enclave, Hyderabad

No preparation required

MRP360025% off
2700
circle logo₹135 cashback

testsTest(s) Included (1)

  • Anti-Dsg-I (Pemphigus Foliaceus)

    1 test included

    expand

About

blood sample
Sample

BLOOD

Gender
Gender

Both

users
Age group

7 years & above

The anti-DSG-1 test is a screening test used for diagnosing an autoimmune disease called pemphigus foliaceus. This condition is characterised by the formation of itchy blisters or sores on the skin, mouth, or genitals.

Pemphigus foliaceus is a rare and relatively benign form of pemphigus. It is caused by the loss of intercellular adhesions in keratinocytes, which are located in the upper part of the epidermis. This leads to the formation of superficial blisters that appear when the skin is rubbed.

Keratinocytes are the most prominent cells making up the epidermis, constituting about 90% of the epidermal skin cells. These cells are glued to each other at unique sticky spots called desmosomes. 

In pemphigus foliaceus, the autoantibodies target and bind to the desmoglein-1 proteins, also known as the DSG-1 proteins. As a result of this action, the keratinocytes separate from each other, and the resultant replacement is a fluid—the blister. 

These blisters also rupture easily since they are formed near the surface of the skin. The rupturing can cause fluid to ooze out. Once the blisters break open, they can form sores on the skin. Gradually, these sores scale and crust over.

The anti-DSG-1 test is used to detect the presence of these DSG-1 proteins to help diagnose pemphigus foliaceus. It is a standard blood test, where the clinical lab technician draws blood from a vein in the arm and sends it for analysis in a labelled container. The subsequent results can help determine if the patient is suffering from pemphigus foliaceus or not.

The anti-DSG-1 test is a useful indirect immunofluorescence assay to confirm the diagnosis of Pdmphigus foliaceus and also, to know the improvement during and after treatment. Physicians advice to do both DsG1 and DsG3 antibodies as an initial test in order to identify overlapping of clinical types. A skin biopsy can also be done from the blister for routine HPE and Direct immunofluorescence on the tissue. 

Some of the reference values for the results of the pemphigus foliaceus diagnostic test are:

  • If the results show a value of less than 20 RU/ml (relative units/millilitre), then the patient might not have pemphigus foliaceus.
  • If the obtained results have a value equal to or more than 20 RU/ml, then further tests should be done to confirm the diagnosis of the disease.

In many patients, the DSG-1 antibody concentrations may be correlated with disease activity. Patients with a severe case of pemphigus foliaceus may have a high concentration of DSG-1 antibodies. 

Apollo 24|7 offers a comprehensive anti-DSG-1 test in multiple labs all over the country. A doctor might recommend this lab test if there is an emergence of fluid-filled blisters on the back, chest, and shoulders.

Although pemphigus foliaceus is not painful, it is characterised by a sharp pain or burning sensation in the area of the blisters. It is vital to get medical intervention for this condition since the resultant bacteria may leak into the bloodstream and cause sepsis.
 

Medically reviewed by Dr. Ravichandran G, Sr. Dermatologist, Apollo Hospitals Greams Road, Chennai
 

faqFrequently Asked Questions (FAQs)

What can be the causes of pemphigus foliaceus?

Since pemphigus foliaceus is an autoimmune disease, it is likely to occur when the antibodies mistakenly target the body’s own tissues. The chance of getting affected by this disease can be due to many factors. These are: Genetics Being exposed to the sun Getting an insect bite, especially in South American countries Side effects of drugs like penicillamine, candesartan and non-steroidal anti-inflammatory drugs, among others.

Can the anti-DSG-1 test be used to treat pemphigus foliaceus?

No, the anti-DSG-1 test is strictly a diagnostic test used to determine the presence of DSG-1 antibodies in the body. If the results show more than the required amount (> 20 RU/ml), the doctor might suggest a suitable treatment plan.

What is DSG-1 in the human body?

DSG-1 stands for desmoglein-1 proteins. These are compounds used to bind the keratinocytes present in the epidermal skin cells. These proteins are vital to maintain tissue integrity and facilitate cell-to-cell communication for proper functioning.

What are the side effects associated with the anti-DSG-1 test?

The anti-DSG-1 test is a blood test known to have minimal to no complications. At most, there will be slight bruising at the spot where the technician draws the blood. However, this bruising fades away rapidly without the need for any external medication or interference.

What are some common symptoms indicating the likelihood of having pemphigus foliaceus?

Apart from the formation of blisters all over the body, other minor indications may point toward pemphigus foliaceus. These are: Redness or swelling Spreading of the blisters rapidly Weakness or muscle aches Fever and chills

Is pemphigus foliaceus treatable?

After confirming the diagnosis, the doctor may suggest treatment based on the intensity of the condition. Although pemphigus foliaceus is not entirely curable, there are treatment methods that can curb its symptoms. Moreover, it poses no threat to life expectancy.

Most Popular tests & packages

Complete Blood Count (CBC) in Pragathi Enclave, Hyderabad | Glucose, Fasting in Pragathi Enclave, Hyderabad | HbA1c, Glycated Hemoglobin in Pragathi Enclave, Hyderabad | Dengue NS1 Antigen - Elisa in Pragathi Enclave, Hyderabad | Complete Urine Examination in Pragathi Enclave, Hyderabad | Glucose, Post Prandial (PP), 2 Hours (Post Meal) in Pragathi Enclave, Hyderabad | Lipid Profile in Pragathi Enclave, Hyderabad | Liver Function Test (LFT) in Pragathi Enclave, Hyderabad | Thyroid Profile (Total T3, Total T4, TSH) in Pragathi Enclave, Hyderabad | Thyroid Stimulating Hormone (TSH), Serum in Pragathi Enclave, Hyderabad | C - Reactive Protein CRP (Quantitative) in Pragathi Enclave, Hyderabad | Creatinine, Serum in Pragathi Enclave, Hyderabad | Platelet Count in Pragathi Enclave, Hyderabad | Culture And Sensitivity Urine in Pragathi Enclave, Hyderabad | Peripheral Smear For Malarial Parasite (MP) in Pragathi Enclave, Hyderabad | Renal Profile/Renal Function Test (RFT/KFT) in Pragathi Enclave, Hyderabad | Widal Test ( Slide Method ) in Pragathi Enclave, Hyderabad | Glucose, Random in Pragathi Enclave, Hyderabad | Dengue Profile - Elisa in Pragathi Enclave, Hyderabad | Uric Acid - Serum in Pragathi Enclave, Hyderabad | Erythrocyte Sedimentation Rate (ESR) in Pragathi Enclave, Hyderabad | Total Beta - HCG (TB-HCG) in Pragathi Enclave, Hyderabad | Hemoglobin in Pragathi Enclave, Hyderabad | Hemogram in Pragathi Enclave, Hyderabad | Electrolytes - Serum in Pragathi Enclave, Hyderabad | Vitamin B12 in Pragathi Enclave, Hyderabad | Prothrombin Time (PT/INR) in Pragathi Enclave, Hyderabad | Potassium - Serum / Plasma in Pragathi Enclave, Hyderabad | Thyroid Profile - Free (FT3, FT4, TSH) in Pragathi Enclave, Hyderabad | Urea And Creatinine in Pragathi Enclave, Hyderabad | Sodium - Serum in Pragathi Enclave, Hyderabad | Vitamin D - 25 Hydroxy (D2+D3) in Pragathi Enclave, Hyderabad | Blood Group ABO And RH Factor in Pragathi Enclave, Hyderabad | Dengue Fever NS1 Antigen, Rapid in Pragathi Enclave, Hyderabad | Hiv Rapid in Pragathi Enclave, Hyderabad

Anti-Dsg-I (Pemphigus Foliaceus) near you

Anti-Dsg-I (Pemphigus Foliaceus) in Beeramguda | Anti-Dsg-I (Pemphigus Foliaceus) in Begumpet | Anti-Dsg-I (Pemphigus Foliaceus) in Kondapur Junction | Anti-Dsg-I (Pemphigus Foliaceus) in Kondapur | Anti-Dsg-I (Pemphigus Foliaceus) in Kukatpally Housing Board Colony | Anti-Dsg-I (Pemphigus Foliaceus) in Kukatpally Metro Parking | Anti-Dsg-I (Pemphigus Foliaceus) in Lingampally | Anti-Dsg-I (Pemphigus Foliaceus) in Madhapur | Anti-Dsg-I (Pemphigus Foliaceus) in Manikonda | Anti-Dsg-I (Pemphigus Foliaceus) in Miyapur | Anti-Dsg-I (Pemphigus Foliaceus) in My Home Jewel Road | Anti-Dsg-I (Pemphigus Foliaceus) in Nizampet | Anti-Dsg-I (Pemphigus Foliaceus) in Sri Lakshmi Residency | Anti-Dsg-I (Pemphigus Foliaceus) in Malkajgiri | Anti-Dsg-I (Pemphigus Foliaceus) in Gachibowli | Anti-Dsg-I (Pemphigus Foliaceus) in Gopanapalli | Anti-Dsg-I (Pemphigus Foliaceus) in Jagadgiri Gutta | Anti-Dsg-I (Pemphigus Foliaceus) in Kanaka Durga Temple | Anti-Dsg-I (Pemphigus Foliaceus) in Masjid Banda | Anti-Dsg-I (Pemphigus Foliaceus) in Mayuri Nagar Welfare Association | Anti-Dsg-I (Pemphigus Foliaceus) in Palm Breeze Rd | Anti-Dsg-I (Pemphigus Foliaceus) in Pragathi Enclave | Anti-Dsg-I (Pemphigus Foliaceus) in Rtc Colony | Anti-Dsg-I (Pemphigus Foliaceus) in Kothaguda X Road | Anti-Dsg-I (Pemphigus Foliaceus) in Rethibowli | Anti-Dsg-I (Pemphigus Foliaceus) in Banjara Hills | Anti-Dsg-I (Pemphigus Foliaceus) in Borabanda | Anti-Dsg-I (Pemphigus Foliaceus) in Kukatpally | Anti-Dsg-I (Pemphigus Foliaceus) in Hitech City | Anti-Dsg-I (Pemphigus Foliaceus) in Bhaskar Nagar | Anti-Dsg-I (Pemphigus Foliaceus) in Manikonda | Anti-Dsg-I (Pemphigus Foliaceus) in Balanagar Township | Anti-Dsg-I (Pemphigus Foliaceus) in Hmt Township | Anti-Dsg-I (Pemphigus Foliaceus) in Nizampet | Anti-Dsg-I (Pemphigus Foliaceus) in Administrative Buildings | Anti-Dsg-I (Pemphigus Foliaceus) in Amberpet | Anti-Dsg-I (Pemphigus Foliaceus) in Attapur | Anti-Dsg-I (Pemphigus Foliaceus) in Central Secretariat | Anti-Dsg-I (Pemphigus Foliaceus) in Dattatreya Colony | Anti-Dsg-I (Pemphigus Foliaceus) in Falaknuma | Anti-Dsg-I (Pemphigus Foliaceus) in Hasannagar | Anti-Dsg-I (Pemphigus Foliaceus) in I.e.nacharam | Anti-Dsg-I (Pemphigus Foliaceus) in Jubilee Hills | Anti-Dsg-I (Pemphigus Foliaceus) in Malakpet Colony | Anti-Dsg-I (Pemphigus Foliaceus) in Raj Bhawan | Anti-Dsg-I (Pemphigus Foliaceus) in Sitaphalmandi | Anti-Dsg-I (Pemphigus Foliaceus) in Cuc | Anti-Dsg-I (Pemphigus Foliaceus) in Manuu | Anti-Dsg-I (Pemphigus Foliaceus) in Bowenpally

Popular tests in Pragathi Enclave, Hyderabad

Urea And Creatinine in Pragathi Enclave, Hyderabad | Sodium - Serum in Pragathi Enclave, Hyderabad | Electrolytes - Serum in Pragathi Enclave, Hyderabad | Blood Group ABO And RH Factor in Pragathi Enclave, Hyderabad | Thyroid Profile - Free (FT3, FT4, TSH) in Pragathi Enclave, Hyderabad | Hiv Rapid in Pragathi Enclave, Hyderabad | Hemogram in Pragathi Enclave, Hyderabad | Ferritin in Pragathi Enclave, Hyderabad | 25-Hydroxy Vitamin D (D2+D3) in Pragathi Enclave, Hyderabad | SGPT/ALT (Alanine Aminotransferase) in Pragathi Enclave, Hyderabad | Widal Test ( Slide Method ) in Pragathi Enclave, Hyderabad | Calcium - Serum in Pragathi Enclave, Hyderabad | HBsAg Screening - Rapid in Pragathi Enclave, Hyderabad | Testosterone (TOTAL) in Pragathi Enclave, Hyderabad | Cholesterol - Serum in Pragathi Enclave, Hyderabad | Peripheral Smear For Malarial Parasite (MP) in Pragathi Enclave, Hyderabad | Apollo Basic Hormone Check in Pragathi Enclave, Hyderabad | Dengue NS1 Antigen - Elisa in Pragathi Enclave, Hyderabad | Prolactin in Pragathi Enclave, Hyderabad | VDRL (RPR) in Pragathi Enclave, Hyderabad

Popular packages in Pragathi Enclave, Hyderabad

Apollo Womens Health - Essential in Pragathi Enclave, Hyderabad | Apollo Vitamin Check - Advance in Pragathi Enclave, Hyderabad | Apollo Womens Health - Basic in Pragathi Enclave, Hyderabad | Apollo Thyroid Assessment - Essential in Pragathi Enclave, Hyderabad | Apollo PCOD Basic in Pragathi Enclave, Hyderabad | Apollo Kidney Check - Basic in Pragathi Enclave, Hyderabad | Apollo Fever Panel - Essential in Pragathi Enclave, Hyderabad | Essential Panel (Heart, Liver, Kidney and Sugar) in Pragathi Enclave, Hyderabad | Apollo Vitamin Check - Essential in Pragathi Enclave, Hyderabad | Apollo Vitamin Check in Pragathi Enclave, Hyderabad | Apollo Full Body Check - Advance I in Pragathi Enclave, Hyderabad | Apollo Hairfall Check Advance Male in Pragathi Enclave, Hyderabad | Apollo Kidney Check - Advance in Pragathi Enclave, Hyderabad | Apollo Hairfall Check Advance Female in Pragathi Enclave, Hyderabad | Apollo Senior Citizens Care Female - Advance in Pragathi Enclave, Hyderabad | Apollo Diabetes Panel - Advance Male in Pragathi Enclave, Hyderabad | Apollo PCOD Comprehensive in Pragathi Enclave, Hyderabad | Apollo Womens Health - Advance in Pragathi Enclave, Hyderabad | Free And Total Thyroid Profile (T3,T4, FT3, FT4,TSH) in Pragathi Enclave, Hyderabad | Holistic Health Check for Women in Pragathi Enclave, Hyderabad

Why should Apollo be your preferred healthcare partner?

  • 40 Years of legacy and credibility in the healthcare industry.
  • NABL certified multi-channel digital healthcare platform.
  • Affordable diagnostic solutions with timely and accurate test results.
  • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
  • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results