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Anti Saccharomyces Cerevisiae Antibody (ASCA) IgG

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  • ANTI SACCHAROMYCES CEREVISIAE ANTIBODY (ASCA) IGG

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About

blood sample
Sample

BLOOD

Gender
Gender

Both

users
Age group

7 years & above

People with inflammatory bowel disease (IBD) have immunological proteins called anti-saccharomyces cerevisiae antibodies (ASCA). The ASCA IgG and IgA test detects anti-saccharomyces cerevisiae antibodies in the bloodstream.

An inflammatory bowel disease is a group of chronic illnesses, including intestinal lining erosion and swelling that an autoimmune disease could cause. IBD clinical manifestations can change over time and vary considerably.

Many impacted people go through flare-ups, followed by intervals of symptomatic relief or even relapse. Inflammatory bowel disease has two primary forms: 

  • Crohn's disease (CD)
  • Ulcerative colitis (UC)

While ulcerative colitis arises in the colon, Crohn's disease can impact any area of the gastrointestinal tract, including the mouth and the anus.

Faecal calprotectin can be utilised to distinguish inflammatory bowel disease from non-inflammatory illnesses like irritable bowel syndrome since Crohn's disease and ulcerative colitis are both marked by gastrointestinal inflammation. To rule out inflammatory bowel disease as a diagnosis and eliminate unwanted endoscopic or imaging treatments, faecal calprotectin is helpful.

The analysis of biopsy samples taken from the bowels and endoscopic examinations are used to determine the prognosis of Crohn's disease or ulcerative colitis. Even with biopsies, distinguishing between Crohn's disease and ulcerative colitis can occasionally be challenging because both can be detected in the colon.

When this happens, ASCA screening may be beneficial because Crohn's disease patients are considerably more likely to have anti-saccharomyces cerevisiae antibodies than ulcerative colitis patients.

The body produces anti-saccharomyces cerevisiae antibodies IgG and IgA against Saccharomyces cerevisiae. Typically, both classes are tested. The intensity of the condition and the requirement for operations as a therapy option may be predicted by the anti-saccharomyces cerevisiae antibody IgG.

In individuals with inflammatory bowel disease, this test is ineffective for assessing disease severity or monitoring the effectiveness of disease-specific treatments, such as surgical removal of the affected intestine.

At Apollo 24|7, anti-saccharomyces cerevisiae immunoglobulin A titers are tested using a licensed microtiter enzyme assay performed as follows:

  • S. cerevisiae that has been partially filtered and fragmented adheres to the reservoirs of a polystyrene plate containing isolated mannan extracted from S. cerevisiae's cell membrane. 
  • To allow the anti-saccharomyces cerevisiae antibodies to attach to the immobilised antigen, pre-diluted standards and diluted patient samples are introduced to independent wells. 
  • An HRP-conjugated anti-human IgA antibody is then applied to each cell after the free sample has been removed. 
  • The enzyme-marked anti-human IgA must undergo a second incubation to attach to any patient antibody that has managed to adhere to the microtiter wells. 
  • The residual enzyme activity is measured by introducing chromogenic substrates and observing the intensity of the colour that forms after removing any unbound enzyme identified with anti-human IgA.

The test is assessed by measuring and comparing the colour intensity in the patient wells with the colour in the control wells. Relative units per millilitre (RU/mL) are used to express the test results of ASCA IgA.
 

faqFrequently Asked Questions (FAQs)

When is Anti-Saccharomyces Cerevisiae Antibody (ASCA) IgG and IgA ordered?

When a patient exhibits symptoms and signs of inflammatory bowel disease and a doctor wants to differentiate between Crohn's disease and ulcerative colitis, ASCA testing is generally prescribed. The signs and symptoms of inflammatory bowel disease may include: Cramping and discomfort in the abdomen Diarrhoea Bleeding Fever Musculoskeletal and organ-related complaints, including fatigue Impaired maturation and growth retardation in children

What does the test's outcome indicate?

Positive ASCA results do not rule out the possibility of Crohn's disease and ulcerative colitis; however, they increase the likelihood that a patient with signs has an inflammatory bowel disease. ASCA test results are frequently evaluated in combination with p-ANCA test findings: It is most likely that someone has Crohn's disease if their ASCA is positive and their p-ANCA is negative. When p-ANCA is positive and ASCA is negative, ulcerative colitis is most likely the diagnosis. Inflammatory bowel disease is not automatically ruled out if ASCA and p-ANCA results are negative. Even if the test results are negative, a person may have Crohn's disease, ulcerative colitis, or inflammatory bowel disease.

When can I expect to get my results?

Not all hospital laboratories provide ASCA testing. Your blood sample may need to be sent to a standard laboratory for analysis, and it could take a day or more for the results to be ready.

Does ASCA testing need to be done more than once?

To differentiate between Crohn's disease and ulcerative colitis, testing is typically done only once. It is customary to simultaneously order tests for both IgG and IgA categories of anti-saccharomyces cerevisiae antibodies.

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The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results