Apolipoprotein- A1

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    blood sample




    Age group

    Above 10 years

    The human body contains biochemical substances (lipoproteins) that carry cholesterol through the bloodstream. The two primary types of cholesterol are as follows:

    • High-Density Lipoproteins (HDL)
    • Low-Density Lipoproteins (LDL)

    Apolipoprotein A1 (APO A1) is the primary protein component in HDL. APO A1 helps remove excess cholesterol from peripheral tissues and subsequently delivers that cholesterol to the liver. The protein also regulates cholesterol levels present in cells.

    Consequently, low APO A1 levels can increase the risk of cardiovascular diseases (CVD) such as the following:

    • Coronary heart disease 
    • Strokes 
    • Peripheral artery diseases 
    • Aortic valve diseases

    It’s essential to note that decreased APO A1 levels are not solely responsible for an individual developing CVD. Some other risk factors include:

    • Unhealthy diet
    • Physical inactivity
    • Excessive consumption of tobacco products or alcohol
    • Hypertension
    • Diabetes

    Individuals engaging excessively with the listed behavioural patterns may experience increased blood pressure levels, high blood glucose levels and obesity. These symptoms indicate an increased risk for CVD but do not necessarily mean that the individual will develop the condition.

    Remedial actions addressing the behavioural patterns can significantly reduce the associated risks for the disease. However, in cases of hypertension and diabetes, drug treatment is necessary to minimize cardiovascular risk.

    The Apolipoprotein A1 test (APO A1 test) assesses APO A1 levels to determine the probability of a person developing CVD. The assessment is part of a more extensive CVD testing process. While decreased APO A1 levels associate with increased cardiovascular risk, apolipoprotein B (APO B) also plays a significant role.

    APO B is a primary component in LDL, and elevated levels of the same may act as a trigger for cardiovascular issues. Consequently, an APO A1 test should be supplemented with assessment of APO B levels to screen for CVD thoroughly.

    For the APO A1 test, anti-apolipoprotein A1 antibodies combine with a controlled antigen. The reaction between the two substances eventually agglutinates (particles clumping together due to a serological response). A turbidimeter assesses the final complex by measuring the loss of light intensity when passing through the particulate matter.

    The normal APO A1 ranges differ based on factors such as age and gender. For adult males, anything slightly above or equal to 120 mg/dL is an acceptable level. In the case of adult females, the normal range sits at 140 mg/dL or slightly higher.

    Deficient APO A1 levels (less than 20 mg/dL) imply an existing liver disease or a genetic disorder. In rare cases, gammopathy (the presence of abnormal proteins in the blood) may produce a false test result.

    Apollo 24|7 offers an Apolipoprotein A1 test that can comprehensively evaluate APO A1 levels in an individual. In addition to assessing cardiovascular risk, the results of such tests can help in the following: 

    • Conducting sequential studies for individuals with inconsistent lipid measures 
    • Supplementing studies that examine cardiovascular risk factors associated with family history

    packageTop Tests with Apolipoprotein- A1

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    Specific medications or conditions can lead to elevated apolipoprotein A1 levels. Some examples include:  Drugs like carbamazepine, niacin and estrogenic supplements Pregnancy Oral contraceptives Weight loss Increased physical activity Medications that lower LDL levels, such as lovastatin or simvastatin
    Apolipoprotein A1 is the primary protein found in HDL, which reduces the probability of cardiovascular complications when present at normal levels. Optimum levels of the protein point to normal HDL levels. It’s important to note that APO A1 levels can also increase independent of HDL concentrations.
    The factors associated with decreased APO A1 levels include:  Smoking Obesity Chronic kidney or liver diseases Unmanaged diabetic symptoms Drugs like androgens, diuretics and beta blockers progestins Diets that include high amounts of carbohydrates and unsaturated fats
    Genetic factors often determine APO A1 levels. Regardless, to reduce the risk of CVD, individuals can take the following steps: Adopt a healthier diet that includes lean meat, fish, vegetable and whole grains Engage in regular exercise Maintain an average body mass index (BMI)
    Alongside the APO A1 test, most doctors recommend taking the tests listed below: Lipid profile test APO B test These tests enable doctors to assess an individual's cardiovascular risk accurately.
    Blood samples for the test are collected through a tiny prick on the subject’s finger. Hence, there are no commonly associated risks. In rare cases, an individual might feel lightheaded or dizzy due to blood collection. During such situations, a doctor can prescribe any necessary medication.

    Why should Apollo be your preferred healthcare partner?

    • 40 Years of legacy and credibility in the healthcare industry.
    • NABL certified multi-channel digital healthcare platform.
    • Affordable diagnostic solutions with timely and accurate test results.
    • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
    • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results