CELIAC DISEASE PROFILE COMPREHENSIVE (GLIADIN AB.IGG AND IGA,TTG IGA,ENDOMYSIAL IGA) in Falaknuma, Hyderabad

Celiac Disease Profile Comprehensive (Gliadin Ab IgA/IgG, tTG IgA, Endomysial IgA): Price, Purpose, Range & Reports

Celiac disease is a chronic autoimmune disorder triggered by the consumption of gluten (a protein found in wheat, barley, and rye). In genetically susceptible individuals, gluten ingestion leads to damage in the small intestine, impairing nutrient absorption and causing a wide range of gastrointestinal and systemic symptoms.

The Celiac Disease Profile Comprehensive is a specialised blood test designed to simultaneously screen for and confirm the presence of the key autoantibodies associated with celiac disease. By testing for multiple markers (including Tissue Transglutaminase (tTG) IgA, Endomysial Antibodies (EMA) IgA, and Deamidated Gliadin Peptide (DGP) IgA and IgG), this panel offers high diagnostic accuracy. If you are looking for the Celiac Disease Profile Comprehensive price or a reliable lab near me, Apollo 24|7 provides advanced, accredited testing for autoimmune conditions.

What is the Celiac Disease Profile Comprehensive Test?

The Celiac Profile Test is a comprehensive blood panel used to screen for and support the diagnosis of celiac disease, an autoimmune condition triggered by gluten. This test measures specific antibodies that the immune system produces in response to gluten exposure, including anti-Gliadin IgA and IgG, anti-tissue transglutaminase (tTG) IgA, and anti-Endomysial IgA.

Together, these markers help detect immune activity against gluten and assess intestinal damage. The test is typically recommended for individuals with symptoms such as chronic diarrhoea, abdominal pain, bloating, fatigue, or unexplained nutrient deficiencies. It is also useful for those with a family history of celiac disease or associated autoimmune disorders.

What is the Celiac Profile Test Price?

The Celiac Profile Test price is representative of the specialised multi-component immunoassay panel used to accurately screen for Celiac Disease. The final cost of your test is influenced by several elements:

•    Technology Used: The test relies on accurate Enzyme-Linked Immunosorbent Assay (ELISA) technology to measure multiple distinct antibodies (IgA and IgG), which contributes to the precision and value of the profile.
•    Location: Prices may differ slightly between cities and regions due to variances in local operating costs and logistical factors.
•    Lab Accreditation: Tests conducted at accredited laboratories, such as those operated by Apollo, ensure adherence to high-quality standards, which are vital for reliable autoimmune screening results.

If you're trying to find the most accurate and affordable Celiac Profile Test price near me, the easiest way is to check the Apollo 24|7 website or app. They update prices regularly based on your location, so you’ll always see the latest rates and any available offers.

What is the Purpose of the Celiac Disease Profile Comprehensive?

The primary purpose of this panel is the accurate diagnosis and differential diagnosis of gluten-related disorders:

1.    Primary Diagnosis: To confirm celiac disease in individuals exhibiting classic or non-classic symptoms.
2.    Screening: To screen high-risk groups, such as first-degree relatives of celiac patients, or individuals with associated conditions (e.g., Type 1 Diabetes, Down syndrome, or Hashimoto’s thyroiditis).
3.    Evaluating IgA Deficiency: The inclusion of DGP IgG ensures that celiac disease is not missed in patients with selective IgA deficiency, a common co-existing condition that can lead to false-negative IgA results.
4.    Monitoring Compliance: While primarily used for diagnosis, IgA antibody levels (especially tTG IgA) are also sometimes used to monitor adherence to a gluten-free diet (levels should decrease upon successful adherence).

Who Should Get a Celiac Disease Profile Comprehensive Done?

A doctor will typically recommend this comprehensive profile for individuals presenting with symptoms suggestive of celiac disease or who belong to high-risk categories:

•    Gastrointestinal Symptoms: Chronic diarrhoea, severe abdominal pain, bloating, gas, or unexplained weight loss.
•    Malabsorption Symptoms: Iron deficiency anaemia, Vitamin D deficiency, easy bruising, or bone/joint pain due to poor nutrient absorption.
•    Non-GI Symptoms: Persistent fatigue, recurrent mouth ulcers, skin rashes (Dermatitis Herpetiformis), or fertility problems.
•    High-Risk Individuals: Anyone with a first-degree relative (parent, sibling, child) diagnosed with celiac disease, or those with associated autoimmune disorders (especially Type 1 Diabetes and Autoimmune Thyroid Disease).
•    Children: Children experiencing growth failure, delayed puberty, chronic constipation, or vomiting.

Components of the Celiac Disease Profile Comprehensive Panel 

The Celiac Disease Profile Comprehensive Panel is a diagnostic blood test used to evaluate immune responses associated with celiac disease, an autoimmune condition triggered by gluten ingestion. This panel includes multiple serologic markers that help identify both active disease and underlying immune sensitivity to gluten.

Key Components

1.    Tissue Transglutaminase (tTG) IgA: This is the most sensitive and specific marker for celiac disease. It detects IgA antibodies directed against the tissue transglutaminase enzyme, which plays a role in intestinal repair. Elevated levels are strongly associated with gluten-induced damage to the small intestine.
2.    Deamidated Gliadin Peptide (DGP) Antibodies – IgA and IgG: These antibodies target modified fragments of gliadin, a component of gluten.
o    DGP IgA is useful in identifying early immune responses.
o    DGP IgG is particularly important in individuals with IgA deficiency, where IgA-based tests may be unreliable.
3.    Endomysial Antibodies (EMA) IgA: EMA IgA targets the endomysium, a connective tissue surrounding intestinal muscle fibres. It is highly specific for celiac disease and is often used to confirm a positive tTG IgA result.

Understanding the Measured Components and Report

Results from this panel are reported as either quantitative values (for tTG and DGP) or qualitative outcomes (positive, negative, or indeterminate for EMA). Interpretation depends on whether the measured values exceed the established upper limit of normal (ULN). Here's how each marker is typically assessed:

Important Note

•    Positive serologic results (especially elevated tTG IgA and EMA IgA) are highly suggestive of celiac disease. However, confirmation through small intestine biopsy via endoscopy is still considered the gold standard, particularly in adults.
•    Negative results, when the patient is actively consuming gluten, generally rule out active celiac disease. However, if the patient is on a gluten-free diet at the time of testing, results may be falsely negative, and further evaluation may be needed.
•    Clinical interpretation should always be made by a qualified healthcare provider, taking into account the patient’s symptoms, dietary history, family history, and other relevant findings.

Preparation and Procedure for Celiac Disease Profile Comprehensive

The testing procedure is simple, but the preparation regarding diet is critical.

Is Fasting Required?

No, fasting is not required for the Celiac Disease Profile Comprehensive. You may eat and drink normally before the blood draw.

Dietary Requirement (CRITICAL)

The most important pre-test requirement is the Gluten Challenge. To ensure the immune system is producing the autoantibodies, the patient must be consuming a diet containing gluten (equivalent to about four slices of bread per day) for at least 4-6 weeks prior to the test.

Should I Tell My Doctor About My Medications?

Always inform your doctor about all current medications and supplements. However, these specific antibody levels are not typically affected by common medications, making the test robust against drug interference.

How is the Test Done?

The test requires a standard peripheral venipuncture (blood draw).
1.    A phlebotomist will clean a site on your arm, usually in the crook of the elbow.
2.    A small sample of venous blood is collected into a tube.
3.    The sample is then sent to the laboratory for assay testing to determine the concentration of the four specific antibodies.

What Time of Day Should I Take the Test?

The test can be collected at any time during the laboratory’s operating hours, as antibody levels do not fluctuate based on the time of day.

How Often Do I Need This Test?

This test is generally performed once for diagnosis. If the result is negative but symptoms persist, or if the patient was not adequately exposed to gluten prior to the test, a retest might be recommended. Once a diagnosis is confirmed, the test is not repeated unless monitoring compliance is requested by a physician.

Booking Celiac Disease Profile Comprehensive Online & Checking Reports

Apollo 24|7 offers a seamless process for scheduling this important test and accessing your results.

A. How to Schedule the Test on Apollo 24|7

•    Visit the Apollo 24|7 platform and search for the Celiac Disease Profile Comprehensive.
•    Review the latest price for your location and click 'Book Now'.
•    Select a convenient date and time for the sample collection.
•    Complete the secure online payment to confirm your booking.

B. How to Access Your Test Results Online

•    Log in to your Apollo 24|7 account via the website or mobile app.
•    Navigate to the 'Health Records' or 'My Reports' section.
•    Click on the completed Celiac Disease Profile report.
•    You can view and download the detailed report in PDF format.

 Conclusion

The Celiac Disease Profile Comprehensive provides a robust, multi-marker approach to diagnosing celiac disease. By strategically combining the highly sensitive tTG IgA with the highly specific EMA IgA and the versatile DGP antibodies, this panel minimises the risk of missed diagnosis, especially in IgA-deficient patients. This clarity is essential for initiating a lifelong, medically necessary gluten-free diet and managing the long-term health complications of this autoimmune condition.