Ceruloplasmin - Serum

Ceruloplasmin is a protein in the human body responsible for storing and carrying mineral copper around the body. Usually, the liver transfers the liver from the bloodstream to the ceruloplasmin, which helps transport it to the other tissues. Copper is vital for the body, helping promote strong bones and producing melanin. However, too much copper in the blood can be toxic and lead to health complications.

The presence of excessive copper in the body may lead to a condition called Wilson's disease. It leads to the build-up of copper around the liver, brain, and other vital organs. The disorder can be credited to copper toxicity, where the body cannot eliminate it effectively.

Wilson's disease is a life-threatening condition that might lead to severe irreversible consequences.These are:

• Liver cirrhosis, leading to the formation of scars in the organ that make it difficult for it to function
• Acute liver failure that might occur gradually
• Neurological issues like involuntary muscle movements and speech difficulties
• Numerous kidney issues, like the formation of kidney stones and abnormal levels of amino acids in the urine

The ceruloplasmin-serum test is a diagnostic test to detect the amount of copper in the ceruloplasmin and hence, aid in detecting Wilson's disease. During this condition, the liver cannot transfer the copper to ceruloplasmin, leading to an unhealthy copper accumulation. Wilson's disease also prevents copper from being excreted by the body. The doctor may recommend this test if you have a history of Wilson's disease or nerve and liver-related problems.

It is a standard blood test where the clinical lab technician draws blood from the vein in your arm. This blood is then stored and sent for checking, where the serum undergoes analysis to determine the ceruloplasmin levels in the body. If the results are in the range of 20 to 35 milligrams per litre (mg/L), the patient has normal levels of this protein. However, lower readings (< 10 mg/L) may increase the likelihood of having Wilson's disease. Low ceruloplasmin levels may also cause nephrotic syndrome, kidney problems and problems with absorbing nutrients.

Apollo 24/7 offers a comprehensive ceruloplasmin-serum test to detect abnormal levels of protein accumulated in the body. Some of the symptoms of copper toxicity may include:

• Trouble speaking or swallowing
• Tremors
• Lack of coordination
• Stiff muscles
• Changes in behaviour
• Swollen liver or spleen
• A build-up of fluid in the legs and belly
• Yellowing of the skin and eyes (jaundice)
• Anaemia
• Low platelet or white blood cell count
• Slow blood clotting

If these symptoms are persistent, it is vital to consult a health practitioner before the patient's condition worsens. The patient should also avoid consuming copper-rich foods like shellfish, mushrooms, nuts, or chocolate.