Coombs Test (Indirect) in Chennai

Test Overview

Overview of the Coombs Test (Indirect) in Chennai

The Coombs test (indirect), also known as the indirect antiglobulin test (IAT), is a blood test that detects the presence of antibodies in the serum that could potentially react with red blood cells. These antibodies are produced by the immune system in response to foreign red blood cells, such as those from a different blood type or during pregnancy. The test helps identify whether these antibodies are present, which is crucial in preventing adverse reactions during blood transfusions and managing pregnancies to protect the foetus from maternal antibodies. The Coombs test (indirect) in Chennai is a valuable tool for ensuring safe blood transfusions and monitoring maternal-foetal compatibility.

Apollo offers a Coombs Test (Indirect) test across many cities such as:

You can also download the Apollo 24|7 App for a better experience.

Tests Included in Coombs Test (Indirect) 

The Coombs test (indirect) is a single test rather than a package of multiple tests, but it can be part of a broader set of tests used in immunohematology.

• Coombs Test (Indirect): The test involves isolating the serum from a blood sample and incubating it with non-patient RBCs of known antigenicity. Anti-human globulin (Coombs reagent) is then added to the mixture. If agglutination (clumping of RBCs) occurs, the test is positive, indicating the presence of antibodies against the RBCs.

The optional test includes:

• Titre: Depending on the results, additional tests may be conducted to identify the specific type of antibody present and its clinical significance. These can include antibody identification, RBC phenotyping, and titration studies to determine the concentration of the antibodies.

What Treatments/Procedures can Require the Coombs Test (Indirect)?

The indirect Coombs test is used in several medical contexts to guide treatment and management. Here are some medical treatments and procedures that may require this test:

• Blood Transfusions: Before a blood transfusion, the indirect Coombs test is performed to check for any antibodies in the recipient’s blood that could react with the donor's blood. This helps prevent hemolytic transfusion reactions.
• Management of Hemolytic Disease of the Newborn (HDN): In pregnant women, especially those who are Rh-negative, the test is done to assess the risk of HDN due to maternal antibodies. If antibodies are detected, closer monitoring and potential interventions (like intrauterine transfusions or early delivery) may be needed.
• Treatment of Autoimmune Hemolytic Anemia: While the direct Coombs test is more commonly used for diagnosing autoimmune hemolytic anaemia, the indirect test can help in identifying the specific antibodies involved, guiding treatment decisions like corticosteroids or immunosuppressive therapies.
• Evaluation for Organ Transplantation: Before organ transplantation, the indirect Coombs test can be part of the compatibility testing to ensure that the recipient does not have antibodies that could attack the donor organ.
• Fertility Treatments: In cases of assisted reproductive technologies (ART), the indirect Coombs test may be performed to check for Rh incompatibility between the mother and potential donor sperm, particularly if the mother is Rh-negative.
• Preoperative Assessment: In patients with known hemolytic anaemia or those at risk of hemolysis, the test may be conducted before surgery to evaluate potential transfusion needs and avoid complications.

Coombs Test (Indirect) Requirements in Chennai

To undergo the indirect Coombs test in Chennai, there are a few requirements to keep in mind:

• There are no specific dietary requirements or preparations needed for the Coombs test (indirect).
• A phlebotomist will collect a blood sample from a vein in the arm or hand using a needle. The process involves a small skin prick and may result in minor bleeding or bruising at the needle insertion site.
• The blood sample is then sent to a laboratory for analysis.

Price of the Coombs Test (Indirect) in Chennai

The indirect Coombs test price in Chennai can vary depending on the doctor and the specific laboratory. Factors such as the location of the facility, the equipment used, and the expertise of the staff can all contribute to the final cost. On average, the Coombs test price in Chennai ranges from Rs____ to Rs_____.

Reports of the Coombs Test (Indirect)

The Coombs test (indirect) report typically presents the results as either positive or negative:

Note: The interpretation of these results can vary depending on the laboratory, age, sex, and underlying conditions.

How Often Should You be Recommended the Coombs Test (Indirect)?

The frequency of the indirect Coombs test depends on specific circumstances and clinical guidelines. Here are some general recommendations for when the test is performed:

• Pregnant Women: The test is typically done during the first prenatal visit (usually in the first trimester) to check for Rh incompatibility and other antibodies. A follow-up test is often performed in the third trimester (around 28 weeks) to identify any new antibodies that may develop as the pregnancy progresses.
• Blood Donors: The test is conducted at the time of blood donation as part of routine screening to ensure the safety of the blood supply.
• Patients Preparing for Blood Transfusion: The test is performed whenever a patient is scheduled for a blood transfusion to assess compatibility with donor blood. This is generally done for each transfusion.
• Individuals with Autoimmune Disorders or Hemolytic Anemia: The test may be recommended periodically based on clinical findings and the patient's condition, rather than on a regular schedule. The frequency can vary based on the stability of the condition and any changes in symptoms.
• Neonates: Newborns suspected of having hemolytic disease are typically tested shortly after birth, especially if the mother is known to have antibodies.

Book a Coombs Test (Indirect) Online

Booking a Coombs test in Chennai through Apollo 24|7 is a simple and convenient process that can be completed online. Here's a step-by-step guide:

• Visit the Apollo 24|7 website or download the app on your smartphone.
• Use the search function to find "Coombs Test (Indirect) in Chennai" or "Indirect Coombs Test in Chennai".
• Select a suitable time slot and location for your blood sample collection.
• Complete the booking process by providing the necessary details and making the payment.
• Wait for a confirmation message from Apollo 24|7 regarding your indirect Coombs test in Chennai.