SRY Testing By Fish

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    blood sample




    Age group

    Above 10 years

    The Sex Determining Region Y (SRY) gene codes for a protein responsible for developing male characteristics in the foetus. This gene is present on the Y chromosome and helps find gender differentiation abnormalities in the foetus.

    SRY testing by Fluorescence In-Situ Hybridisation (FISH) method determines the deletion or mislocation of this gene. Abnormalities in the SRY gene test can give insights about the abnormal gene in parents.

    Gender differentiation abnormalities can lead to various problems in a child since the issue occurs at the genetic level. Early diagnosis can help prepare for the condition and take the necessary steps.

    The FISH technique is an accurate methodology for genetic tests. Many paediatricians and genetic counsellors order complete karyotyping that determines the structure of each chromosome present in the individual. A paediatrician can also advise microarray testing as an alternative to SRY gene test and karyotyping for detailed information.

    The SRY protein has a specific pattern in every individual, and it is responsible for the development of male gonads. Also, the gene prevents the development of female characteristics in the foetus. This gene is also known as the testis-determining factor.

    Who Should Get Tested?

    This routine test allows the parents and pregnant woman to understand if the baby has any genetic disorder related to gender differentiation. It can detect Swyer syndrome, testicular development disorder, and other problems like gene translocation.

    The displacement of the gene to an X chromosome causes the ovotesticular disorder. To manage such rare conditions effectively, early diagnosis is essential. There are several treatments like hormone therapy and psychological counselling available for such patients. 

    Medically reviewed by Dr. Sushmita Prakash, Obstetrics and Gynaecology, Apollo Hospitals Sector 26, Noida

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    No, there are no such risks associated with SRI testing. The test uses a blood sample, which is extracted with a needle in your vein. Hence, you might experience some light scarring or bleeding at the point of contact with the needle.
    If the SRY gene hasn't been activated, there won't be a functional sex-determining region Y protein. As a result, the unborn fetus won't develop testes.  However, it will develop fallopian tubes and a uterus. This will happen even if the fetus has both the X and Y chromosome.
    The SRY gene is a male-typical sex development protein responsible for testes' growth. In case this gene mutates, you will experience a 46, XX testicular disorder of sex development. You will now have male sex characteristics (i.e., testes) paired with a female-typical chromosome pattern (testes may be small and undescended).
    The SRY gene, or the Sex-determining Region Y, is found on the Y chromosome. This chromosome helps in the development of male phenotypes (testes). The gene can be found on a short branch of the Y chromosome and plays a critical role in male embryonic development in the XY sex-determination system.
    the SRY gene becomes active 6-8 weeks post fetus formation. This gene prevents female anatomical structure growth in males and helps develop several dominant male characteristics.
    The SRY gene doesn't directly affect behaviour. However, extensive research found out that since the gene is responsible for the development of high androgens and testes in males, it also contributes to male aggression.

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    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results