CD117 (Myeloid Cell Marker)

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    blood sample




    Age group

    Above 10 years

    The CD117 is a protein that binds to the stem cell factor and aids the growth of specific types of blood cells. It is a type of receptor tyrosine kinase and is usually considered a tumour marker.

    If the amount of CD117 protein in the cells is higher than usual, it might indicate the presence of cancerous cells, melanoma and even gastrointestinal stromal tumour (GIST). These tumours are cancerous and originate in the digestive system. The cancerous growth might not depict any symptoms initially. However, if the tumour worsens and complications increase, one might experience multiple symptoms like:

    • Nausea and vomiting 
    • Abdominal pain 
    • Cramps in the abdomen after eating 
    • Dark-coloured stool 
    • Loss of appetite 
    • Tiredness and fatigue 
    • A feeling of fullness after consuming small quantities of food

    These gastrointestinal tumours are common in adults but can occur in people of all ages.

    In certain cases, CD117 protein can also lead to mast cell disease, where you might experience abnormal growth of mast cells in the intestines and under the skin. Some of the symptoms include:

    • Skin blisters 
    • Stomach pain, vomiting and nausea 
    • Red blotches, bumps or itchy spots on the skin 
    • Bone pain 
    • Low blood pressure

    The best test to diagnose these diseases and treat the symptoms is the CD117 (Myeloid Cell Marker) Test. This test also helps treat similar medical issues like acute myeloid leukaemia and lung carcinoma. Most pathologists use the test to detect gastrointestinal issues and cancerous cells.

    Moreover, doctors use this test to analyse the activity of a cancerous cell, cell type and stage of differentiation. It can help identify hematopoietic progenitors in the bone marrow. CD117 can also depict thymocyte progenitors in the thymus gland.

    Examining the presence of CD117 can also enable doctors to detect prostate stem cells and melanocytes along with the interstitial cells of Cajal. Pathologists can also conduct the test to check if one suffers from intestinal pseudo-obstruction.

    A positive CD117 test result indicates the presence of gastrointestinal stromal tumours. The results help the medical experts initiate treatment processes to stop cancer cell growth.

    During the CD117 (Myeloid Cell Marker) test procedure, the doctors take a blood sample from the vein of your upper arm. Then, they cover the area to stop any bleeding and send the blood sample for examination. If you have any pre-existing conditions like cancer, you should notify the doctor before the test. Also, talk about the medication you might be currently consuming and associated details.

    Apollo 24|7 offers a comprehensive CD117 (Myeloid Cell Marker) test to detect the presence of gastrointestinal stromal tumours. The test also helps diagnose embryonal carcinomas and mast cell disorders. 

    Medically reviewed by Dr.Sanjaya Mishra, Radiation Oncology, Apollo Hospitals Old Sainik School Road, Bhubaneswar.

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    The preparation steps for the CD117 (Myeloid Cell Marker) test are simple. You do not have to modify your diet. However, the doctor might ask you to fast for a certain period before the test. If you have any food allergies or associated complications, discuss them with the doctor beforehand.
    The doctor might put an elastic band on your upper arm to pull the blood easily from the veins. Then, they will collect blood by inserting a needle. They might use a bandage to cover the area to avoid too much bleeding. If you have any bleeding disorders, talk to the doctor before the process begins.
    Gastrointestinal stromal tumours might affect people who are above the age of 50 years. This condition is more common in men. Moreover, the tumour can be genetic, and you might risk developing it if it runs in your family.
    The CD117 protein is called a gastrointestinal stromal tumour marker as it can highlight the presence of GIST in your gastrointestinal tract and surrounding regions. It can also help detect myeloid cells and aid the treatment of conditions like acute myelogenous leukaemia.
    You must seek medical assistance and undergo the CD117 test if you experience severe abdominal pain, dark-coloured stool, fatigue and skin infections. It might indicate the worsening of GIST tumours or mast cell complications.
    You cannot prevent mastocytosis or mast cell disease, as they are genetic. However, if you experience the associated symptoms, consulting a doctor immediately will help in your treatment.

    Why should Apollo be your preferred healthcare partner?

    • 40 Years of legacy and credibility in the healthcare industry.
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    • Affordable diagnostic solutions with timely and accurate test results.
    • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
    • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results