CD5

CD5 is a unique protein that functions as a classifier on the front of distinct types of T-cells as well as a subset of B-cells called B-1a. In the field of haematology and blood topology, the specific functionality and significance of the CD5 protein as a transmitter and differentiator is a contentious topic.

Normal T-lymphocytes are detected using CD5 antibody testing and staining. Most precursor T-cell lymphoblastic lymphomas/leukaemia and mature T-cell non-Hodgkin lymphomas exhibit it at normal or anomalous levels. Some standard B-cell subsets may have low CD5 expression.

CD5 protein expression is also found in various B-cell non-Hodgkin lymphoma subtypes, such as mantle cell lymphoma, chronic lymphoid leukaemia, and, less typically, lymphoplasmacytic lymphomas and marginal zone lymphomas.

The CD5 protein is present on the long arm of the 11th chromosome in humans, and it is thus broadly distributed throughout the body. The protein is extracted via a straightforward CD5 test. CD5 antibody testing usually requires about 2ml of blood, and the same sample can be used for subsequent testing.

A CD5 test is available from Apollo 24|7, and you can acquire the results online from the comfort of your own home. Here are some of the most important things you can do with CD5 antibody testing reports:  

• Help T-cell lymphomas benefit from support for the T-cell lineage 
• Aid in the subdivision of B-cell lymphomas  
• Regularly check your CD5 protein levels to assist your doctor in developing a treatment strategy for your illness
• Learn more about how diet, physical conditioning, exhaustion, and other variables affect your condition by tracking and reporting changes in your CD5 protein levels
   

Frequently asked questions

What is the role of CD5 protein in the body?

CD5 is a T-cell surface glycoprotein that inhibits T-cell Receptor (TCR) signalling from the moment T-cells become activated. CD5 is an essential mediator of cell survival and death and may help avoid autoimmunity and cancer.

Which cells express the CD5 protein?

Many T-cells and a fraction of B-cells express CD5. Human CD5 positive B lymphocytes can be seen in foetal lymphoid tissue, with their concentration decreasing with foetal age. CD5-positive B-cells have been discovered in the mantle zone and germinal centre of adult human tissues.

What does CD5 and CD10 negative imply?

Low-grade B-cell lymphoproliferative ailments (CD5-CD10-LPD) of the spleen are a remarkable category of neoplastic, indolent, and mature B-cell proliferation that are important to find but challenging to diagnose.

What is CD5-positive lymphoma, and how does it differ from other types of lymphoma?

Since the T-cell marker CD5 protein is frequently negative in follicular lymphoma, CD5 expression can help differentiate it from similar low-grade B-cell lymphomas. However, only a few cases of CD5+ follicular lymphoma have been documented.

What problems might the CD5 test help with?

CD5 antibody testing can be used to diagnose illnesses such as chronic lymphocytic leukaemia and mantle lymphoma, which are very rare. The lack of CD5 protein can be regarded as a sign of the disease's malignancy.

How can I interpret the results of my CD5 test?

If the health issues indicated by your doctor are discovered in the test, the outcome will be a positive result regardless of age or gender.

What dietary precautions do you need to take before undergoing CD5 antibody testing?

There are no food restrictions for the CD5 test; however, your doctor may advise you about dietary limitations for other tests.