Chronic Lymphoproliferative Disorder ( CLPD ) Panel - By Flow Cytometry

As the name suggests, the Chronic Lymphoproliferative Disorder Panel, is used to detect the presence of Chronic Lymphoproliferative Disorder. This inherited disorder inhibits your body from regulating leukocyte production.As a result, an excess of lymphocytes is produced, known as Lymphoproliferation.

This results in the excess accumulation of lymphocytes, further leading to the enlargement of your liver (Hepatomegaly), lymph nodes (Lymphadenopathy), and spleen (Splenomegaly).

If left unchecked, the disease may pave the way for various deadly complications. They are as follows:

• Lymphocytosis 
• Prolymphocytic Leukemia 
• Hairy Cell Leukemia 
• Large granular lymphocyte disorders 
• Natural killer cell Leukemia

Furthermore, the disease will also be characterized by autoimmune disorders. In this case, your immune system will attack your own tissues and organs. Most of these autoimmune diseases generally target blood cells.

For instance, your immune system may attack your RBCs (Autoimmune Hemolytic Anaemia), WBCs (Autoimmune Neutropenia), or platelets (Autoimmune Thrombocytopenia). In other rare instances, they might affect your nerves (Guillain-Barre syndrome), kidneys (glomerulonephritis), eyes (Uveitis), or liver (Autoimmune Hepatitis).

Moving on, the most commonly detected Lymphoproliferative disorder is Chronic Lymphocytic Leukemia. This disease progresses slowly and affects a certain group of Leukocytes. As a result, you will experience the following symptoms:

• Fever
• Fatigue
• Weight loss
• Night sweats 
• Enlarged lymph nodes (painless)
• Pain in the upper left abdomen 
• Frequent infections

If you feel you are experiencing any of the above symptoms, it is time to get the Chronic Lymphoproliferative Panel Test done now. Furthermore, you need to get the test done as soon as possible if you fall under any of the following risk factors:

• Your race
• Your age
• Exposure to chemicals 
• Family history of cancer 
• Already have a condition that produces excess lymphocytes

If this disease doesn't receive timely treatment, it can lead to quite a few deadly complications. They are as follows:

• Increased risk of other cancers
• Immune system issues
• Switch to a much more aggressive cancer
• Frequent infections
   

Frequently asked questions

Are there any risks or complications associated with the Chronic Lymphoproliferative Disorder Panel?

No, there are no such risks associated with the Chronic Lymphoproliferative Disorder Panel. The test uses a blood sample, which is drawn from your arm vein with the help of a needle. Hence, the most that could happen is some light scarring or bleeding at the point of contact with the needle.

How much is your life expectancy if you have CLD?

Once you have contracted Chronic Lymphoproliferative disorder, your life expectancy will be cut down quite a bit. On an average, the median survival post the detection of CLD is somewhere around 6 to 10 years.

What is the difference between Lymphoma and Lymphoproliferative Disorder?

There is not much difference between Lymphoma and a Lymphoproliferative disorder. However, you must note that CLD refers to the abnormal growth of Leucocytes (WBCs). This disorder is further categorized into chronic lymphocytic leukemia, monoclonal gammopathies, lymphoma, and acute lymphoblastic leukemia.

What type of Lymphoma is curable?

Hodgkin's disease, or Hodgkin Lymphoma, is the most curable form of Lymphoma. This disease begins in the bone marrow. However, it is possible to cure it entirely if you catch the disease a little early on. In fact, it is one of the most curable forms of cancer.

What are some of the most common complications that come with Chronic Lymphocytic Leukemia?

Here is a list of some of the most common CLL symptoms: Skin rashes Panniculitis Premature ovarian failure Arthritis Inflammation of blood vessels (vasculitis) Mouth sores Development of neurological damage

Will CLL affect your eyesight?

Yes, it is possible for CLL to affect your eyesight. Some of the most common eye-related symptoms of CLL are decrease or loss of vision, blurry vision, etc.

What are the various signs that your CLL is getting worse?

Here are some signs that you need to look out for in case your CLL is getting worse: Fever Unexplained weight loss Significant fatigue Swollen lymph nodes Night sweats