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HLA-DQ Typing

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  • HLA-DQ Typing

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About

blood sample
Sample

WHOLE BLOOD EDTA (DONOR) AND WHOLE BLOOD EDTA (RECIPIENT)

Gender
Gender

Both

users
Age group

7 years & above

HLA-DQ typing test is used to diagnose celiac disease which is an autoimmune disorder in which the gluten consumption leads to inflammation in the small intestine. Left untreated, it can lead to serious health problems. Celiac disease is strongly associated with the HLA genetic region.

HLA-DQ Typing Test - Overview

HLA-DQ typing test confirms the presence or absence of autoimmune disorders. It is a genotyping test for symptomatic individuals.

The presence of HLA-DQ2 and HLA-DQ8 could be a prediction tool for confirming celiac disease in a person. However, many people with related HLA-DQ molecules do not show disease symptoms.

Patients should undergo some additional tests to identify the symptoms of celiac disease. IgA deficiency test is recommended for this condition because people with celiac disease are likely to have IgA deficiency.

Initial screening can also include some tests related to celiac disease specifically. This can be a second step in confirming the condition based on symptoms and previous tests. Usually, patients must consume a gluten-based diet before the test. This will give accurate results about the disease.

In people with celiac disease, gluten consumption triggers an autoimmune reaction, leading to malabsorption of other nutrients.

The disease also involves damage to the lining of the small intestine. This can further worsen the condition. Hence, it is essential to seek an expert’s advice in this condition after going for the HLA-DQ typing test.

Some histologic tests study the change in the small intestine tissue. This gives a deeper insight into the extent of damage caused by the disease.

Who Should Get Tested?

Celiac disease affects children and adults. In children, its symptoms include poor development, delay in puberty, gastrointestinal symptoms, and anaemia. Chronic symptoms in adults consist of unexplained anaemia, dermatitis, and early osteoporosis. Celiac disease is more common in people with chromosomal disorders such as Turner syndrome and Down syndrome. Immune illnesses like type-1 diabetes, thyroiditis, and liver disease can also increase the risk of celiac disease.

Genetic screening can play an essential role in the testing since many patients have a family history of celiac disease. 

faqFrequently Asked Questions (FAQs)

HLA-DQ typing test detects and assesses the celiac disease-related alleles that show an inclination towards the disorder but are not diagnostic of the celiac disease. Around 95% of celiac patients show positive results for DQ2 or DQ8, but many people displaying these genetic results may not develop celiac disease.
Celiac disease, also often known as gluten-sensitive enteropathy or celiac sprue, is your immune system’s reaction upon eating gluten. Gluten is a protein that is found in barley, wheat, and rye. If you have gluten intolerance, consuming it will trigger a severe immune response in the small intestine. This is known as celiac disease.
Celiac disease may vary significantly from person to person. Its symptoms look different in young children and adults. For adults, these signs and symptoms may include: Fatigue Diarrhoea Unintentional and sudden loss of weight Abdominal pain Gas and bloating Constipation Nausea Vomiting Anaemia, caused by iron deficiency Blistery, itchy red rash known as dermatitis herpetiformis Osteoporosis, wherein bones lose their density Osteomalacia, wherein bones soften up Headaches Mouth ulcers Joint pain Nervous system injury, which includes tingling and numbing in limbs, balance troubles, and cognitive impairment Hyposplenism, wherein the spleen’s function reduces
Young kids display different symptoms of celiac disease and are more likely to deal with digestive system issues. These symptoms may look like this: Chronic diarrhoea Nausea Vomiting Constipation Swollen belly Gas Foul-smelling, pale-looking stools These symptoms and issues may lead to the inability to absorb nutrients which may stunt the children’s growth, damage their enamel, cause anaemia, weight loss, irritability, and delayed puberty. It may also lead to neurological issues like ADHD, lack of muscle coordination, and learning disabilities.
No, there is no known cure for celiac disease. You can only manage its symptoms by preventing the consumption of gluten altogether. Once gluten is eliminated, the small intestine will begin to heal.

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HLA-DQ Typing near you

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The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results