apollo

He4: Human Epididymis Protein 4 in Rethibowli, Hyderabad

No preparation required

MRP466725% off
3500
circle logo₹175 cashback

testsTest(s) Included (1)

  • He4: Human Epididymis Protein 4

    1 test included

    expand

About

blood sample
Sample

BLOOD

Gender
Gender

Both

users
Age group

7 years & above

The majority of epithelial ovarian cancer cells generate a protein called Human Epididymis Protein 4 (HE4). The HE4 level in the blood is determined using the HE4 test. In particular situations, this renders the HE4 test useful as a tumour marker.

A woman with epithelial ovarian cancer has a significantly high concentration of HE4 in her blood. When HE4 levels rise, the HE4 test can be performed to check for cancer development or recurrence and gauge how well the treatment is working.

Ovarian cancer is the fifth most common cause of cancer-related death among women. The most prevalent kind of ovarian cancer is epithelial. It contributes to 80% to 90% of ovarian cancer cases and develops in cells lining the ovaries' exterior.

Endometrioid, Clear Cell, Serous, and Mucinous, are a few of the subcategories of epithelial ovarian cancer, with Serous being the most prevalent. According to several research studies, HE4 is typically elevated in Mucinous malignancies but not in the majority of Endometrioid and Serous epithelial ovarian cancers and around half of Clear Cell tumours. So, individuals with other forms of ovarian cancer, such as Germ Cell or Mucinous tumours, are not monitored with HE4.

Women receiving treatment for epithelial ovarian cancer are followed up with Cancer Antigen 125 (CA-125) and Human Epididymis Protein 4. Before therapy, HE4 must be elevated to be effective as a tumour marker. The primary technique employed to monitor ovarian malignancies is CA-125; however, not all tumours have elevated levels. Hence, scientists are still looking for tumour indicators that are more accurate and precise.

The HE4 test at Apollo 24|7 provides valuable insights into epithelial ovarian cancer. The test's findings could indicate any of the following:

Epithelial ovarian cancer typically responds to treatment if HE4 and CA-125 levels were originally elevated and subsequently decreased after the treatment.

If levels increase or remain unchanged, the malignancy has probably not responded. Following cancer treatment or surgery, rising levels of HE4 and CA-125 may be discovered during routine monitoring. This can mean that cancer has resurfaced. 

An elevated ROMA score can indicate that the pelvic mass is more probable to be cancerous in a woman who suffers from a lump in her pelvis and will be having surgery.

The test is ineffective in tracking a woman's ovarian cancer if her baseline HE4 is normal after a diagnosis of epithelial ovarian cancer.

If you have non-epithelial ovarian cancer, this test would not be recommended. If your malignancy does not result in increased HE4 production, the HE4 test would not be practical as a monitoring tool. 
 

Medically reviewed by Dr. Sanjaya Mishra, Radiation Oncology, Apollo Hospitals Old Sainik School Road, Bhubaneswar.

faqFrequently Asked Questions (FAQs)

What does the HE4 test entail?

Most epithelial ovarian cancer cells, but not all, generate the protein known as Human Epididymis Protein 4 (HE4). The test is hence advantageous as a tumour marker in some situations. The Human Epididymis Protein 4 level in the blood is determined using the HE4 test.

How does a woman's high HE4 level affect her?

A woman with epithelial ovarian cancer typically has blood with noticeably higher levels of Human Epididymis Protein 4. When HE4 levels rise, the HE4 test may be used to check for cancer development or recurrence as well as to gauge how well the treatment is working.

Is HE4 the same as CA125?

HE4 is more precise and effective in spotting early-stage ovarian cancer. In ovarian cancer, HE4 boosts the usefulness of Cancer Antigen 125 (CA125) as a tumour marker, and the sensitivity of the tumour marker is increased when both markers are used together.

What causes HE4 to test falsely positive?

Renal dysfunction is the most frequent factor in false-positive values for HE4. Patients with innocuous gynaecological problems exhibit lower HE4 levels than individuals with renal impairment. Pseudo-positive HE4 readings are also observed in patients with liver or lung illness, effusions, or both.

What is the average HE4 range?

The HE4 reference threshold for healthy people is 85 pmol/l; for the pre and postmenopausal categories, it is 73 pmol/l and 94 pmol/l, respectively.

What local labs offer the HE4 test, and where can I find them?

Apollo 24

Most Popular tests & packages

Complete Blood Count (CBC) in Rethibowli, Hyderabad | Glucose, Fasting in Rethibowli, Hyderabad | HbA1c, Glycated Hemoglobin in Rethibowli, Hyderabad | Dengue NS1 Antigen - Elisa in Rethibowli, Hyderabad | Complete Urine Examination in Rethibowli, Hyderabad | Glucose, Post Prandial (PP), 2 Hours (Post Meal) in Rethibowli, Hyderabad | Lipid Profile in Rethibowli, Hyderabad | Liver Function Test (LFT) in Rethibowli, Hyderabad | Thyroid Profile (Total T3, Total T4, TSH) in Rethibowli, Hyderabad | Thyroid Stimulating Hormone (TSH), Serum in Rethibowli, Hyderabad | C - Reactive Protein CRP (Quantitative) in Rethibowli, Hyderabad | Creatinine, Serum in Rethibowli, Hyderabad | Platelet Count in Rethibowli, Hyderabad | Culture And Sensitivity Urine in Rethibowli, Hyderabad | Peripheral Smear For Malarial Parasite (MP) in Rethibowli, Hyderabad | Renal Profile/Renal Function Test (RFT/KFT) in Rethibowli, Hyderabad | Widal Test ( Slide Method ) in Rethibowli, Hyderabad | Glucose, Random in Rethibowli, Hyderabad | Dengue Profile - Elisa in Rethibowli, Hyderabad | Uric Acid - Serum in Rethibowli, Hyderabad | Erythrocyte Sedimentation Rate (ESR) in Rethibowli, Hyderabad | Total Beta - HCG (TB-HCG) in Rethibowli, Hyderabad | Hemoglobin in Rethibowli, Hyderabad | Hemogram in Rethibowli, Hyderabad | Electrolytes - Serum in Rethibowli, Hyderabad | Vitamin B12 in Rethibowli, Hyderabad | Prothrombin Time (PT/INR) in Rethibowli, Hyderabad | Potassium - Serum / Plasma in Rethibowli, Hyderabad | Thyroid Profile - Free (FT3, FT4, TSH) in Rethibowli, Hyderabad | Urea And Creatinine in Rethibowli, Hyderabad | Sodium - Serum in Rethibowli, Hyderabad | Vitamin D - 25 Hydroxy (D2+D3) in Rethibowli, Hyderabad | Blood Group ABO And RH Factor in Rethibowli, Hyderabad | Dengue Fever NS1 Antigen, Rapid in Rethibowli, Hyderabad | Hiv Rapid in Rethibowli, Hyderabad

He4: Human Epididymis Protein 4 near you

He4: Human Epididymis Protein 4 in Beeramguda | He4: Human Epididymis Protein 4 in Begumpet | He4: Human Epididymis Protein 4 in Kondapur Junction | He4: Human Epididymis Protein 4 in Kondapur | He4: Human Epididymis Protein 4 in Kukatpally Housing Board Colony | He4: Human Epididymis Protein 4 in Kukatpally Metro Parking | He4: Human Epididymis Protein 4 in Lingampally | He4: Human Epididymis Protein 4 in Madhapur | He4: Human Epididymis Protein 4 in Manikonda | He4: Human Epididymis Protein 4 in Miyapur | He4: Human Epididymis Protein 4 in My Home Jewel Road | He4: Human Epididymis Protein 4 in Nizampet | He4: Human Epididymis Protein 4 in Sri Lakshmi Residency | He4: Human Epididymis Protein 4 in Malkajgiri | He4: Human Epididymis Protein 4 in Gachibowli | He4: Human Epididymis Protein 4 in Gopanapalli | He4: Human Epididymis Protein 4 in Jagadgiri Gutta | He4: Human Epididymis Protein 4 in Kanaka Durga Temple | He4: Human Epididymis Protein 4 in Masjid Banda | He4: Human Epididymis Protein 4 in Mayuri Nagar Welfare Association | He4: Human Epididymis Protein 4 in Palm Breeze Rd | He4: Human Epididymis Protein 4 in Pragathi Enclave | He4: Human Epididymis Protein 4 in Rtc Colony | He4: Human Epididymis Protein 4 in Kothaguda X Road | He4: Human Epididymis Protein 4 in Rethibowli | He4: Human Epididymis Protein 4 in Banjara Hills | He4: Human Epididymis Protein 4 in Borabanda | He4: Human Epididymis Protein 4 in Kukatpally | He4: Human Epididymis Protein 4 in Hitech City | He4: Human Epididymis Protein 4 in Bhaskar Nagar | He4: Human Epididymis Protein 4 in Manikonda | He4: Human Epididymis Protein 4 in Balanagar Township | He4: Human Epididymis Protein 4 in Hmt Township | He4: Human Epididymis Protein 4 in Nizampet | He4: Human Epididymis Protein 4 in Administrative Buildings | He4: Human Epididymis Protein 4 in Amberpet | He4: Human Epididymis Protein 4 in Attapur | He4: Human Epididymis Protein 4 in Central Secretariat | He4: Human Epididymis Protein 4 in Dattatreya Colony | He4: Human Epididymis Protein 4 in Falaknuma | He4: Human Epididymis Protein 4 in Hasannagar | He4: Human Epididymis Protein 4 in I.e.nacharam | He4: Human Epididymis Protein 4 in Jubilee Hills | He4: Human Epididymis Protein 4 in Malakpet Colony | He4: Human Epididymis Protein 4 in Raj Bhawan | He4: Human Epididymis Protein 4 in Sitaphalmandi | He4: Human Epididymis Protein 4 in Cuc | He4: Human Epididymis Protein 4 in Manuu | He4: Human Epididymis Protein 4 in Bowenpally

Popular tests in Rethibowli, Hyderabad

Urea And Creatinine in Rethibowli, Hyderabad | Sodium - Serum in Rethibowli, Hyderabad | Electrolytes - Serum in Rethibowli, Hyderabad | Blood Group ABO And RH Factor in Rethibowli, Hyderabad | Thyroid Profile - Free (FT3, FT4, TSH) in Rethibowli, Hyderabad | Hiv Rapid in Rethibowli, Hyderabad | Hemogram in Rethibowli, Hyderabad | Ferritin in Rethibowli, Hyderabad | 25-Hydroxy Vitamin D (D2+D3) in Rethibowli, Hyderabad | SGPT/ALT (Alanine Aminotransferase) in Rethibowli, Hyderabad | Widal Test ( Slide Method ) in Rethibowli, Hyderabad | Calcium - Serum in Rethibowli, Hyderabad | HBsAg Screening - Rapid in Rethibowli, Hyderabad | Testosterone (TOTAL) in Rethibowli, Hyderabad | Cholesterol - Serum in Rethibowli, Hyderabad | Peripheral Smear For Malarial Parasite (MP) in Rethibowli, Hyderabad | Apollo Basic Hormone Check in Rethibowli, Hyderabad | Dengue NS1 Antigen - Elisa in Rethibowli, Hyderabad | Prolactin in Rethibowli, Hyderabad | VDRL (RPR) in Rethibowli, Hyderabad

Popular packages in Rethibowli, Hyderabad

Apollo Womens Health - Essential in Rethibowli, Hyderabad | Apollo Vitamin Check - Advance in Rethibowli, Hyderabad | Apollo Womens Health - Basic in Rethibowli, Hyderabad | Apollo Thyroid Assessment - Essential in Rethibowli, Hyderabad | Apollo PCOD Basic in Rethibowli, Hyderabad | Apollo Kidney Check - Basic in Rethibowli, Hyderabad | Apollo Fever Panel - Essential in Rethibowli, Hyderabad | Essential Panel (Heart, Liver, Kidney and Sugar) in Rethibowli, Hyderabad | Apollo Vitamin Check - Essential in Rethibowli, Hyderabad | Apollo Vitamin Check in Rethibowli, Hyderabad | Apollo Full Body Check - Advance I in Rethibowli, Hyderabad | Apollo Hairfall Check Advance Male in Rethibowli, Hyderabad | Apollo Kidney Check - Advance in Rethibowli, Hyderabad | Apollo Hairfall Check Advance Female in Rethibowli, Hyderabad | Apollo Senior Citizens Care Female - Advance in Rethibowli, Hyderabad | Apollo Diabetes Panel - Advance Male in Rethibowli, Hyderabad | Apollo PCOD Comprehensive in Rethibowli, Hyderabad | Apollo Womens Health - Advance in Rethibowli, Hyderabad | Free And Total Thyroid Profile (T3,T4, FT3, FT4,TSH) in Rethibowli, Hyderabad | Holistic Health Check for Women in Rethibowli, Hyderabad

Why should Apollo be your preferred healthcare partner?

  • 40 Years of legacy and credibility in the healthcare industry.
  • NABL certified multi-channel digital healthcare platform.
  • Affordable diagnostic solutions with timely and accurate test results.
  • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
  • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results