IMMUNOGLOBULIN IGG SUBCLASS 4 in Shivaji-nagar, Chennai

Immunoglobulin IgG Subclass 4: Price, Purpose, Range & Reports

Test Overview

The Immunoglobulin IgG Subclass 4 Test is a specialised blood test used to measure the concentration of the least abundant of the four Immunoglobulin G (IgG) subclasses. IgG antibodies are crucial components of the immune system, providing long-term protection against bacteria and viruses. While total IgG measurement is common, measuring the specific subclasses (IgG1, IgG2, IgG3, and IgG4) is necessary to diagnose subtle defects in the body’s specific antibody production.
This test is often known as the IgG4 Level Test or Serum Immunoglobulin G Subclass 4. It is a key tool for diagnosing certain primary immunodeficiency disorders (where low levels are found) or a specific fibro-inflammatory condition known as IgG4-Related Disease (IgG4-RD, where high levels are found). If you are searching for a reliable Immunoglobulin IgG Subclass 4 Test price or a convenient test near me, Apollo 24|7 provides accredited laboratory services with timely collection and secure, fast report access.

What is the Immunoglobulin IgG Subclass 4 Test?

Immunoglobulins, or antibodies, are proteins produced by plasma cells (a type of white blood cell) to defend the body against pathogens. Immunoglobulin G (IgG) makes up about 70-75% of all immunoglobulins and is divided into four subclasses: IgG1, IgG2, IgG3, and IgG4.

The IgG Subclass 4 Test specifically measures the level of IgG4 in the blood. Although IgG4 is typically the least common, usually representing less than 5% of the total IgG, it plays a role in tolerance to foreign antigens and is known for its involvement in certain allergic responses and specific diseases.

• Low Levels: Abnormally low levels of IgG4, often along with low levels of other subclasses, can point towards a primary or secondary immunodeficiency, making the patient susceptible to recurrent, severe infections (especially respiratory).
• High Levels: Markedly elevated IgG4 levels are the primary biochemical marker for IgG4-Related Disease (IgG4-RD), a condition characterised by widespread inflammation, fibrosis (scarring), and tumour-like swelling of various organs (e.g., pancreas, bile ducts, kidneys, salivary glands).

Doctors use this test when standard tests for total immunoglobulins are normal but specific immune problems or unexplained multi-organ inflammation are suspected.

What is the Immunoglobulin IgG Subclass 4 Test Price?

The Immunoglobulin IgG Subclass 4 Test price reflects the complex, specialised technology required for the quantitative measurement of a specific, low-concentration protein in the blood. The final cost of your test is influenced by several elements:

• Technology Used: The test relies on advanced nephelometry or turbidimetry techniques, which are highly sensitive and necessary for accurately quantifying the low concentration of the IgG4 subclass.
• Location: Prices may differ slightly between cities due to regional operating costs and logistics.
  Service Type: Opting for home sample collection may slightly adjust the total cost due to convenience and travel charges.
• Lab Accreditation: Tests conducted at NABL-accredited labs, such as those operated by Apollo, ensure high standards of accuracy and reliability, which is essential for diagnosing complex immune conditions.

If you're trying to find the most accurate and affordable Immunoglobulin IgG Subclass 4 Test price near me, the easiest way is to check the Apollo 24|7 website or app. They update prices regularly based on your location, so you’ll always see the latest rates and any available offers.

What is the Purpose of the Immunoglobulin IgG Subclass 4 Test?

The primary purpose of the Immunoglobulin IgG Subclass 4 Test is to assess the specific antibody components of the immune system for diagnosis and monitoring.

Doctors recommend the IgG Subclass 4 Test for the following key objectives:

• Diagnose Primary Immunodeficiency: To identify specific deficiencies, particularly common variable immunodeficiency (CVID) or selective IgG subclass deficiencies, where low IgG4 levels contribute to recurrent bacterial infections.
• Diagnose IgG4-Related Disease (IgG4-RD): To confirm the diagnosis of this systemic inflammatory condition, which is almost always associated with significantly elevated serum IgG4 concentrations.
• Investigate Recurrent Infections: To find the underlying cause of frequent or unusually severe respiratory tract infections, particularly in children and adults with normal total IgG levels.
• Monitor Disease Activity and Treatment: To track the effectiveness of treatment (like steroids) for patients diagnosed with IgG4-RD; levels are expected to decrease when treatment is successful.

Who Should Get an Immunoglobulin IgG Subclass 4 Test Done?

The IgG Subclass 4 Test is typically ordered by allergists, immunologists, or rheumatologists when specific clinical pictures suggest an underlying immune or inflammatory disorder.

Doctors may recommend this test if you fall into one of these groups:

• Patients with Unexplained Recurrent Infections: Especially those suffering from chronic sinus infections, frequent pneumonia, or bronchitis, despite having normal total immunoglobulin levels.
• Patients Suspected of IgG4-Related Disease (IgG4-RD): Individuals presenting with multi-organ swelling and inflammation, such as autoimmune pancreatitis, sclerosing cholangitis, chronic sialadenitis, or retroperitoneal fibrosis.
• Evaluation of Chronic Allergic Conditions: Though less common, it may be used in the investigation of certain allergic or autoimmune conditions where IgG4 levels are suspected to play a role.
• Family History of Immunodeficiency: Individuals with a close relative diagnosed with a primary antibody deficiency.

Components of the Immunoglobulin IgG Subclass 4 Test

This diagnostic test is focused on quantifying a single, specific protein component of the immune system.

The test is performed for:

• Immunoglobulin IgG Subclass 4 (IgG4): This parameter measures the concentration of the IgG4 antibody subclass, crucial for identifying specific immune defects or the presence of IgG4-Related Disease.

Understanding an Immunoglobulin IgG Subclass 4 Test Report

The Immunoglobulin IgG Subclass 4 Test is a quantitative blood test. Results are typically reported in milligrams per decilitre (mg/dL) or grams per litre (g/L), and the normal range is highly dependent on the patient's age and the specific laboratory's method.

Note: Unlike total IgG, IgG4 levels vary widely, and age-specific reference intervals are critical for accurate interpretation.

• A Low result (Below the Age-Specific Reference Range) usually indicates an IgG4 deficiency. This may lead to an inability to effectively fight off certain bacterial infections, particularly in the respiratory tract. Further testing (like antibody response to vaccines) is usually required to confirm an immunodeficiency diagnosis.
• A High result (Above the Age-Specific Reference Range) is strongly associated with an active IgG4-Related Disease (IgG4-RD). The higher the elevation, the more likely the diagnosis. However, elevated levels can also be seen in some allergic conditions, specific parasitic infections, or other inflammatory disorders. Therefore, the result must be interpreted alongside imaging, organ biopsies, and clinical symptoms.

The IgG4 level should always be reviewed by a specialist (Immunologist or Rheumatologist) who will guide you on the next steps based on your complete clinical picture, as no single laboratory test is definitive for these complex conditions.

Preparation and Procedure for Immunoglobulin IgG Subclass 4 Test

This test is straightforward and involves a standard blood draw.

1. How is the Test Done?

The Immunoglobulin IgG Subclass 4 Test requires the collection of a venous blood sample. The procedure is quick and performed by a certified phlebotomist, who will draw blood from a vein in your arm. The sample is then sent to the laboratory for quantitative analysis.

2. Is Fasting Required for This Test?

No, fasting is not required for the Immunoglobulin IgG Subclass 4 Test. Eating or drinking does not interfere with the concentration measurement of this antibody subclass.

3. What Time of the Day Should I Undergo the Test?

You can undergo this test at any time of the day.

4. How Frequently Should I Undergo the Test?

The test is initially ordered for diagnostic purposes. If you are diagnosed with IgG4-RD, the test may be repeated periodically (e.g., every 3-6 months) to monitor the effectiveness of treatment and track disease activity, as advised by your physician.

Booking Immunoglobulin IgG Subclass 4 Test Online & Checking Reports

Apollo 24|7 simplifies the process of obtaining this critical diagnostic test, allowing you to schedule your collection and access your results securely online, ensuring timely communication with your doctor.

A. What are the Steps to Schedule the Test on Apollo 24|7?

1. Visit the Apollo 24|7 website or mobile application and search for the Immunoglobulin IgG Subclass 4 Test.
2. Confirm the latest Immunoglobulin IgG Subclass 4 Test price for your city and click the 'Book Now' button.
3. Select your preferred date and a convenient time slot for home collection.
4. Complete the secure online payment. Confirmation details and preparation reminders will be sent instantly.

B. How Do I Access My Test Results Online on Apollo 24|7?

1. Log in to your Apollo 24|7 account using your registered phone number or email.
2. Navigate to the 'Health Records' or 'My Reports' section on the dashboard.
3. Click on your completed test name to view the detailed report immediately.
4. You can easily view the entire report online or download it in PDF format to share with your physician.

Conclusion

The Immunoglobulin IgG Subclass 4 Test is an invaluable tool for immunologists and rheumatologists, providing critical insight into the subtle functioning of the adaptive immune system. It serves to diagnose specific immunodeficiency syndromes that cause recurrent infections and is the primary blood marker for the complex multi-organ inflammatory disorder, IgG4-Related Disease.
Because the interpretation of IgG4 levels requires specific clinical correlation, the test is always interpreted alongside a thorough review of your symptoms and history. For accurate and timely testing, platforms like Apollo 24|7 offer access to certified labs and dependable reporting, helping your doctor make informed decisions about your care.