INFLAMMATORY BOWEL DISEASE SEROLOGY PROFILE (ANCA-IFA AND ASCA IGA,IGG) in Bangalore

Inflammatory Bowel Disease Serology Profile (ANCA-IFA AND ASCA IgA, IgG): Price, Purpose, Range & Reports

The Inflammatory Bowel Disease (IBD) Serology Profile is a specialised blood test panel designed to aid in the diagnosis and differentiation of the two major forms of IBD: Crohn's Disease (CD) and Ulcerative Colitis (UC). IBD encompasses chronic inflammatory disorders of the gastrointestinal (GI) tract. While both conditions share many symptoms (diarrhoea, abdominal pain, weight loss), distinguishing between them is crucial for effective treatment planning.
This profile measures the presence and levels of specific antibodies, including Anti-Neutrophil Cytoplasmic Antibodies (ANCA) and Anti-Saccharomyces Cerevisiae Antibodies (ASCA). The pattern of these antibodies often correlates strongly with the type of IBD present: ASCA positivity is more typical of CD, while ANCA positivity (specifically pANCA) is more typical of UC. This serological testing is a non-invasive tool used alongside clinical evaluation, endoscopy, and imaging studies to establish a precise diagnosis. If you are looking for a reliable IBD Serology Profile Test price or a convenient lab test near me, Apollo 24|7 provides accredited laboratory services with timely collection and secure, fast report access.

What is the Inflammatory Bowel Disease Serology Profile?

The Inflammatory Bowel Disease (IBD) Serology Profile is a specialised blood test that measures specific antibodies produced by the immune system in response to certain triggers in the digestive tract. This test is particularly useful when symptoms overlap or when other diagnostic tools, such as imaging or endoscopy, do not provide a clear diagnosis.
The profile typically includes testing for Anti-Saccharomyces cerevisiae antibodies (ASCA), both IgA and IgG, which are more commonly associated with Crohn’s disease, and Anti-Neutrophil Cytoplasmic Antibodies (ANCA), detected via indirect immunofluorescence (IFA), which are more frequently seen in ulcerative colitis. While not definitive on their own, these markers offer valuable insight when interpreted alongside clinical symptoms, imaging, and biopsy findings, helping guide accurate diagnosis and personalised treatment planning.

What is the Inflammatory Bowel Disease Serology Profile Price?

The IBD Serology Profile Test price is higher than routine blood tests due to the complexity of the assays required to detect four distinct markers (ANCA by IFA, ASCA IgA, and ASCA IgG). The final cost of your test is influenced by several elements:
•    Complexity of Assays: This panel involves multiple specialised tests, including Indirect Immunofluorescence Assay (IFA) for ANCA and Enzyme-Linked Immunosorbent Assays (ELISA) for ASCA IgA and IgG.
•    Location: Prices may differ slightly between cities due to regional operating costs and logistics.
•    Service Type: Opting for home sample collection may slightly adjust the total cost due to convenience and travel charges.
•    Lab Accreditation: Tests conducted at NABL-accredited labs, such as those operated by Apollo, ensure high standards of accuracy and reliability, which is essential for results used in clinical assessments.
If you're trying to find the most accurate and affordable IBD Serology Profile Test price near me, the easiest way is to check the Apollo 24|7 website or app. They update prices regularly based on your location, so you’ll always see the latest rates and any available offers.

What is the Purpose of the IBD Serology Profile Test?

The primary purpose of the IBD Serology Profile is to aid clinicians in establishing a diagnosis of IBD and, more importantly, to differentiate between Crohn's Disease and Ulcerative Colitis.
Doctors recommend the IBD Serology Profile for the following key objectives:
•    Differentiation of CD from UC: The unique antibody patterns (ASCA+/ANCA- for CD; ASCA-/ANCA+ for UC) help distinguish between the two diseases, which is critical for selecting appropriate therapies.
•    Diagnosis in Ambiguous Cases: When endoscopy or imaging results are inconclusive, or when the disease presents atypically, these serological markers provide additional diagnostic evidence.
•    Prognosis and Disease Classification: The presence of specific antibodies (especially high levels of ASCA) may correlate with a more severe or complicated disease course in some patients with Crohn's Disease.
•    Evaluation of Indeterminate Colitis: To help classify patients whose initial diagnosis is "indeterminate colitis" (a condition where features of both CD and UC exist).

Who Should Get an IBD Serology Profile Test Done?

This test is indicated for patients presenting with chronic or recurrent gastrointestinal symptoms that suggest Inflammatory Bowel Disease.

You may be advised to take this test if:

•    You have Chronic GI Symptoms: Such as persistent or bloody diarrhoea, recurring abdominal pain, unexplained weight loss, fever, or fatigue.
•    Your Doctor Suspects IBD: Following a physical examination and initial blood work (e.g., high C-Reactive Protein or low haemoglobin) that points toward chronic inflammation.
•    You are Being Evaluated for IBD: This test is typically ordered as part of the initial comprehensive IBD workup, alongside colonoscopy, biopsy, and cross-sectional imaging (CT or MRI enterography).
•    You have been diagnosed with Indeterminate Colitis: To help reclassify your condition as either CD or UC for better treatment stratification.
•    You are a child or adolescent presenting with GI symptoms, as IBD presentation can be less classic in paediatric populations.
Always consult your doctor if you notice unusual or chronic GI symptoms. They will determine if this specialised profile is necessary based on your clinical presentation.

Components of the Inflammatory Bowel Disease Serology Profile

The IBD Serology Profile includes a set of blood tests that measure specific antibodies associated with immune responses in the gastrointestinal tract. These markers help differentiate between Crohn’s disease and ulcerative colitis, especially when clinical findings are inconclusive.

Key Markers Included:

•    ANCA - IFA (Anti-Neutrophil Cytoplasmic Antibody) 
This test uses Indirect Immunofluorescence Assay (IFA) to detect antibodies targeting proteins within white blood cells (neutrophils). A perinuclear staining pattern (pANCA) is commonly associated with ulcerative colitis (UC).
•    ASCA IgA (Anti-Saccharomyces cerevisiae Antibody) 
Performed using ELISA, this test identifies IgA antibodies against mannans found in the cell wall of the yeast Saccharomyces cerevisiae. A positive result is strongly linked to Crohn’s disease (CD).
•    ASCA IgG (Anti-Saccharomyces cerevisiae Antibody) 
Also measured via ELISA, this test detects IgG antibodies against the same yeast components. Positivity for either IgA, IgG, or both increases the likelihood of Crohn’s disease.

Understanding an IBD Serology Profile Test Report

The report will indicate whether each marker is detected (positive/reactive) or not detected (negative/non-reactive), often providing a quantitative titre or index value. The key lies in the pattern of positive and negative results across the markers.
 

Important Note: The Inflammatory Bowel Disease (IBD) Serology Profile is a supportive diagnostic tool used to help differentiate between Crohn’s disease and ulcerative colitis. While it provides valuable insights based on antibody patterns, it is not a standalone test and cannot confirm or rule out IBD on its own.
Results should always be interpreted by a qualified healthcare provider in combination with your symptoms, medical history, and other diagnostic procedures such as endoscopy, imaging, and biopsy. A positive or negative result does not guarantee the presence or absence of disease. This test is most useful when clinical findings are unclear and additional evidence is needed to guide diagnosis and treatment planning.

Preparation and Procedure for IBD Serology Profile Test

This test is straightforward and requires a standard blood draw.

1. How is the Test Done?

The test requires a blood sample (venipuncture), typically collected from a vein in your arm.
•    The Procedure: A phlebotomist will clean the area, insert a sterile needle to draw the required amount of blood into a collection tube, and then send the sample to the lab for the complex serological assays (IFA and ELISA).
•    Analysis: The assays detect the presence and quantify the levels of ANCA, ASCA IgA, and ASCA IgG antibodies.

2. Is Fasting Required for This Test?

No, fasting is not required for the IBD Serology Profile Test. You can eat and drink normally before the test.

3. What Time of the Day Should I Undergo the Test?

The test can be performed at any time of the day, as antibody levels are generally stable throughout the day.

4. How Frequently Should I Undergo the Test?

Repeat testing for this profile is usually not necessary once an IBD diagnosis is established, as the antibody patterns typically remain stable. It is primarily used as a diagnostic tool.

Booking IBD Serology Profile Test Online & Checking Reports

Apollo 24|7 simplifies the process of obtaining this diagnostic test, allowing you to schedule your collection and access your results securely online, ensuring timely communication with your doctor.

A. What are the Steps to Schedule the Test on Apollo 24|7?

1.    Visit the Apollo 24|7 website or mobile application and search for the IBD Serology Profile Test.
2.    Confirm the latest IBD Serology Profile Test price for your city and click the 'Book Now' button.
3.    Select your preferred date and a convenient time slot for home collection.
4.    Complete the secure online payment. Confirmation details and preparation reminders will be sent instantly.

B. How Do I Access My Test Results Online on Apollo 24|7?

1.    Log in to your Apollo 24|7 account using your registered phone number or email.
2.    Navigate to the 'Health Records' or 'My Reports' section on the dashboard.
3.    Click on your completed test name to view the detailed report immediately.
4.    You can easily view the entire report online or download it in PDF format to share with your physician.

Conclusion

The Inflammatory Bowel Disease Serology Profile is a highly valuable non-invasive tool in the complex evaluation of chronic gastrointestinal inflammation. By analysing the ANCA and ASCA antibody patterns, this profile significantly assists clinicians in differentiating between Crohn's Disease and Ulcerative Colitis, guiding essential treatment decisions. While serology is not the sole diagnostic criterion, the results, particularly in challenging cases, provide a strong immunological insight that complements endoscopy and imaging.