Anti Jo-I Antibody

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    blood sample




    Age group

    Above 10 years

    Antibodies are the disease-fighting proteins that allow your body to fight against infection or disorder. These vital proteins bind with the antigen or foreign substance in the body and destroy them, leaving memory cells behind. 
    The Anti-Jo-1 antibody is one such binding protein found in the blood of patients suffering from idiopathic inflammatory myopathies (IIM).

    The most commonly occurring IIM diseases include:

    • Dermatomyositis 
    • Polymyositis
    • Raynaud's phenomenon
    • Arthritis
    • Histidyl-tRNA Synthetase syndrome
    • Interstitial lung disease

    The IIM diseases like Histidyl-tRNA Synthetase syndrome attack muscular strength. This condition usually occurs in adults between 40-60 years and children aged 5-15. However, there is no specific age limit at which it starts deteriorating the body.

    Considering the rapid progression of Jo-1 IgG diseases, experts suggest the Anti-Jo-1 Antibody test as a part of a group of tests post a preliminary analysis. The primary symptoms that may prompt your doctor to recommend this test for IIM disorders diagnosis include: 

    • Recurrent low-grade fever
    • Persistent muscle pain
    • Anaemia
    • Joint pain and swelling
    • Rapid hair loss
    • Irregular heartbeat
    • Shortness of breath
    • Chronic tiredness
    • Lasting dry cough
    • Swallowing or breathing difficulty
    • Trouble holding items
    • Difficulty in walking

    As age progresses, the symptoms of anti-Jo-1 antibody diseases start affecting the whole body. The most prominent impacts are seen on the skin, skeletal muscles and lungs. If left undiagnosed or untreated, it can result in a physical disability, respiratory problem and even cardiovascular issues.

    Timely detection through the anti-Jo-1 blood test limits the spread of autoimmune diseases. The collection procedure for the anti-Jo-1 diagnosis is pretty simple. A lab technician will draw out a small amount of your blood using a sterilised needle and carefully store it in a vial. Some side effects that you might face after blood sample collection for the Jo-1 test can be:

    • Redness or bruising where the needle was inserted
    • Spot soreness or pain after the blood draw
    • Minor rashes
    • Lightheadedness
    • Nausea
    • A temporary drop in blood pressure or heart rate

    Most of these side effects are normal and last for about 1 to 2 days after the anti-Jo-1 antibody test. The aftereffects also depend on the needle treatment and body handling while drawing the sample.

    Apollo 24|7 offers the Jo-1 antibody test for a detailed understanding of your current health. The test results are given in Unit terms. To comprehend the report, you can consider the following range:

    • Less than 1.0 U is considered negative, implying no presence of Jo-1 IgG antibodies.
    • More than or equivalent to 1.0 U signals the presence of an anti-Jo-1 antibody in the bloodstream. 


      Medically edited by Dr. Sonia Bhatt.


    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    The Jo-1 IgG blood test detects the presence of histidyl-tRNA synthetase antibodies in the blood, which is related to idiopathic inflammatory myopathic diseases. These autoimmune diseases include polymyositis, dermatomyositis, arthritis, mechanic's hand, Raynaud phenomenon and pulmonary problems.
    The Jo-1 antibody blood test is prescribed by a medical professional upon considering your present body issues. Thus, if your problems include muscle pain, recurrent fever, breathing difficulty and movement problems, you can consult a doctor who will suggest a proper course of medication and treatment.
    Idiopathic inflammatory myopathies are a group of disorders that target the skeletal muscles of the body. Some common IIM diseases are polymyositis, dermatomyositis, interstitial lung ailments, arthritis, etc. These disorders weaken the body's muscles over the years, leading to difficulty in swallowing, breathing and mobility.
    The positive anti-Jo-1 antibody test result implies that the antibodies associated with IIM and autoimmune diseases are present in the body. This outcome helps the medical expert gauge your health situation for initiating the treatments of myositis, polymyositis syndromes and interstitial lung disease, i.e., autoimmune and IIM disorders.
    The doctor prescribes the anti-Jo-1 test after conducting a brief analysis of your current symptoms. The mild symptoms can indicate the onset of a disorder. So, it depends on the expert evaluation before undergoing the test.
    With the presence of autoantibodies for the Jo-1 antigen, the body exhibits a variety of symptoms. From joint swelling to breathing difficulty, the primary damage occurs in the skeletal muscles of the body. Prolonged existence of the disease and delayed treatment can result in cardiovascular issues, movement restrictions, physical disability and reduced life span.

    Why should Apollo be your preferred healthcare partner?

    • 40 Years of legacy and credibility in the healthcare industry.
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    • Affordable diagnostic solutions with timely and accurate test results.
    • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
    • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results