Quadruple Marker Test

Test Overview

What is the Quadruple Marker Test in Pregnancy?

The Quadruple Marker Test in pregnancy, also known as the Quad Screen or Quadruple Test, is a prenatal screening test that measures the levels of four substances in a pregnant woman's blood. This test helps assess the risk of certain birth defects and complications in the fetus, including:

• Alpha-fetoprotein (AFP): A protein produced by the fetus. High or low levels of AFP can indicate certain conditions, such as neural tube defects or Down syndrome.
• Human Chorionic Gonadotropin (hCG): A hormone produced by the placenta. Elevated or decreased levels of hCG can suggest conditions like Down syndrome or other chromosomal abnormalities.
• Estriol: A hormone produced by the placenta and the fetus. Abnormal levels can indicate a higher risk of certain birth defects.
• Inhibin-A: A hormone produced by the placenta. High levels may indicate an increased risk of Down syndrome or other chromosomal disorders.

The Quadruple Marker Test in pregnancy is usually performed between the 15th and 20th weeks of pregnancy. While it doesn't diagnose these conditions, it helps identify women who may be at higher risk, prompting further testing or monitoring.

It's important to note that the test results are used to calculate the probability of a problem and are not a definitive diagnosis. If the results suggest an increased risk, additional diagnostic tests such as amniocentesis or chorionic villus sampling (CVS) may be recommended for confirmation.

What is the Quadruple Marker Test Price?

Quadruple Marker Test  Price in Different Cities

The Quadruple Marker Test price in India can vary based on the laboratory, location, and additional services offered.

• Test Type: The cost of the Quadruple Marker Test typically ranges from ₹3,200 to ₹5,600 in India. This second-trimester prenatal screening measures levels of specific substances in the mother's blood to assess the risk of genetic disorders and birth defects in the baby. It is a standard test offered by diagnostic centres and hospitals.
• Location: The geographical area where the test is conducted can greatly influence the cost. In metropolitan cities like Mumbai, Delhi, or Bangalore, the cost may be slightly higher due to advanced facilities and greater demand. In smaller towns, the test might be comparatively more affordable but could have limited availability.
• Lab Quality: The reputation and technology of the laboratory play a role in the cost. Premium diagnostic centres equipped with cutting-edge technology and expert professionals may charge higher rates, but they provide more reliable and accurate results.
• Additional Services: Services like home sample collection, quicker result delivery, or online consultations with doctors might add to the overall cost. These conveniences, while helpful, may come with an additional fee depending on the provider.
• Discounts and Promotions: Many diagnostic centres, such as Apollo 24|7, often provide discounts or bundled packages for prenatal tests, reducing the total quadruple marker test cost. Be sure to check the latest deals on their official websites or apps to make the most of these savings.

What is the Purpose of the Quadruple Marker Test?

The purpose of the Quadruple Marker Test is to screen for potential genetic disorders and birth defects in a developing baby during the second trimester of pregnancy. This blood test measures four markers — Alpha-fetoprotein (AFP), Human Chorionic Gonadotropin (hCG), Unconjugated Estriol (uE3), and Inhibin-A — to assess the risk of conditions such as:

• Down Syndrome (Trisomy 21)
• Edward’s Syndrome (Trisomy 18)
• Neural Tube Defects (e.g., spina bifida)

While it does not provide a definitive diagnosis, the Quadruple Marker Test helps healthcare providers identify pregnancies at higher risk, allowing for further diagnostic testing and informed decision-making about the pregnancy.

Who Should Get a Quadruple Marker Test Done?

A Quadruple Marker Test is recommended for the following individuals:

Pregnant Women in the Second Trimester

Typically performed between the 15th and 20th weeks of pregnancy, this test is often part of routine prenatal care to screen for birth defects and genetic conditions.

Women Aged 35 or Older

Advanced maternal age increases the risk of chromosomal abnormalities, such as Down syndrome, making this test particularly beneficial for older mothers.
Those with a Family History of Genetic Disorders

Women with a family history of genetic conditions, such as birth defects or inherited disorders, may benefit from the test to assess the risk of similar issues in the pregnancy.

Women with Abnormal First-Trimester Screening Results

The Quadruple Marker Test may be used to follow up on any abnormal findings from earlier screenings, offering further insight into potential risks.

Pregnancies with Certain Risk Factors

Women with certain health conditions, such as diabetes, obesity, exposure to medications, or a history of previous pregnancies with genetic abnormalities, may be advised to undergo this test for added risk assessment.

Components of the Quadruple Marker Test

Here are the key components measured in the Quadruple Marker Test:

• Alpha-fetoprotein (AFP)
• A protein produced by the baby’s liver and yolk sac.
• Helps assess the risk of neural tube defects, such as spina bifida, and other abnormalities in fetal development.
• Human Chorionic Gonadotropin (hCG)
• A hormone produced by the placenta during pregnancy.
• Abnormal levels can indicate chromosomal conditions like Down syndrome (Trisomy 21).
• Unconjugated Estriol (uE3)
• A form of estrogen produced by the fetus and the placenta.
• Low levels might suggest conditions such as Edward’s syndrome (Trisomy 18) or other developmental problems.
• Inhibin-A
• A hormone secreted by the placenta.
• Elevated levels are associated with an increased risk of Down syndrome.

Understanding the Quadruple Marker Test Report

Here’s a breakdown of the components, normal range, and what deviations from the normal range indicate:

Note: The interpretation of Quadruple Marker Test results must consider maternal factors such as age, weight, and medical conditions, as these can affect marker levels. Abnormal results should be assessed alongside clinical findings, and further diagnostic tests, like amniocentesis, may be required for confirmation.

Preparation and Procedure for the Quadruple Marker Test

Before undergoing a Quadruple Marker Test, it's important to understand the necessary preparation and the steps involved to ensure accurate and reliable results.

How is the Quadruple Marker Test Done?

The Quadruple Marker Test is a blood test. A healthcare professional will collect a sample of blood from a vein in your arm, usually taking just a few minutes. The process is simple and typically does not cause any discomfort. Once the analysis is complete, your healthcare provider will review the results, taking into account your medical history, age, and other factors, and discuss any necessary next steps if any markers are outside the normal range.

Is Fasting Required for the Quadruple Marker Test?

No, fasting is not required for the Quadruple Marker Test. You can eat and drink as usual before the test, as it is a simple blood test that does not depend on fasting for accurate results. However, it's always a good idea to follow any specific instructions provided by your healthcare provider. 

What Time of the Day Should I Undergo a Quadruple Marker Test?

The Quadruple Marker Test can be taken at any time of the day that suits you, as the time of testing does not impact the results. However, it is crucial to undergo the test within the recommended window of 15 to 20 weeks of pregnancy, as this ensures the most reliable and meaningful risk assessment for the developing baby. 

Booking a Quadruple Marker Test Online & Checking Reports

This section provides a simple and clear guide for booking a Quadruple Marker Test online at Apollo 24|7 and how to access your test results.

What are the Steps to Schedule a Quadruple Marker Test on Apollo 24|7?

Booking a Quadruple Marker Test through Apollo 24|7 is convenient and can be done from the comfort of your home. Follow these easy steps:

1. Visit Apollo 24|7 Website or App:

Start by visiting the official Apollo 24|7 website or download their easy-to-use mobile app from the App Store or Google Play. The platform is designed to be intuitive and user-friendly for hassle-free navigation.

2.Search for the Test:

On the homepage, locate the search bar, typically positioned at the top of the page. Type in “Quadruple Marker Test Near Me” or “Maternal Serum Screening” to find the specific test page related to the quadruple marker test, which screens for chromosomal abnormalities like Down syndrome, Trisomy 18, and neural tube defects.

3.Select a Convenient Time and Location:

Once you are on the Quadruple Marker Test page, choose a suitable time slot for the test and select your preferred location from the available collection centres or diagnostic facilities. You will also find information on the test cost on this page.

4.Complete Your Booking:

After choosing your time and location, fill in your details to complete the booking process. Ensure all the information provided is correct to avoid any issues during the test.

5.Wait for Confirmation:

After completing the booking, you will receive a confirmation message or email from Apollo 24|7 verifying your booking details. This confirms that your test request has been successfully processed.

How Do I Access My Quadruple Marker Test Results Online on Apollo 24|7?

Once your Quadruple Marker Test is completed, retrieving your results through Apollo 24|7 is simple and secure. Here's how you can access your results:

1.Await Notification:

After your Quadruple Marker Test is completed, Apollo 24|7 will notify you when your test results are ready for viewing.
2.Log in to Your Account:

Use your login credentials to access your Apollo 24|7 account through their website or mobile app. The secure login process ensures that your health data remains private.

3.Navigate to the Reports Section:

Once logged in, go to the 'Reports' section located in your account dashboard. This section contains all your medical test results, including your Quadruple Marker Test results.

4.Select Your Test Report:

Browse through the list of available test reports and locate the Quadruple Marker Test results you wish to view.

5.Download or View Report:

You will have the option to either view the report directly on the platform or download it for your records. Choose the appropriate option based on your preference.