MPL (Myeloproliferative Leukemia), Gene Mutation

The myeloproliferative (MPL) gene regulates the number of blood cells produced in the bone marrow. It provides instructions to the body for making thrombopoietin receptor protein, which helps the body promote cell growth and division.

A myeloproliferative gene disorder causes blood cells, such as red blood cells, white blood cells or platelets, to grow abnormally in the bone marrow. This may cause anaemia, infections, fatigue, bleeding problems, and other symptoms. Myeloproliferative gene disorder are not generally noticed until years after the onset because this disorder builds up slowly.

Specifications of MPL Gene Mutation Test

The MPL gene mutation test includes a complete blood count test that measures the levels of various cells such as red blood cells, white blood cells, and platelets in your blood. 

Since leukaemia often starts in the bone marrow, checking the bone marrow for leukaemia cells is one of the primary aspects of testing. Bone marrow samples are collected from two different tests that are conducted at the same time:

• Bone marrow aspiration
• Bone marrow biopsy
• The samples are then examined for abnormal cells.

People aged 45-50 are at higher risk of MPL gene mutation. High radiation doses may further increase the risk. Men fall higher on the risk graph for this disease. 

It is recommended to get yourself tested at the first signs of symptoms. If left untreated, it could be life-threatening. 

Who Should Get Tested? 

One of the initial signs of myeloproliferative gene disorder is an enlarged spleen. You will likely get tested for MPL leukaemia if you have an enlarged spleen. This condition requires immediate attention and care when diagnosed. People who often have shortness of breath, fatigue, loss of appetite, infections, and persistent bleeding from minor cuts also need to take the test.

Medically reviewed by Dr. Sanjaya Mishra, Radiation Oncology, Apollo Hospitals Old Sainik School Road, Bhubaneswar.