Multiple Myeloma - Karyotyping+Fish

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    blood sample




    Age group

    Above 10 years

    Fluorescence In-Situ Hybridization (FISH) test is used to map the genetic information present in the human cell. A FISH test is beneficial for diagnosing certain forms of cancer as it can detect chromosomal mutations linked with the disease. This includes multiple myeloma. It can also provide information to help estimate whether a patient is likely to respond to chemotherapy drugs.

    A FISH test employs fluorescent dyes that exclusively bind to certain regions of the chromosomes. The test can detect most chromosomal alterations, such as deletion or translocation. These are visible using a microscope in regular cytogenetic tests too. However, a FISH test can also spot changes that are too minor to detect using cytogenetic testing.

    Cancer cells exhibit the following abnormalities during a FISH test:

    • Deletion: A chromosomal segment is missing.
    • Duplication: A portion of a chromosome has duplicated, causing the cell to have excess copies.
    • Inversion: A chromosomal segment is in reverse order but is still linked to the right chromosome.
    • Translocation: A piece of one chromosome has split and moved to another chromosome.

    A karyotype test, on the other hand, examines the chromosomes using blood or bodily fluids. Adults may require a Karyotype genetic testing for the following reasons:

    • Experiencing infertility
    • Have cancer or blood diseases
    • Have certain genetic conditions in the family

    Unborn babies in the womb may also require karyotyping when their parents have a history of genetic abnormalities or if their mother is over 35.

    Apollo 24|7 offers a package combining Karyotyping with the FISH test for diagnosing multiple myeloma in adults. These tests can be used to determine appropriate treatments for anyone diagnosed with the disease.

    On receiving a diagnosis through the Karyotyping test and FISH test, a healthcare provider generally recommends one of the following treatments for multiple myeloma.

    • Chemotherapy: Chemotherapy employs the use of medications to destroy cancer cells.
    • Corticosteroids: Corticosteroid drugs manage systemic inflammation by regulating the immune system.
    • Drug therapy: Targeted drug therapy specifically targets defects in cancer cells.
    • Immunotherapy: Immunotherapy makes use of the immune system to combat cancer.
    • Radiation: Radiation therapy kills cancer cells by delivering high-energy beams from sources such as protons and X-rays.
    • Stem cell transplants: A stem cell transplant or a bone marrow transplant is a treatment that replaces unhealthy bone marrow with healthy bone marrow.

    Most of these treatments can be pretty effective in treating the symptoms of multiple myeloma, such as:

    • Appetite loss
    • Bone pain, particularly in the spine or chest
    • Constipation
    • Extreme thirst
    • Fatigue and nausea
    • Loss of weight
    • Mental fogginess
    • Recurring infections

    It is advisable to consult a healthcare provider as soon as one notices these symptoms. This can help the healthcare provider order a Karyotype and FISH test and quickly start appropriate treatment.

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    The FISH test maps the genetic information in human cells, such as specific genes or certain segments of genes. It is beneficial in identifying several forms of cancer, including multiple myeloma since it can detect genetic abnormalities linked with cancers.
    The most commonly used genetic testing for multiple myeloma is the FISH test.
    A FISH test typically yields one of the two outcomes: positive or negative. A positive result indicates that the cancer cells produce an excessive amount of HER2 protein. In this scenario, the doctor may prescribe medication that targets the specific protein. A negative result indicates that the protein is not involved in tumour development.
    Multiple myeloma is a form of cancer that develops in the plasma cells of the bone marrow. Plasma cells are cells of the immune system. They generally produce antibodies or immunoglobulins, which help fight against infections.
    The risk of multiple myeloma increases with age. However, men over the age of 60 are most likely to be diagnosed with it than women. Moreover, those with a family history of multiple myeloma are also at risk. Having a history of monoclonal gammopathy of undetermined significance (MGUS) raises the chances of being diagnosed with multiple myeloma.
    A variety of treatment options are available for individuals with multiple myeloma. Thus, individuals with this ailment can lead a reasonably normal life. Moreover, if cancer develops slowly, one may not require treatment immediately. Your doctor may simply advise close observation rather than medication.

    Why should Apollo be your preferred healthcare partner?

    • 40 Years of legacy and credibility in the healthcare industry.
    • NABL certified multi-channel digital healthcare platform.
    • Affordable diagnostic solutions with timely and accurate test results.
    • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
    • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results