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Myasthenia gravis (MG) is a condition indicated by muscular weakness and excessive fatigue in the voluntary muscles. It is caused by a disruption in the connection between the muscles and the nerves. Myasthenia gravis has no cure. However, treatment and adequate observation can help improve symptoms, such as:
Although this condition can affect people of every age, it is more prevalent in women under the age of 40 and males over the age of 60.
The majority of individuals with myasthenia gravis have acetylcholine receptor (AChR) antibodies. However, AChR antibodies are absent in about 15% of patients with myasthenia gravis. If no AChR antibodies are found, a medical provider can recommend a muscle-specific kinase (MuSK) antibody test.
The total number of people with myasthenia gravis who test negative for AChR antibodies but positive for MuSK antibodies range from 6%-50%.
Anti-muscle-specific kinase (Anti-MuSK) antibodies are autoantibodies generated by the body's immune response to attack its own muscle-specific kinase proteins. The MuSK antibody test evaluates the number of autoantibodies in myasthenia gravis patients.
This test is conducted to differentiate myasthenia gravis from other illnesses with similar symptoms, such as regular muscle fatigue and weakness. A positive test result might indicate myasthenia gravis, which is treated with corticosteroids and immunosuppressants, as well as therapy and surgery in the case of malignancy or tumour.
Some of the other symptoms of myasthenia gravis that could prompt a healthcare provider to order a MuSK antibody test include:
During myasthenia gravis, the immune system creates antibodies that obstruct or kill many of the muscles' acetylcholine receptor sites. As a result, the muscles obtain fewer nerve impulses since there are fewer accessible receptor sites, resulting in fatigue. It is classified as an autoimmune disorder.
Even with a diagnosis using a MuSK antibody test, it is possible to live a regular life. Doctors frequently recommend that individuals with myasthenia gravis avoid all strenuous activity and anything that may demand significant physical exertion.
Autoimmune illnesses are not influenced by changes or variations in a particular gene. Therefore, they are not regarded as hereditary conditions. However, some people may be born with a genetic mutation that produces congenital myasthenic syndrome — a hereditary disorder with symptoms similar to myasthenia gravis but unrelated causes.
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The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results