Phenytoin Level - Dilantin in Bansdroni, Kolkata

Phenytoin Level (Dilantin): Price, Purpose, Range & Reports

Test Overview

The Phenytoin Level test measures the concentration of the anti-epileptic drug Phenytoin (commonly known by its brand name, Dilantin) in a patient's blood. This test is a standard component of Therapeutic Drug Monitoring (TDM), which is essential because Phenytoin has a narrow margin between effective dose and toxic dose. The goal of this test is to ensure the drug concentration is high enough to prevent seizures but low enough to avoid serious side effects.

If you are looking for the Phenytoin Level price or need to schedule this blood test, you can search for the service through Apollo 24|7 to find accredited lab testing options near you.

What is the Phenytoin Level Test?

The Phenytoin Level Test is a blood test used to measure the exact amount of phenytoin circulating in the body. Phenytoin is a medication prescribed to prevent and control seizures, especially in people with epilepsy. Because it is metabolised by the liver, its elimination rate can vary widely between individuals due to genetics, liver function, other medications, and overall health.

Unlike many drugs, phenytoin does not follow a predictable dose-to-level relationship. Small changes in dosage can lead to large shifts in blood concentration, making therapeutic drug monitoring (TDM) essential. This test helps doctors ensure that phenytoin levels stay within a safe and effective range, minimising the risk of uncontrolled seizures or drug toxicity. It is commonly ordered when starting treatment, adjusting the dose, or checking for side effects.

What is the Phenytoin Level Price?

The cost of the Phenytoin Level (TDM) test is determined by the specialised laboratory methods (often Immunoassay or HPLC) required to accurately measure small drug concentrations in the blood. Factors influencing the price include:

• Test Type: Whether the lab measures the Total Phenytoin level (most common) or the less common Free Phenytoin level (unbound, active drug).
• Lab Technology: The use of sophisticated analytical equipment and reagents.
• Location: Prices may vary slightly across different regions based on local operating costs.
• Accreditation: Pricing at NABL-accredited labs, like those associated with Apollo, reflects high standards of quality control and precision.

If you're trying to find the most accurate and affordable Phenytoin Level Test price near you, the easiest way is to check the Apollo 24|7 website or app. They update prices regularly based on your location, so you’ll always see the latest rates and any available offers.

What is the Purpose of the Phenytoin Level Test?

The Phenytoin Level test serves several critical purposes in patient management:

1. Establish Optimal Dosage: To find the individualised dose that keeps the patient within the therapeutic window when initiating treatment.
2. Ensure Efficacy: To confirm that the blood level is sufficient (greater than 10 micrograms per millilitre or 10 mcg/mL) to prevent seizures (sub-therapeutic levels can lead to breakthrough seizures).
3. Prevent Toxicity: To ensure the level is not excessively high (greater than 20 micrograms per millilitre or 20 mcg/mL), which can cause serious central nervous system side effects.
4. Investigate Symptoms: To determine if new symptoms like lethargy, nausea, nystagmus (involuntary eye movement), or ataxia (lack of muscle coordination) are due to drug toxicity.
5. Monitor Compliance & Interactions: To check if the patient is taking the medication as prescribed or if other medications are affecting Phenytoin's metabolism (e.g., enzyme-inducing or inhibiting drugs).

Who Should Get the Phenytoin Level Test?

The Phenytoin Level Test is recommended for individuals who are taking phenytoin to manage seizures or epilepsy. Because phenytoin has a narrow therapeutic range and its blood levels can be affected by many factors, regular monitoring is essential to ensure the drug is both safe and effective.

You may be advised to get this test if:

• You have recently started phenytoin therapy: The test helps establish whether the initial dose is achieving therapeutic levels.
• Your dose has been adjusted: Small changes in dosage can lead to large shifts in blood concentration due to phenytoin’s non-linear metabolism.
• You continue to have seizures despite treatment: Measuring drug levels can help determine if underdosing is contributing to poor seizure control.
• You show signs of toxicity: Symptoms such as dizziness, confusion, slurred speech, or unsteady gait may indicate excessive phenytoin levels.
• You are taking other medications: Phenytoin interacts with many drugs that can alter its concentration in the blood.
• You have liver disease or low albumin levels: These conditions affect how phenytoin binds in the blood, making a free phenytoin level test more appropriate.
• You are pregnant or have other physiological changes: These can alter drug metabolism and require closer monitoring.

This test helps your doctor fine-tune your treatment, prevent side effects, and ensure optimal seizure control.

Components of the Phenytoin Level Test

The test measures the concentration of Phenytoin itself in the blood. Phenytoin exists in two forms in the blood:

• Bound Phenytoin: The majority of the drug (around 90 %) is bound to plasma proteins, primarily albumin. This portion is inactive and cannot cross the blood-brain barrier.
• Free (Unbound) Phenytoin: The remaining 10 % is unbound. This is the biologically active component that enters the brain to exert its anti-seizure effect.

The two main testing options are:

• Total Phenytoin Level: Measures the combined concentration of both bound and free drug. This is the most commonly requested test.
• Free Phenytoin Level: Measures only the active, unbound drug. This is typically requested when protein levels (like albumin) are abnormal, such as in cases of liver disease, kidney failure, or malnutrition, as the total level may be misleading.

Understanding the Phenytoin Level Test Report: Interpretation

Phenytoin concentrations are typically reported in micrograms per millilitre (mcg/mL) or milligrams per litre (mg/L).

Key Interpretation Points

Note: Dosage adjustments must be made carefully by a physician, as Phenytoin exhibits non-linear (zero-order) pharmacokinetics, meaning small dose increases can lead to disproportionately large increases in blood concentration.

Preparation and Procedure for the Phenytoin Level Test

1. Timing is Critical (Trough Level)

For the most accurate assessment of the lowest drug concentration (known as the trough level), the blood sample MUST be collected:

• Just before the next scheduled dose.
• It is vital to communicate the exact dose timing to the phlebotomist and the laboratory. Drawing the sample too soon after a dose will result in a misleadingly high level.

2. How is the Test Done?

The procedure is simple:

• A standard venous blood sample is drawn, typically from a vein in the arm.
• The blood is processed to separate the serum or plasma, which is then analysed using specialised equipment to quantify the drug concentration.

3. Is Fasting Required for This Test?

Fasting is generally NOT required for the Phenytoin Level test, provided the timing is correct (trough level). You can take your regular meals and non-dosed medications. However, always follow the specific instructions given by your doctor or the lab when scheduling the collection.

4. Should I Inform My Doctor About Other Medications I Am Taking?

Yes, absolutely. It is crucial to provide your doctor and the lab with a complete list of all prescription medications, over-the-counter drugs, supplements, and herbal products you are currently taking. Phenytoin interacts with a large number of common drugs (including antibiotics, antifungals, other anti-epileptic drugs, and even antacids) that can either drastically increase or decrease the Phenytoin concentration in your blood. This information is vital for correctly interpreting your test results and ensuring your dose is safe and effective.

Booking Phenytoin Level Test Online & Checking Reports

Apollo 24|7 makes it easy to book your test and access your results quickly.

A. What are the Steps to Schedule the Test on Apollo 24|7?

1. Visit the Apollo 24|7 platform and search for Phenytoin Level - Dilantin.
2. Review the latest Phenytoin Level price for your location and click 'Book Now'.
3. Select a convenient date and time for sample collection. (Remember to coordinate the timing with your dosing schedule.)
4. Complete the secure online payment to confirm your booking.

B. How Do I Access My Test Results Online on Apollo 24|7?

1. Log in to your Apollo 24|7 account via the website or mobile app.
2. Navigate to the 'Health Records' or 'My Reports' section.
3. Click on the completed Phenytoin Level report.
4. You can view and download the detailed report in PDF format, which you should share promptly with your prescribing physician.

Conclusion

The Phenytoin Level test is essential for personalised medicine, transforming the art of prescribing into a precise science. Regular monitoring ensures you benefit from optimal seizure control while minimising the risk of serious side effects. Be sure to discuss the timing of your dose relative to the blood draw with your healthcare provider.